Ruben D. Carrasco, MD, PhD

Publications

• Anderson KC, Carrasco RD.Pathogenesis of myeloma.Annu Rev Pathol. 2011 Feb 28;6:249-74.
  21261519
• Gatt ME, Zhao JJ, Ebert MS, Zhang Y, Chu Z, Mani M, Gazit R, Carrasco DE, Dutta-Simmons J, Adamia S, Minvielle S, Tai YT, Munshi NC, Avet-Loiseau H, Anderson KC, Carrasco DR.MicroRNAs 15a/16-1 function as tumor suppressor genes in multiple myeloma.Blood.
  20962322
• Peña-Cruz V, McDonough SM, Diaz-Griffero F, Crum CP, Carrasco RD, Freeman GJ.PD-1 on Immature and PD-1 Ligands on Migratory Human Langerhans Cells Regulate Antigen-Presenting Cell Activity.J Invest Dermatol. 2010 Sep;130(9):2222-30.
  20445553
• Görgün G, Calabrese E, Hideshima T, Ecsedy J, Perrone G, Mani M, Ikeda H, Bianchi G, Hu Y, Cirstea D, Santo L, Tai YT, Nahar S, Zheng M, Bandi M, Carrasco RD, Raje N, Munshi N, Richardson P, Anderson KC.A novel Aurora-A kinase inhibitor MLN8237 induces
  20382844
• Hideshima T, Mitsiades C, Ikeda H, Chauhan D, Raje N, Gorgun G, Hideshima H, Munshi NC, Richardson PG, Carrasco DR, Anderson KC.A proto-oncogene Bcl-6 is upregulated in the bone marrow microenvironment in multiple myeloma cells.Blood. 2010 May 6;115(18):3
  20228272
• Chauhan D, Singh AV, Brahmandam M, Carrasco R, Bandi M, Hideshima T, Bianchi G, Podar K, Tai YT, Mitsiades C, Raje N, Jaye DL, Kumar SK, Richardson P, Munshi N, Anderson KC.Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells
  19800576
• Mani M, Carrasco DE, Zhang Y, Takada K, Gatt ME, Dutta-Simmons J, Ikeda H, Diaz-Griffero F, Pena-Cruz V, Bertagnolli M, Myeroff LL, Markowitz SD, Anderson KC, Carrasco DR.BCL9 promotes tumor progression by conferring enhanced proliferative, metastatic, an
  19738061
• Dutta-Simmons J, Zhang Y, Gorgun G, Gatt M, Mani M, Hideshima T, Takada K, Carlson NE, Carrasco DE, Tai YT, Raje N, Letai AG, Anderson KC, Carrasco DR.Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression.Blood.
  19652203
• Chauhan D, Singh AV, Brahmandam M, Carrasco R, Bandi M, Podar K, Hideshima T, Bianchi G, Mitsiades C, Raje N, Tai Y-T, Jaye DL, Kumar SK, Schlossman R, Richardson P, Munshi N, Anderson KC.Functional Interaction of plasmacytoid dendritic cells with multipl
• Hideshima T,Ikeda H,Chauhan D,Okawa Y,Raje N,Podar K,Mitsiades C,Munshi NC,Richardson PG,Carrasco RD,Anderson KC.Bortezomib induces canonical NF-{kappa}B activation in multiple myeloma cells.Blood. 2009 Jul 30;114(5):1046-52.
  19436050
• Hideshima T,Chauhan D,Kiziltepe T,Ikeda H,Okawa Y,Podar K,Raje N,Protopopov A,Munshi NC,Richardson PG,Carrasco RD,Anderson KC.Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications.Blood. 2009 May 21;113(21):5
  19270264
• Leleu X,Hunter ZR,Xu L,Roccaro AM,Moreau AS,Santos DD,Hatjiharissi E,Bakthavachalam V,Adamia S,Ho AW,Soumerai J,Patterson CJ,Manning RJ,Hamilton S,Verselis S,Fox E,Carrasco R,Ghobrial IM,Treon SP.Expression of regulatory genes for lymphoplasmacytic cell d
  19220283
• Tai YT,Soydan E,Song W,Fulciniti M,Kim K,Hong F,Li XF,Burger P,Rumizen MJ,Nahar S,Podar K,Hideshima T,Munshi NC,Tonon G,Carrasco RD,Afar DE,Anderson KC.CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated i
  19196658
• Jinushi M,Nakazaki Y,Carrasco DR,Draganov D,Souders N,Johnson M,Mihm MC,Dranoff G.Milk fat globule EGF-8 promotes melanoma progression through coordinated Akt and twist signaling in the tumor microenvironment.Cancer Res. 2008 Nov 1;68(21):8889-98.
  18974133
• Jinushi M, Vanneman M, Munshi NC, Tai YT, Prabhala RH, Ritz J, Neuberg D, Anderson KC, Carrasco DR, Dranoff G.MHC class I chain-related protein A antibodies and shedding are associated with the progression of multiple myeloma.Proc Natl Acad Sci U S A. 200
  18202175
• Leleu X, Jia X, Runnels J, Ngo HT, Moreau AS, Farag M, Spencer JA, Pitsillides CM, Hatjiharissi E, Roccaro A, O'Sullivan G, McMillin DW, Moreno D, Kiziltepe T, Carrasco R, Treon SP, Hideshima T, Anderson KC, Lin CP, Ghobrial IM.The Akt pathway regulat
  17761832
• Jinushi M, Nakazaki Y, Dougan M, Carrasco DR, Mihm M, Dranoff G.MFG-E8-mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF.J Clin Invest. 2007 Jul;117(7):1902-13.
  17557120
• Ramsey MR, Krishnamurthy J, Pei XH, Torrice C, Lin W, Carrasco DR, Ligon KL, Xiong Y, Sharpless NE.Expression of p16Ink4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6-dependent tumors and tissues.Cancer Res. 2007 May 15;67(10):4732-41.
  17510401
• Sukhdeo K, Mani M, Zhang Y, Dutta J, Yasui H, Rooney MD, Carrasco DE, Zheng M, He H, Tai YT, Mitsiades C, Anderson KC, Carrasco DR.Targeting the beta-catenin/TCF transcriptional complex in the treatment of multiple myeloma.Proc Natl Acad Sci U S A. 2007 M
  17452641
• Carrasco DR, Sukhdeo K, Protopopova M, Sinha R, Enos M, Carrasco DE, Zheng M, Mani M, Henderson J, Pinkus GS, Munshi N, Horner J, Ivanova EV, Protopopov A, Anderson KC, Tonon G, DePinho RA.The differentiation and stress response factor XBP-1 drives multip
  17418411
• Khoo CM, Carrasco DR, Bosenberg MW, Paik JH, Depinho RA.Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse.Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3931-6.
  17360455
• Yasui H, Hideshima T, Ikeda H, Ocio EM, Kiziltepe T, Vallet S, Okawa Y, Neri P, Sukhdeo K, Podar K, Chauhan D, Richardson PG, Raje N, Carrasco DR, Anderson KC.Novel etodolac analog SDX-308 (CEP-18082) induces cytotoxicity in multiple myeloma cells associa
  17268521
• Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, Miao L, Tothova Z, Horner JW, Carrasco DR, Jiang S, Gilliland DG, Chin L, Wong WH, Castrillon DH, DePinho RA.FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeosta
  17254969
• Carrasco DR, Fenton T, Sukhdeo K, Protopopova M, Enos M, You MJ, Divicio D, Nogueira C, Stommel J, Pinkus GS, Fletcher C, Hornick JL, Cavenee WK, Furnari FB, Depinho RA.The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooper
  16697958
• Carrasco DR, Tonon G, Huang Y, Zhang Y, Sinha R, Feng B, Stewart JP, Zhan F, Khatry D, Protopopova M, Protopopov A, Sukhdeo K, Hanamura I, Stephens O, Barlogie B, Anderson KC, Chin L, Shaughnessy JD, Brennan C, Depinho RA.High-resolution genomic profiles
  16616336
• Tang Y, Kim M, Carrasco D, Kung AL, Chin L, Weissleder R.In vivo assessment of RAS-dependent maintenance of tumor angiogenesis by real-time magnetic resonance imaging.Cancer Res. 2005 Sep 15;65(18):8324-30.
  16166309
• Tassone P, Neri P, Carrasco DR, Burger R, Goldmacher VS, Fram R, Munshi V, Catley L, Jacob GS, Venuta S, Anderson KC, Munshi NC.A clinically relevant SCID-hu in vivo model of human multiple myeloma.Blood. 2005 Jul 15;106(2):713-6.
  15817674
• Tassone P, Goldmacher VS, Neri P, Gozzini A, Shammas MA, Whiteman KR, Hylander-Gans LL, Carrasco DR, Hideshima T, Shringarpure R, Shi J, Allam CK, Wijdenes J, Venuta S, Munshi NC, Anderson KC.Cytotoxic activity of the maytansinoid immunoconjugate B-B4-DM1
  15292058
• Tassone P, Gozzini A, Goldmacher V, Shammas MA, Whiteman KR, Carrasco DR, Li C, Allam CK, Venuta S, Anderson KC, Munshi NC.In vitro and in vivo activity of the maytansinoid immunoconjugate huN901-N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansin
  15231675
• Munshi NC, Hideshima T, Carrasco D, Shammas M, Auclair D, Davies F, Mitsiades N, Mitsiades C, Kim RS, Li C, Rajkumar SV, Fonseca R, Bergsagel L, Chauhan D, Anderson KC.Identification of genes modulated in multiple myeloma using genetically identical twin
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• Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, DePinho RA.Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.Nature. 2003 Feb 6;421(6923):643-8.
  12540856
• Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE, Loda M, Carrasco DR, DePinho RA.Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation.Nature. 2002 Sep 12;419(6903):162-7.
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• Sharpless NE, Bardeesy N, Lee KH, Carrasco D, Castrillon DH, Aguirre AJ, Wu EA, Horner JW, DePinho RA.Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis.Nature. 2001 Sep 6;413(6851):86-91.
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• Yang Y, Loy J, Ryseck RP, Carrasco D, Bravo R.Antigen-induced eosinophilic lung inflammation develops in mice deficient in chemokine eotaxin.Blood. 1998 Nov 15;92(10):3912-23.
  9808585
• Carrasco D, Cheng J, Lewin A, Warr G, Yang H, Rizzo C, Rosas F, Snapper C, Bravo R.Multiple hemopoietic defects and lymphoid hyperplasia in mice lacking the transcriptional activation domain of the c-Rel protein.J Exp Med. 1998 Apr 6;187(7):973-84.
  9529314
• Zelazowski P, Carrasco D, Rosas FR, Moorman MA, Bravo R, Snapper CM.B cells genetically deficient in the c-Rel transactivation domain have selective defects in germline CH transcription and Ig class switching.J Immunol. 1997 Oct 1;159(7):3133-9.
  9317110
• Ishikawa H, Carrasco D, Claudio E, Ryseck RP, Bravo R.Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2.J Exp Med. 1997 Oct 6;186(7):999-1014.
  9314550
• Carrasco D, Perez P, Lewin A, Bravo R.IkappaBalpha overexpression delays tumor formation in v-rel transgenic mice.J Exp Med. 1997 Jul 21;186(2):279-88.
  9221757
• Attar RM, Caamaño J, Carrasco D, Iotsova V, Ishikawa H, Ryseck RP, Weih F, Bravo R.Genetic approaches to study Rel/NF-kappa B/I kappa B function in mice.Semin Cancer Biol. 1997 Apr;8(2):93-101.
  9299587
• Dorfman K, Carrasco D, Gruda M, Ryan C, Lira SA, Bravo R.Disruption of the erp/mkp-1 gene does not affect mouse development: normal MAP kinase activity in ERP/MKP-1-deficient fibroblasts.Oncogene. 1996 Sep 5;13(5):925-31.
  8806681
• Carrasco D, Rizzo CA, Dorfman K, Bravo R.The v-rel oncogene promotes malignant T-cell leukemia/lymphoma in transgenic mice.EMBO J. 1996 Jul 15;15(14):3640-50.
  8670867
• Ryseck RP, Weih F, Carrasco D, Bravo R.RelB, a member of the Rel/NF-kappa B family of transcription factors.Braz J Med Biol Res. 1996 Jul;29(7):895-903.
  9070378
• Carrasco D, Bravo R.Tissue-specific expression of the fos-related transcription factor fra-2 during mouse development.Oncogene. 1995 Mar 16;10(6):1069-79.
  7700631
• Weih F, Carrasco D, Durham SK, Barton DS, Rizzo CA, Ryseck RP, Lira SA, Bravo R.Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family.Cell. 1995 Jan 27;80(2):331-40.
  7834753
• Lira SA, Zalamea P, Heinrich JN, Fuentes ME, Carrasco D, Lewin AC, Barton DS, Durham S, Bravo R.Expression of the chemokine N51/KC in the thymus and epidermis of transgenic mice results in marked infiltration of a single class of inflammatory cells.J Exp
  7964481
• Weih F, Carrasco D, Bravo R.Constitutive and inducible Rel/NF-kappa B activities in mouse thymus and spleen.Oncogene. 1994 Nov;9(11):3289-97.
  7936653
• Carrasco D, Weih F, Bravo R.Developmental expression of the mouse c-rel proto-oncogene in hematopoietic organs.Development. 1994 Oct;120(10):2991-3004.
  7607087
• Carrasco D, Bravo R.Expression of the nontransmembrane tyrosine phosphatase gene erp during mouse organogenesis.Cell Growth Differ. 1993 Oct;4(10):849-59.
  8274454
• Noguchi T, Metz R, Chen L, Mattéi MG, Carrasco D, Bravo R.Structure, mapping, and expression of erp, a growth factor-inducible gene encoding a nontransmembrane protein tyrosine phosphatase, and effect of ERP on cell growth.Mol Cell Biol. 1993 Sep;13(9):51
  8355678
• Carrasco D, Ryseck RP, Bravo R.Expression of relB transcripts during lymphoid organ development: specific expression in dendritic antigen-presenting cells.Development. 1993 Aug;118(4):1221-31.
  8269849
• Bustelo XR, Rubin SD, Suen KL, Carrasco D, Barbacid M.Developmental expression of the vav protooncogene.Cell Growth Differ. 1993 Apr;4(4):297-308.
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