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Ruben D. Carrasco, MD, PhD

Publications

  • Cottini F, Hideshima T, Xu C, Sattler M, Dori M, Agnelli L, Ten Hacken E, Bertilaccio MT, Antonini E, Neri A, Ponzoni M, Marcatti M, Richardson PG, Carrasco R, Kimmelman AC, Wong KK, Caligaris-Cappio F, Blandino G, Kuehl WM, Anderson KC, Tonon G.Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers.Nat Med. 2014 Jun;20(6):599-606.
    24813251
  • Zhou Y, Liu X, Xu L, Hunter ZR, Cao Y, Yang G, Carrasco R, Treon SP.Transcriptional repression of plasma cell differentiation is orchestrated by aberrant over-expression of the ETS factor SPIB in Waldenström macroglobulinaemia.British Journal of Haematology. 2014 May 7.
    24801987
  • Zhao JJ, Lin J, Zhu D, Wang X, Brooks D, Chen M, Chu ZB, Takada K, Ciccarelli B, Admin S, Tao J, Tai YT, Treon S, Pinkus G, Kuo WP, Hideshima T, Bouxsein M, Munshi N, Anderson K, Carrasco R.miR-30-5p functions as a tumor suppressor and novel therapeutic tool by targeting the oncogenic Wnt/β-catenin/BCL9 pathway.Cancer Res. 2014 Mar 15;74(6):1801-13.
    24599134
  • Tian Z, D'Arcy P, Wang X, Ray A, Tai YT, Hu Y, Carrasco RD, Richardson P, Linder S, Chauhan D, Anderson KC.A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance.Blood. 2014 Jan 30;123(5):706-16.
    24319254
  • Liu Y, Quang P, Braggio E, Ngo H, Badalian-Very G, Flores L, Zhang Y, Sacco A, Maiso P, Azab AK, Azab F, Carrasco R, Rollins BJ, Roccaro AM, Ghobrial IM.Novel tumor suppressor function of glucocorticoid-induced TNF receptor GITR in multiple myeloma.PLoS ONE. 2013;8(6):e66982.
    23785514
  • Gatt ME, Takada K, Mani M, Lerner M, Pick M, Hideshima T, Carrasco DE, Protopopov A, Ivanova E, Sangfelt O, Grandér D, Barlogie B, Shaughnessy JD, Anderson KC, Carrasco DR.TRIM13 (RFP2) downregulation decreases tumour cell growth in multiple myeloma through inhibition of NF Kappa B pathway and proteasome activity.British Journal of Haematology. 2013 May 7.
    23647456
  • Vo TT, Ryan J, Carrasco R, Neuberg D, Rossi DJ, Stone RM, Deangelo DJ, Frattini MG, Letai A.Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML.Cell. 2012 Oct 12;151(2):344-55.
    23063124
  • Chauhan D, Tian Z, Nicholson B, Kumar KG, Zhou B, Carrasco R, McDermott JL, Leach CA, Fulcinniti M, Kodrasov MP, Weinstock J, Kingsbury WD, Hideshima T, Shah PK, Minvielle S, Altun M, Kessler BM, Orlowski R, Richardson P, Munshi N, Anderson KC.A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.Cancer Cell. 2012 Sep 11;22(3):345-58.
    22975377
  • Fabre C, Mimura N, Bobb K, Kong SY, Gorgun G, Cirstea D, Hu Y, Minami J, Ohguchi H, Zhang J, Meshulam J, Carrasco RD, Tai YT, Richardson PG, Hideshima T, Anderson KC.Dual inhibition of canonical and noncanonical NF-κB pathways demonstrates significant antitumor activities in multiple myeloma.Clin Cancer Res. 2012 Sep 1;18(17):4669-81.
    22806876
  • Tai YT, Chang BY, Kong SY, Fulciniti M, Yang G, Calle Y, Hu Y, Lin J, Zhao JJ, Cagnetta A, Cea M, Sellitto MA, Zhong MY, Wang Q, Acharya C, Carrasco DR, Buggy JJ, Elias L, Treon SP, Matsui W, Richardson P, Munshi NC, Anderson KC.Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma.Blood. 2012 Aug 30;120(9):1877-87.
    22689860
  • Takada K, Zhu D, Bird GH, Sukhdeo K, Zhao JJ, Mani M, Lemieux M, Carrasco DE, Ryan J, Horst D, Fulciniti M, Munshi NC, Xu W, Kung AL, Shivdasani RA, Walensky LD, Carrasco DR.Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling.Sci Transl Med. 2012 Aug 22;4(148):148ra117.
    22914623
  • Anderson KC, Carrasco RD.Pathogenesis of myeloma.Annu Rev Pathol. 2011 Feb 28;6:249-74.
    21261519
  • Gatt ME, Zhao JJ, Ebert MS, Zhang Y, Chu Z, Mani M, Gazit R, Carrasco DE, Dutta-Simmons J, Adamia S, Minvielle S, Tai YT, Munshi NC, Avet-Loiseau H, Anderson KC, Carrasco DR.MicroRNAs 15a/16-1 function as tumor suppressor genes in multiple myeloma.Blood. 2010 Oct 20.
    20962322
  • Peña-Cruz V, McDonough SM, Diaz-Griffero F, Crum CP, Carrasco RD, Freeman GJ.PD-1 on Immature and PD-1 Ligands on Migratory Human Langerhans Cells Regulate Antigen-Presenting Cell Activity.J Invest Dermatol. 2010 Sep;130(9):2222-30.
    20445553
  • Görgün G, Calabrese E, Hideshima T, Ecsedy J, Perrone G, Mani M, Ikeda H, Bianchi G, Hu Y, Cirstea D, Santo L, Tai YT, Nahar S, Zheng M, Bandi M, Carrasco RD, Raje N, Munshi N, Richardson P, Anderson KC.A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma.Blood. 2010 Jun 24;115(25):5202-13.
    20382844
  • Hideshima T, Mitsiades C, Ikeda H, Chauhan D, Raje N, Gorgun G, Hideshima H, Munshi NC, Richardson PG, Carrasco DR, Anderson KC.A proto-oncogene Bcl-6 is upregulated in the bone marrow microenvironment in multiple myeloma cells.Blood. 2010 May 6;115(18):3772-5.
    20228272
  • Chauhan D, Singh AV, Brahmandam M, Carrasco R, Bandi M, Hideshima T, Bianchi G, Podar K, Tai YT, Mitsiades C, Raje N, Jaye DL, Kumar SK, Richardson P, Munshi N, Anderson KC.Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target.Cancer Cell. 2009 Oct 6;16(4):309-23.
    19800576
  • Mani M, Carrasco DE, Zhang Y, Takada K, Gatt ME, Dutta-Simmons J, Ikeda H, Diaz-Griffero F, Pena-Cruz V, Bertagnolli M, Myeroff LL, Markowitz SD, Anderson KC, Carrasco DR.BCL9 promotes tumor progression by conferring enhanced proliferative, metastatic, and angiogenic properties to cancer cells.Cancer Res. 2009 Oct 1;69(19):7577-86.
    19738061
  • Dutta-Simmons J, Zhang Y, Gorgun G, Gatt M, Mani M, Hideshima T, Takada K, Carlson NE, Carrasco DE, Tai YT, Raje N, Letai AG, Anderson KC, Carrasco DR.Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression.Blood. 2009 Sep 24;114(13):2699-708.
    19652203
  • Chauhan D, Singh AV, Brahmandam M, Carrasco R, Bandi M, Podar K, Hideshima T, Bianchi G, Mitsiades C, Raje N, Tai Y-T, Jaye DL, Kumar SK, Schlossman R, Richardson P, Munshi N, Anderson KC.Functional Interaction of plasmacytoid dendritic cells with multiple myeloma cells: a novel therapeutic target.Cancer Cell..
  • Hideshima T,Ikeda H,Chauhan D,Okawa Y,Raje N,Podar K,Mitsiades C,Munshi NC,Richardson PG,Carrasco RD,Anderson KC.Bortezomib induces canonical NF-{kappa}B activation in multiple myeloma cells.Blood. 2009 Jul 30;114(5):1046-52.
    19436050
  • Hideshima T,Chauhan D,Kiziltepe T,Ikeda H,Okawa Y,Podar K,Raje N,Protopopov A,Munshi NC,Richardson PG,Carrasco RD,Anderson KC.Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications.Blood. 2009 May 21;113(21):5228-36.
    19270264
  • Leleu X,Hunter ZR,Xu L,Roccaro AM,Moreau AS,Santos DD,Hatjiharissi E,Bakthavachalam V,Adamia S,Ho AW,Soumerai J,Patterson CJ,Manning RJ,Hamilton S,Verselis S,Fox E,Carrasco R,Ghobrial IM,Treon SP.Expression of regulatory genes for lymphoplasmacytic cell differentiation in Waldenstrom Macroglobulinemia.British Journal of Haematology. 2009 Apr;145(1):59-63.
    19220283
  • Tai YT,Soydan E,Song W,Fulciniti M,Kim K,Hong F,Li XF,Burger P,Rumizen MJ,Nahar S,Podar K,Hideshima T,Munshi NC,Tonon G,Carrasco RD,Afar DE,Anderson KC.CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cells.Blood. 2009 Apr 30;113(18):4309-18.
    19196658
  • Jinushi M,Nakazaki Y,Carrasco DR,Draganov D,Souders N,Johnson M,Mihm MC,Dranoff G.Milk fat globule EGF-8 promotes melanoma progression through coordinated Akt and twist signaling in the tumor microenvironment.Cancer Res. 2008 Nov 1;68(21):8889-98.
    18974133
  • Jinushi M, Vanneman M, Munshi NC, Tai YT, Prabhala RH, Ritz J, Neuberg D, Anderson KC, Carrasco DR, Dranoff G.MHC class I chain-related protein A antibodies and shedding are associated with the progression of multiple myeloma.Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1285-90.
    18202175
  • Leleu X, Jia X, Runnels J, Ngo HT, Moreau AS, Farag M, Spencer JA, Pitsillides CM, Hatjiharissi E, Roccaro A, O'Sullivan G, McMillin DW, Moreno D, Kiziltepe T, Carrasco R, Treon SP, Hideshima T, Anderson KC, Lin CP, Ghobrial IM.The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia.Blood. 2007 Dec 15;110(13):4417-26.
    17761832
  • Jinushi M, Nakazaki Y, Dougan M, Carrasco DR, Mihm M, Dranoff G.MFG-E8-mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF.J Clin Invest. 2007 Jul;117(7):1902-13.
    17557120
  • Ramsey MR, Krishnamurthy J, Pei XH, Torrice C, Lin W, Carrasco DR, Ligon KL, Xiong Y, Sharpless NE.Expression of p16Ink4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6-dependent tumors and tissues.Cancer Res. 2007 May 15;67(10):4732-41.
    17510401
  • Sukhdeo K, Mani M, Zhang Y, Dutta J, Yasui H, Rooney MD, Carrasco DE, Zheng M, He H, Tai YT, Mitsiades C, Anderson KC, Carrasco DR.Targeting the beta-catenin/TCF transcriptional complex in the treatment of multiple myeloma.Proc Natl Acad Sci U S A. 2007 May 1;104(18):7516-21.
    17452641
  • Carrasco DR, Sukhdeo K, Protopopova M, Sinha R, Enos M, Carrasco DE, Zheng M, Mani M, Henderson J, Pinkus GS, Munshi N, Horner J, Ivanova EV, Protopopov A, Anderson KC, Tonon G, DePinho RA.The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis.Cancer Cell. 2007 Apr;11(4):349-60.
    17418411
  • Khoo CM, Carrasco DR, Bosenberg MW, Paik JH, Depinho RA.Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse.Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3931-6.
    17360455
  • Yasui H, Hideshima T, Ikeda H, Ocio EM, Kiziltepe T, Vallet S, Okawa Y, Neri P, Sukhdeo K, Podar K, Chauhan D, Richardson PG, Raje N, Carrasco DR, Anderson KC.Novel etodolac analog SDX-308 (CEP-18082) induces cytotoxicity in multiple myeloma cells associated with inhibition of beta-catenin/TCF pathway.Leukemia. 2007 Mar;21(3):535-40.
    17268521
  • Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, Miao L, Tothova Z, Horner JW, Carrasco DR, Jiang S, Gilliland DG, Chin L, Wong WH, Castrillon DH, DePinho RA.FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.Cell. 2007 Jan 26;128(2):309-23.
    17254969
  • Carrasco DR, Fenton T, Sukhdeo K, Protopopova M, Enos M, You MJ, Divicio D, Nogueira C, Stommel J, Pinkus GS, Fletcher C, Hornick JL, Cavenee WK, Furnari FB, Depinho RA.The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans.Cancer Cell. 2006 May;9(5):379-90.
    16697958
  • Carrasco DR, Tonon G, Huang Y, Zhang Y, Sinha R, Feng B, Stewart JP, Zhan F, Khatry D, Protopopova M, Protopopov A, Sukhdeo K, Hanamura I, Stephens O, Barlogie B, Anderson KC, Chin L, Shaughnessy JD, Brennan C, Depinho RA.High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients.Cancer Cell. 2006 Apr;9(4):313-25.
    16616336
  • Tang Y, Kim M, Carrasco D, Kung AL, Chin L, Weissleder R.In vivo assessment of RAS-dependent maintenance of tumor angiogenesis by real-time magnetic resonance imaging.Cancer Res. 2005 Sep 15;65(18):8324-30.
    16166309
  • Tassone P, Neri P, Carrasco DR, Burger R, Goldmacher VS, Fram R, Munshi V, Catley L, Jacob GS, Venuta S, Anderson KC, Munshi NC.A clinically relevant SCID-hu in vivo model of human multiple myeloma.Blood. 2005 Jul 15;106(2):713-6.
    15817674
  • Tassone P, Goldmacher VS, Neri P, Gozzini A, Shammas MA, Whiteman KR, Hylander-Gans LL, Carrasco DR, Hideshima T, Shringarpure R, Shi J, Allam CK, Wijdenes J, Venuta S, Munshi NC, Anderson KC.Cytotoxic activity of the maytansinoid immunoconjugate B-B4-DM1 against CD138+ multiple myeloma cells.Blood. 2004 Dec 1;104(12):3688-96.
    15292058
  • Tassone P, Gozzini A, Goldmacher V, Shammas MA, Whiteman KR, Carrasco DR, Li C, Allam CK, Venuta S, Anderson KC, Munshi NC.In vitro and in vivo activity of the maytansinoid immunoconjugate huN901-N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine against CD56+ multiple myeloma cells.Cancer Res. 2004 Jul 1;64(13):4629-36.
    15231675
  • Munshi NC, Hideshima T, Carrasco D, Shammas M, Auclair D, Davies F, Mitsiades N, Mitsiades C, Kim RS, Li C, Rajkumar SV, Fonseca R, Bergsagel L, Chauhan D, Anderson KC.Identification of genes modulated in multiple myeloma using genetically identical twin samples.Blood. 2004 Mar 1;103(5):1799-806.
    12969976
  • Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, DePinho RA.Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.Nature. 2003 Feb 6;421(6923):643-8.
    12540856
  • Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE, Loda M, Carrasco DR, DePinho RA.Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation.Nature. 2002 Sep 12;419(6903):162-7.
    12226664
  • Sharpless NE, Bardeesy N, Lee KH, Carrasco D, Castrillon DH, Aguirre AJ, Wu EA, Horner JW, DePinho RA.Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis.Nature. 2001 Sep 6;413(6851):86-91.
    11544531
  • Yang Y, Loy J, Ryseck RP, Carrasco D, Bravo R.Antigen-induced eosinophilic lung inflammation develops in mice deficient in chemokine eotaxin.Blood. 1998 Nov 15;92(10):3912-23.
    9808585
  • Carrasco D, Cheng J, Lewin A, Warr G, Yang H, Rizzo C, Rosas F, Snapper C, Bravo R.Multiple hemopoietic defects and lymphoid hyperplasia in mice lacking the transcriptional activation domain of the c-Rel protein.J Exp Med. 1998 Apr 6;187(7):973-84.
    9529314
  • Zelazowski P, Carrasco D, Rosas FR, Moorman MA, Bravo R, Snapper CM.B cells genetically deficient in the c-Rel transactivation domain have selective defects in germline CH transcription and Ig class switching.J Immunol. 1997 Oct 1;159(7):3133-9.
    9317110
  • Ishikawa H, Carrasco D, Claudio E, Ryseck RP, Bravo R.Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2.J Exp Med. 1997 Oct 6;186(7):999-1014.
    9314550
  • Carrasco D, Perez P, Lewin A, Bravo R.IkappaBalpha overexpression delays tumor formation in v-rel transgenic mice.J Exp Med. 1997 Jul 21;186(2):279-88.
    9221757
  • Attar RM, Caamao J, Carrasco D, Iotsova V, Ishikawa H, Ryseck RP, Weih F, Bravo R.Genetic approaches to study Rel/NF-kappa B/I kappa B function in mice.Semin Cancer Biol. 1997 Apr;8(2):93-101.
    9299587
  • Dorfman K, Carrasco D, Gruda M, Ryan C, Lira SA, Bravo R.Disruption of the erp/mkp-1 gene does not affect mouse development: normal MAP kinase activity in ERP/MKP-1-deficient fibroblasts.Oncogene. 1996 Sep 5;13(5):925-31.
    8806681
  • Carrasco D, Rizzo CA, Dorfman K, Bravo R.The v-rel oncogene promotes malignant T-cell leukemia/lymphoma in transgenic mice.EMBO J. 1996 Jul 15;15(14):3640-50.
    8670867
  • Ryseck RP, Weih F, Carrasco D, Bravo R.RelB, a member of the Rel/NF-kappa B family of transcription factors.Braz J Med Biol Res. 1996 Jul;29(7):895-903.
    9070378
  • Carrasco D, Bravo R.Tissue-specific expression of the fos-related transcription factor fra-2 during mouse development.Oncogene. 1995 Mar 16;10(6):1069-79.
    7700631
  • Weih F, Carrasco D, Durham SK, Barton DS, Rizzo CA, Ryseck RP, Lira SA, Bravo R.Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family.Cell. 1995 Jan 27;80(2):331-40.
    7834753
  • Lira SA, Zalamea P, Heinrich JN, Fuentes ME, Carrasco D, Lewin AC, Barton DS, Durham S, Bravo R.Expression of the chemokine N51/KC in the thymus and epidermis of transgenic mice results in marked infiltration of a single class of inflammatory cells.J Exp Med. 1994 Dec 1;180(6):2039-48.
    7964481
  • Weih F, Carrasco D, Bravo R.Constitutive and inducible Rel/NF-kappa B activities in mouse thymus and spleen.Oncogene. 1994 Nov;9(11):3289-97.
    7936653
  • Carrasco D, Weih F, Bravo R.Developmental expression of the mouse c-rel proto-oncogene in hematopoietic organs.Development. 1994 Oct;120(10):2991-3004.
    7607087
  • Carrasco D, Bravo R.Expression of the nontransmembrane tyrosine phosphatase gene erp during mouse organogenesis.Cell Growth Differ. 1993 Oct;4(10):849-59.
    8274454
  • Noguchi T, Metz R, Chen L, Matti MG, Carrasco D, Bravo R.Structure, mapping, and expression of erp, a growth factor-inducible gene encoding a nontransmembrane protein tyrosine phosphatase, and effect of ERP on cell growth.Mol Cell Biol. 1993 Sep;13(9):5195-205.
    8355678
  • Carrasco D, Ryseck RP, Bravo R.Expression of relB transcripts during lymphoid organ development: specific expression in dendritic antigen-presenting cells.Development. 1993 Aug;118(4):1221-31.
    8269849
  • Bustelo XR, Rubin SD, Suen KL, Carrasco D, Barbacid M.Developmental expression of the vav protooncogene.Cell Growth Differ. 1993 Apr;4(4):297-308.
    8494792