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Research Programs

Clinical-based Research

Gastrointestinal Malignancies

Collaborative Interactions


Development of a mouse model for pancreatic cancer

Nabeel Bardeesy, PhD and Andy Aguirre have developed a histologically and genetically accurate mouse model of pancreatic adenocarcinoma that harbors pancreas-specific lesions in the signature pancreatic cancer genes Kras and Ink4a/Arf (Genes and Development 2003). | more

Hedgehog in pancreatic cancer tumorigenesis.

Studies from the laboratory of Sarah Thayer, MD, PhD, demonstrated abnormal regulation of Hedgehog (Hh) pathway signaling in both pancreatic adenocarcinoma and PanIN (Nature, 2003). | more

Development/Cancer- Ramesh Shivdasani

Lepourcelet et al., Development. 2005 Jan;132(2):415-27.   Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF). | more