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Research Programs

Clinical-based Research

Gastrointestinal Malignancies

Specific Aims

Specific Aims

CCSG Specific Aims of the GI Program

  • Identify the full spectrum of genetic mutations driving colorectal and pancreatic tumorigenesis

  • Develop and utilize model systems to understand mechanisms by which specific mutations contribute to disease and to evaluate and monitor targeted therapeutic interventions

  • Determine whether polymorphic variation in genes defined above increase risk and identify at-risk populations and determine whether these polymorphisms are modified by environmental risk factors.

  • Undertake targeted therapeutic trials utilizing novel endpoint assessment and imaging based upon the pathogenesis and pathophysiology of colorectal and pancreatic cancer

  • Determine the effectiveness of screening and treatments for colorectal and pancreatic cancer by evaluating patient outcomes