Developmental Projects funded from 2003 – present

PI

Institution

Project Title

Year 1 (2003-04)

Iliopoulos, Othon

MGH

Functional Analysis of the BHD Tumor-Suppressor Protein

Libermann, Towia

Jones, Jon

BIDMC

Genetic Classification of Clear Cell RCC

Michaelson, Dror

MGH

The Role of Bone-Targeted Therapy with Zoledronic Acid in Metastatic RCC

Panka, David

Mier, James

BIDMC

Potential synergy between sorafenib and AKT inhibitors against RCC*

Year 2 (2004-05)

Haber, Dan

Rivera, Miguel

MGH

Identification of Novel Genes in Sporadic Wilms Tumor* #

Artavonis-Tsakonas, Spyros

MGH

A Genetic Model for Target identification in VHL-HIF Signaling

Signoretti, Sabina

Moch, Holger

BWH

Molecular Analysis of RCC Using Single Nucleotide Polymorphisms (SNP) Arrays#

Alper, Seth

BIDMC

Role of Carbonic Anhydrase IX in Proliferation and Metastasis of RCC

Dabora, Sandra

BWH

A Phase II Multi-Center Study of Rapamycin for Treating Kidney Angiomyolipomas

Olumi, Aria

BIDMC

Pro-apoptotic TRAIL-directed Therapies for the Treatment of Advanced RCC

Ross, Robert

Weissleder, Ralph

DFCI

MGH

Comparison of pathologic microvessel density and monocrystalline iron oxide nanoparticle-enhanced MRI in evaluationg tumor vascularity in pts undergoing Nx for RCC

Year 3 (2005-06)

Alsop, David

Rofsky, Neil

BIDMC

ASL MRI Blood Flow for Monitoring Response to Anti-angiogenic Therapy*

Avigan, David

Rosenblatt, Jacalyn

BIDMC

Phenotypic and Functional Characteristics of Human T cells Stimulated ex vivo with DC/tumor Fusion Cells and Expanded with CD3, CD28 Ab*

Libermann, Towia

Zerbini, Luiz

BIDMC

The Tyrosine Kinase Receptor Axl, a Novel Therapeutic Target in RCC^#

Seth, Pankaj

BIDMC

Role of Angiopoietin like 4 (ANGPTL4) as a VEGF Independent Pro-angiogenesis Factor

Year 4 (2006-07)

Marasco, Wayne

Wu, Anna

DFCI

UCLA

PET Evaluation of RCC Metastases using High-affinity Human Anti-CAIX Monoclonal Antibody with Optimized Pharmacokinetic Properties

Signoretti, Sabina

BWH

Development of Mouse Orthotopic Xenografts of Human RCC^{# *}

Frank, David

DFCI

STAT-Mediated Modulation of HIF Signaling: Molecular Strategies for the Treatment of RCC^#

Lenahan (Zarwan), Corine

Rosenblatt, Jacalyn

Avigan, David

BIDMC

The effect of Anti-angiogenic Drugs on Tumor Mediated Immune Suppression and Response to the DC/RCC Fusion Vaccine*

Iliopoulos, Othon

MGH

A Drosophila Genetic Screen for Target Identification in VHL-HIF Signaling

Goldberg, Nahum

Mier, James

BIDMC

Mechanism of RCC Resistance to VEGFR Blockade with Sorafenib*

Year 5 (2007-08)

Panka, David

Cho, Daniel

Mier, James

BIDMC

Potential Synergy Between Triterpenoids and NADPH Oxidase Inhibitors in the Treatment of RCC

Sukhatme, Vikas

BIDMC

LDH-A Inhibitors for the Treatment of Fumarate Hydratase (FH) Associated Hereditary Leiomyomatosis and RCC (HLRCC)

Zimmer, Michael

MGH

Identification of Novel Proteins that inhibit HIF mRNA Translation

Libermann, Towia

Sukhatme, Vikas

BIDMC

Identification of new drugs for treatment of RCC patients using Gene Signatures and the Connectivity Map Database

Extension Year (2008-09)

Cho, Eunyoung

Choueiri, Toni

HSPH

DFCI

Analgesic Use and the Risk of RCC

Bhatt, Rupal

BIDMC

Role of defects in IFNg signaling in escape from VEGFR inhibition