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Research Programs

Clinical-based Research


Recent Publications

Recent Publications of Note

1) Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk D-I, Tsung EF, Cai Z, Alberta JA, Cheng L-P, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, and Ma Q. Mouse Brain Organization Revealed through Direct Genome Scale Transcription Factor Expression Analysis. Science 2004; 306:2255-2257.

This paper presents a genome-wide catalogue of the transcription factors encoded in the murine and human genomes, together with an in situ hybridization atlas of transcription factors expressed in spatially or temporally restricted ways during brain development. The data are available on line in a searchable database.

2) Muroyama Y, Fujiwara Y, Orkin SH, and Rowitch DH. Specification of Astrocytes by bHLH Protein SCL in a Restricted Region of the Neural Tube. Nature 2005 438: 360-363.

Much excitement has been generated in recent years over cloning and characterization of Olig1 and Olig2, a pair of bHLH transcription factors that are both necessary and sufficient for development of oligodendrocytes from uncommitted neural progenitor cells. This manuscript describes a bHLH transcription factor that plays an equivalent role in development of astrocytes, the other major type of macroglial cell in the vertebrate central nervous system.

3) Aghi M, Rabkin S, and Martuza R. The Effect of Chemotherapy-Induced DNA Repair on Oncolytic Herpes Simplex Viral Replication. J. Neurosci 2005 (in press).

This manuscript shows that viruses can be engineered to take advantage of specific cancer cell pathways and to synergize with peripherally given pharmaceuticals.