1. Program in Molecular and Genetic Epidemiology, HSPH
Director: David Hunter, M.B.B.S., M.P.H., Sc.D.,Vincent L. Gregory Professor of Cancer Prevention
2. NCI BPC3 Study
The National Cancer Institute (NCI)’s Breast and Prostate Cancer and Hormone-related Gene Variants Cohort Consortium (“BPC3 Study”) is a multi-institutional study of breast and prostate cancer risk in relation to genetic polymorphisms and gene-environment interactions that affect hormone metabolism.
The study comprises six large prospective cohorts:
The BPC3 Study is a collaborative study using prospective plasma samples, genetic material, anthropometric measurements, and extensive questionnaire data on diet, physical activity, exogenous hormone use, smoking, and other lifestyle factors from over 740,000 men and women. In particular, 8,850 prostate cancer patients and 6,160 breast cancer patients are included in the study. The Study also includes extensive resequencing and haplotype definition on 55 biological candidate genes at three Genomics Centers: (1) Centre d'Etude du Polymorphisme Humain (CEPH), (2) the Broad Institute of MIT and Harvard, and (3) the NCI Core Genotyping Facility.