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Research Programs

Discipline-based Programs

Translational Pharmacology and Early Therapeutic Trials

Collaborative Interactions

Collaborative Interactions

The creation of DF/HCC has significantly enhanced efforts to obtain funding of multi-investigator grants. In turn, work supported by these grants has helped to spark new collaborations among Program members. Examples of such grants include:

Grant# Grant Title Principal Investigator Institution Project List Number of institutions involved
UO1-CA62490 Phase I Trials of New Anti-Cancer Agents Donald Kufe DFCI Conduct Phase I, I-II pharmacokinetic /pharmacodynamic trials of new cytotoxic agents, signal transduction inhibitors, differentiating agents and angiogenesis inhibitors, with correlative laboratory and imaging studies to define biological endpoints and mechanisms. DFCI
MGH
BIDMC
BWH
CHB
R21-CA101712 Overcoming Barriers to Minority Recuritment to Clinical Trials Bruce Chabner MGH The purpose of this grant is to develop new approaches to the recruitment of minority patients to clinical trials. The grant has completed its first year with 26 patients referred and 5 on active treatment. MGH
DFCI
BIDMC
BWH
P50-CA100707 Myeloma SPORE Kenneth Anderson DFCI Project: Kufe. MUC1 as a therapeutic target in multiple myeloma. DFCI
BIDMC
HMS
P50-CA101942 Renal SPORE Micheal Atkins BIDMC Project: Kufe/Avigan. Dendritic cell/tumor fusions in conjunction with IL-12 as novel immunotherapy for renal cancer. DFCI
BIDMC
MGH
P50-CA105009 Ovarian Cancer SPORE Daniel Cramer BWH Project: Kufe. Novel immunotherapeutic approaches for ovarian cancer. DFCI
BIDMC
MGH
BWH
P50-CA93683 Skin Cancer SPORE Thomas Kupper BWH Project: Kufe/Avigan. Direct comparison of dendritic cell vaccines in melanoma. DFCI
BIDMC
MGH
BWH
PO1-CA78378 Myeloma PO-1 Kenneth Anderson DFCI Project: Kufe/Avigan. Development of myeloma vaccines. DFCI
BIDMC
PO1-CA6848 ALL PO-1 Stephen Sallan DFCI Project: Kufe/Supko. Therapeutic index of ALL. DFCI
MGH
CHB
UO1-CA105689 NABTT Tracy Batchelor MGH Project: Supko. Pharmacokinetics. MGH
DAMD-03-1-0487 DOD Breast Cancer Grant Donald Kufe DFCI Fusions of breast carcinoma and dendritic cells as a vaccine for the treatment of metastatic breast cancer. DFCI
BIDMC
MGH