Research

Nabeel Bardeesy, PhD and Andy Aguirre have developed a histologically and genetically accurate mouse model of pancreatic adenocarcinoma that harbors pancreas-specific lesions in the signature pancreatic cancer genes Kras and Ink4a/Arf (Genes and Development 2003). | more

Studies from the laboratory of Sarah Thayer, MD, PhD, demonstrated abnormal regulation of Hedgehog (Hh) pathway signaling in both pancreatic adenocarcinoma and PanIN (Nature, 2003). | more

Lepourcelet et al., Development. 2005 Jan;132(2):415-27.   Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF). | more

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