Research Programs
Disease-based Programs
Prostate Cancer
Collaborative Interactions
Collaborative Interactions
Large Collaborative Grants
The creation of DF/HCC has significantly enhanced our efforts to obtain funding of multi-investigator grants. In turn, work supported by these grants has helped to spark new collaborations among Program members. Examples of such grants include:
| Grant# | Grant Title | Principal Investigator | Project List | Number of Investegators Involved |
| UO1 CA84995-01 | Director's Challenge Grant - Mollecular Staging of Prostate and Lung Cancers | D. Livingston - DFCI | Molecular staging of prostate and lung cancers | 3: DFCI, BWH, MIT |
| PO1 CA89021-01 | The Role of PTEN and the P13K Pathway in Prostate Cancer | L. Cantley - BIDMC | Animal models of prostate cancer built around mutant PI3K and Akt | 3: BIDMC, BWH, DFCI |
| P50 CA090381-01A1 | DF/HCC Prostate Cancer SPORE | P. Kantoff - DFCI | Genetic epidemiology Side effects of ADT Molecular staging AR | 7: BIDMC, BWH, DFCI, HSPH, MGH, CHB, Broad Institute |
| R01 CA85074 01 | Study of Molecular Epidemiology of Prostate Cancer | M. Stampfer - BWH | Molecular and environmental epidemiology | 3: BWH, DFCI, HSPH |
Career Development, Pilot Project and Nodal Awards
These grants, funded through the SPORE mechanism, DF/HCC nodal point grant program or Institutional support, have helped to create links between the Program and certain discipline- and other disease-based programs.
| Award Type | PI | Program | Institution | Project Title | DIR Award |
| Career Development | Pradip Majumder | - Prostate | DFCI | Discovery of Molecular Markers for Prostate Cancer | $40,000.00 |
| Career Development | Matthew Feedman | - Cancer Genetics - Prostate |
MGH | A Genomic Approach to Identifying Inherited Variation at the HPC1 Locus in Sporadic Prostate Cancer | $40,000.00 |
| Career Development | Vijay Yajnik | MGH | DOCK4 in Prostate Cancer Progression | $40,000.00 | |
| Career Development | Timothy Gilligan | - Prostate | DFCI | Prostate Cancer Screening Decision Aid for African-American Men in Boston | $30,000.00 |
| Career Development | Jean Zhao | DFCI | Identification of Anti-Tumor Agents that Target the P13K Pathway in Genetically Engineered Human Prostate Tumor Cells | $40,000.00 | |
| Career Development | Dror Michealson | - Prostate - Renal |
MGH | Bone Metabolism in Men with Advanced Prostate Cancer: Effects of Disease and Treatment | $30,000.00 |
| Career Development | Jaqueline Banyard | CHB | Analysis of Collagen XXIII Expression in Human Prostate Cancer | $40,000.00 | |
| Career Development | Levi Garraway | - Prostate - Cancer Genetics |
HMS | A 'Functional Proteomics' Study of Hormone Independence in Prostate Cancer | $50,000.00 |
| Pilot Project | Anders Naar | - Prostate - Cancer Cell Biology |
MGH | The Role of the Androgen Receptor in the Development and Progression of Prostate Cancer | $50,000.00 |
| Pilot Project | William Hahn | - Prostate | DFCI | Discovery of Novel Prostate Cancer Therapeutics Using Reverse and Chemical Genetics | $50,000.00 |
| Pilot Project | Chris Carpenter | - Prostate | BIDMC | The Role of Bmx in Prostate Cancer | $40,000.00 |
| Pilot Project | Aria Olumi | - Prostate - Renal |
BIDMC | The Role of Anti-Apoptotic Factors in Evasion of Prostate Tumors from TRAIL-Induced Apoptosis | $50,000.00 |
| Pilot Project | Towia Liberman | - Prostate - Breast - Renal |
BIDMC | Deregulated IL-6 Gene Expression in Prostate Cancer: A Target for Therapeutic Intervention | $50,000.00 |
| Pilot Project | Muneesh Tewari/Patrick Hu | - Prostate - GI - Cancer Cell Biology - Cancer Genetics |
DFCI | Identification and Validation of Novel Drug Targets in the Insulin-Like Growth Factor-1 Signaling Pathway Using C. Elegans | $50,000.00 |
| Pilot Project | Matthew Smith/ David Nathan | - Prostate - Renal |
MGH | Cardiovascular Disease Risk Associated w/ Androgen Deprivation Therapy for Prostate Cancer | $50,000.00 |
| DF/HCC Development Award | Ralf Weissleder | - Cancer Imaging - Prostate - Neuro-Oncology - GI |
MGH | Detection of prostate cancer by molecular signatures | |
| Pilot Project | Jon C. Aster | - Pathology - Leukemia |
BWH | JAGGED1 in human prostate cancer | $40,000.00 |
| Career Development | Lorelei Mucci | - Cancer Epidemiology | HSPH | Developing a Composite Biomarker for Agressive and Indolent Prostate Cancer | $40,000.00 |
| Career Development | Matthias D. Hoffer | - Pathology - Cancer Genetics |
BWH | Developing a Molecular Signature of Aggressive Prostate Cancer Based on Genomic Aberration and Expression | $40,000.00 |
