The DF/HCC Biostatistics Core is a shared resource supporting consultation on biostatistics related to basic, clinical, and translational cancer research. Its mission is to: Ensure that experimental designs, study monitoring, and data analyses take advantage of robust, efficient methods that reflect best practices in biostatistics; Support peer reviewed (NIH or foundation) grant proposals; and Assist with planning and analysis of pilot and small scale studies.
- Biostatistical consulting in the planning, conduct, analysis, and reporting of:
- - Clinical trials—the Core consults on and reviews all clinical protocols activated by DF/HCC
- - Epidemiologic and population-based studies, and studies in somatic genetics and the risk of cancer
- - Experiments in the biology of cancer, including genomic experiments and laboratory and animal studies
- - Translational research studies with combined measurements on clinical and biological parameters
- Advice and support for DF/HCC members’ preparation of grant applications
- Scientific computing for data analysis and scientific graphics necessary for analyses of epidemiological, clinical, basic science, and genomic studies
- Advice and consultation to the Quality Assurance Office for Clinical Trials on efficient and accurate database design and management of clinical research data
- Advice and consultation to the Office for the Protection of Research Risks (OPRS) in the scientific reviews of clinical trials through membership on the various DF/HCC Scientific Review Committees.
- Education for DF/HCC members in study design, data collection, computerization, and statistical methods for laboratory, clinical, and population-based studies
Work Priorities and Requirements of Users
In general, the priorities for statistical work (from highest to lowest) are:
- Grant proposal preparation
- Abstracts for national and international meetings*
- Clinical protocol design and review
- Laboratory, animal, and epidemiology study design and review
- Short term consults
- Study monitoring, analysis, manuscript preparation, and replies to manuscript reviews
- Education of users
* Please note that the Core will only work on analysis for an abstract presentation at a national or international meeting if the Core worked on and/or reviewed the abstract submission (before the abstract was submitted).
In order to better manage statistical work on projects with external deadlines, the Biostatistics Core requires that users:
- Notify the Core at least 6 months before the grant deadline for competing NIH P series, U series, and SPORE grants (and similar sized foundation grants)
- Notify the Core at least 2 months before the grant deadline for competing NIH R series and K series grants (and similar sized foundation grants)
- Provide the Core at least 1 month before the deadline with data sets for an analysis for an abstract submission to a national or international meeting (e.g., ASCO, AACR, ASH, ASTRO)
If research supported by this core facility results in publication, please acknowledge this support by including the following in your publication(s):
"We thank Dana-Farber/Harvard Cancer Center in Boston, MA, for the use of the Biostatistics Core, which provided __________ service. Dana-Farber/Harvard Cancer Center is supported in part by an NCI Cancer Center Support Grant # NIH 5 P30 CA06516."