Specific Aim:  to establish a tissue and pathology resource that will be available to SPORE investigators that is linked to clinical data via a secure data management system. 

Goal:  to acquire and link clinical data collected through the Clinical Research Information System (CRIS) with prospectively collected tissue and blood samples.

Expertise:  This Core service provides pathological evaluation of specimens, microdissection, RNA amplification, RNA and DNA isolation from microdissected and macrodissected tissue samples, quantitative real-time PCR using RNA derived from frozen, and FFPE samples and immunohistochemistry

MGH Tumor Bank:  collects, stores and processes breast core biopsy samples in conjunction with SPORE neoadjuvant therapeutic trials.  In addition to frozen tissue samples, the MGH Tumor Bank provides access to all formalin-fixed paraffin-embedded breast cancer, normal breast and benign breast disease tissue.  The Bank also provides SPORE researchers’ access to amplified RNA derived from malignant cells of the various stages of breast cancer progression. 

BWH Tumor Bank:  collects breast tumor and matched normal tissues, normal breast tissues from reduction mammoplasties, and metastatic breast cancer specimens.  These samples can be provided to investigators as required as fresh tissue for cell sorting or tissue culture experiments, as frozen tissue or frozen sections, or as extracted DNA, RNA or protein.  The Bank collects, stores and processes breast core biopsy samples in conjunction with SPORE neo-adjuvant trials.

SPORE Serum and Blood Repository (SSBR):  As of June 2007, 7,917 patients have been consented and have given blood samples from which serum or plasma and whole blood have been collected and stored.  In addition, 3,697 consented high-risk patients have provided blood samples.

Clinical Trials:  collection of specimens from breast cancer patients enrolled in clinical treatment studies.  As of June 2007, 31 clinical trials have used this Core for sample collection and storage.

To order tissue, please complete this Breast Tissue Request Form.

To order blood, please complete this Blood Bank Request Form.

Andrea Richardson, MD, PhD – BWH
Stuart J. Schnitt, MD – BIDMC
Dennis Sgroi, MD – MGH
Penelope Miron, PhD – DFCI

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