Projects

Breast SPORE projects fall into two categories: those that start with a clinical trial and develop biologic questions designed to improve treatment outcome (“treatment”); and those that begin with a biological question about breast cancer and attempt to answer that question by studying patients, their cells, and their tissues (“tissues”).

The Breast SPORE encompasses six projects supported by five scientific Cores and an administrative Core.

• Project 1 — Biology and treatment of BRCA1 mutant and sporadic basal-like cancers (treatment)
• Project 2 — Targeted combinations for HER2 – positive breast cancer biology (treatment)
• Project 3 — Role of coregulators in response to aromatase inhibitors (treatment)
• Project 4 — Biology of metastasis in breast cancer patients (tissues)
• Project 5 — The role of stromal cells and stromal-epithelial interaction in the early stages of breast tumor progression: implications for risk, prevention, and treatment (tissues)
• Project 6 — Variation in receptor tyrosine kinases and breast cancer risk (tissues)
  
  

These six projects are supported by the following Cores:

• Tissue and Pathology
• Clinical Studies
• Cohort Studies
• Biostatistics
• Bioinformatics
• Communication, Planning, and Administration
  
  

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