Aim 1:  Determine the function of AIB1 and other coregulators in altering ER activity in breast cancer cells in culture under low estrogen conditions.

Aim 2:  Study the role of AIB1 and its interaction with growth factor signaling pathways in mediating the response to AIs in a transgenic mouse model.

Aim 3:  Perform brief exposure pre-surgical trials of AIs in postmenopausal women with newly diagnosed ER+ breast cancer.

Key Personnel:

Myles Brown, MD – DFCI
Steve Come, MD –BIDMC
Stuart J. Schnitt, MD – BIDMC

Recent Publications:

Eeckhoute, J., Keeton, E.K., Lupien, M., Krum, S.A.,Carroll, J.S., Brown, M. A positive cross-regulatory loop ties GATA-3 to estrogen receptor  expression in breast cancer. Cancer Res 2007 Jul 1;67(13):6477-83.

Frietze, S., Lupien, M., Silver, P.A., and Brown, M. CARM1 regulates estrogen stimulated breast cancer growth through the regulation of E2F1. Cancer Res 2008 Jan 1;68(1):301-6.

Lupien, M., Eeckhoute, J., Meyer, C.A., Wang, Q., Zhang, Y., Li, W., Carroll, J.S., Liu, X.S. and Brown, M. FoxA1 translates epigenetic signatures into enhancer driven lineage-specific transcription. Cell, 132 (6): 958-70, 2008.

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