Aim 1:  Determine the function of AIB1 and other coregulators in altering ER activity in breast cancer cells in culture under low estrogen conditions.

Aim 2:  Study the role of AIB1 and its interaction with growth factor signaling pathways in mediating the response to AIs in a transgenic mouse model.

Aim 3:  Perform brief exposure pre-surgical trials of AIs in postmenopausal women with newly-diagnosed ER+ breast cancer.

Myles Brown, MD – DFCI
Steve Come, MD –BIDMC
Stuart J. Schnitt, MD – BIDMC

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