Aim 1:  Determine the genetic relatedness of primary breast cancer to matched metastatic deposits in the same patient.

Aim 2:  Investigate the ability to predict that site of predominant metastatic disease based upon expression profiles in the primary cancer.

Sridhar Ramaswamy, MD – MGH
Andrea Richardson, MD, PhD – BWH
Nancy U. Lin, MD – DFCI
Stuart G. Silverman, MD – BWH
Zhigang (Charles) Wang, PhD – BWH

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