Aim 1:  To determine if stromal cells from uninvolved breast tissue from patients with breast cancer are more conducive to cancer development than stromal cells of women without cancer.

Aim 2:  To identify gene expression signatures of stromal cells associated with cancer, stromal cells from uninvolved breast tissue from patients with breast cancer, and stromal cells from breasts without cancer.

Aim 3:  To determine in human breast tissue samples if there is an association between stromal markers and epithelial lesions associated with increased breast cancer risk, and to determine if there are stomal markers that can be used as independent risk indicators.