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SPOREs

Breast

Projects

Discovering susceptibility factors by interactions between functional screening and population studies

Aim 1:  Examine if common genetic variants of EGF-R ERBB2, CSF-1R and IGF-1R are associated with increased risk of breast cancer.

Aim 2:  Examne if rare variants of EGF-R, ERBB2, CSF-1R and IGF-1R display distinct functional activities and if so, whether they are associated with familial breast cancer.

Aim 3:  Protein expression status in tissue microarrays of breast cancer tumors.

Aim 4:  Plasma levels of protein ligands are associated with subsequent breast cancer risk.

Key Personnel

Joan S. Brugge, PhD – HMS
Sue Hankinson, ScD, MPH – BWH
Matthew L. Freedman, MD – DFCI
Alexander Miron, PhD – DFCI
Rulla Tamimi, ScD – BWH

Recent Publications

Tamimi RM, Byrne C, Colditz GA, Hankinson SE. Endogenous hormone levels, mammographic density, and subsequent risk of breast cancer in postmenopausal women. J Natl Cancer Inst 2007;99(15):1178-87.

Tamimi RM, Brugge JS, Freedman ML, Miron A, Iglehart JD, Colditz GA, et al. Circulating colony stimulating factor-1 and breast cancer risk. Cancer Res 2008;68(1):18-21.

Tamimi RM, Cox D, Kraft P, Colditz GA, Hankinson SE, Hunter DJ. Breast cancer susceptibility loci and mammographic density (under review).