SPOREs
Breast
Projects
Discovering susceptibility factors by interactions between functional screening and population studies
Aim 1: Examine if common genetic variants of EGF-R ERBB2, CSF-1R and IGF-1R are associated with increased risk of breast cancer.
Aim 2: Examne if rare variants of EGF-R, ERBB2, CSF-1R and IGF-1R display distinct functional activities and if so, whether they are associated with familial breast cancer.
Aim 3: Protein expression status in tissue microarrays of breast cancer tumors.
Aim 4: Plasma levels of protein ligands are associated with subsequent breast cancer risk.
Key Personnel
Joan S. Brugge, PhD – HMS
Sue Hankinson, ScD, MPH – BWH
Matthew L. Freedman, MD – DFCI
Alexander Miron, PhD – DFCI
Rulla Tamimi, ScD – BWH
Recent Publications
Tamimi RM, Byrne C, Colditz GA, Hankinson SE. Endogenous hormone levels, mammographic density, and subsequent risk of breast cancer in postmenopausal women. J Natl Cancer Inst 2007;99(15):1178-87.
Tamimi RM, Brugge JS, Freedman ML, Miron A, Iglehart JD, Colditz GA, et al. Circulating colony stimulating factor-1 and breast cancer risk. Cancer Res 2008;68(1):18-21.
Tamimi RM, Cox D, Kraft P, Colditz GA, Hankinson SE, Hunter DJ. Breast cancer susceptibility loci and mammographic density (under review).
