SPOREsBreastProjectsProject 6: Variation in Receptor Tyrosine Kinases and Breast Cancer RiskAim 1: Examine if common genetic variants of EGF-R ERBB2, CSF-1R and IGF-1R are associated with increased risk of breast cancer. Aim 2: Examne if rare variants of EGF-R, ERBB2, CSF-1R and IGF-1R display distinct functional activities and if so, whether they are associated with familial breast cancer. Aim 3: Protein expression status in tissue microarrays of breast cancer tumors. Aim 4: Plasma levels of protein ligands are associated with subsequent breast cancer risk. Key PersonnelJoan S. Brugge, PhD – HMS |
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