Project 1: Improved pre-operative staging of pancreatic cancer
Principal Investigator: Sarah Thayer, MD, PhD (MGH) 

Project 2: Molecular fluorescent imaging for the early detection of colorectal neoplasms
Co-Principal Investigators: Raju Kucherlapati, PhD (HMS) and Umar Mahmood, MD, PhD (MGH)

Project 3: Defining optimal doses of vitamin D for chemoprevention in Blacks
Principal Investigator: Charles Fuchs, MD, MPH (DFCI)

Project 4: The role of PI3-Kinase signaling pathway in defining sensitivity and resistance to anti-EGFR therapy in colorectal cancer
Co-Principal Investigators: Lewis Cantley, PhD (BIDMC), Jeffrey Engelman, MD, PhD (MGH), and Jeffrey Meyerhardt, MD, MPH (DFCI)

Project 5: Targeted therapy resistance mechanisms in gastrointestinal stromal tumor (GIST)
Principal Investigator: George Demetri, MD (DFCI)