SPOREs
Ovarian
Projects
Project 1: Modifiable risk factors and gene/environmental interactions in ovarian cancer
Specific Aims
- By free radical damage generated from chronic inflammation, genital exposure to talc increases the risk for ovarian cancer and the association may be more apparent in women with the “null” variant of GSTM1, “slow” variant of NAT2, and “G” variant of MPO
- By protecting against prostaglandin-induced upregulation of aromatase or other mechanisms, ovarian cancer risk is reduced by acetaminophen, ibuprofen, aspirin, or other anti-inflammatory drugs and risk may be modified by genes in CYP2C9, UGT1A6, or aromatase pathways
- By enhancing steroid production, caffeine consumption increases ovarian cancer risk and the association may be modified by menopausal status, cholesterol consumption, hormone use, smoking, or caffeine metabolism involving CYP1A1, CYP1A2, CYP2A6, and NAT2
Papers published
Terry KL, Titus-Ernstoff L, McKolanis JR, Welch WR, Finn OJ, Cramer DW. Incessant ovulation, mucin 1 immunity, and risk for ovarian cancer. Cancer Epidemiol Biomarkers Prev 2007;16:30-5.
Gates MA, Tworoger SS, Hecht JL, De Vivo I, Rosner B, Hankinson SE. A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer. Int J Cancer 2007 (Epub ahead of print).
Ye B, Aponte M, Dai Y, Li L, Ho MC, Vitonis A, Edwards D, Huang TN, Cramer DW. Ginkgo biloba and ovarian cancer prevention: Epidemiological and biological evidence. Cancer Lett 2007;251:43-52.
Gates MA, Tworoger SS, Terry KL, Titus-Ernstoff L, Rosner B, De Vivo I, Cramer DW, Hankinson SE. Talc use, variants of the GSTM1, GSTT1, and NAT2 genes, and risk of epithelial ovarian cancer. Cancer Epidemiol Biomarkers Prev 2008.
Danforth KN, Tworoger SS, Hecht JL, Rosner BA, Colditz GA, Hankinson SE. A prospective study of postmenopausal hormone use and ovarian cancer risk. Br J Cancer 2007;96:151-6.
Tworoger SS, Lee IM, Buring JE, Rosner B, Hollis BW, Hankinson SE. Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of incident ovarian cancer. Cancer Epidemiol Biomarkers Prev 2007;16:783-8.
Tworoger SS, Lee IM, Buring JE, Pollak MN, Hankinson SE. Insulin-like growth factors and ovarian cancer risk: a nested case-control study in three cohorts. Cancer Epidemiol Biomarker Prev 2007;16:1691-5.
Tworoger SS, Fairfield KM, Colditz GA, Rosner BA, Hankinson SE. Association of oral contraceptive use, other contraceptive methods, and infertility with ovarian cancer risk. Am J Epidemiol 2007;166:894-901.
Cramer DW, Welch WR, Berkowitz RS, Godleski JJ. Presence of talc in pelvic lymph nodes of a woman with ovarian cancer and long-term genital exposure to cosmetic talc. Obstet Gynecol 2007;110:498-501.
Pinheiro SP, Cramer DW. Non-genomic biomarkers of risk in ovarian cancer. Dis Markers 2007;23:355-66.
Tworoger SS, Lee IM, Buring JE, Hankinson SE. Plasma androgen concentrations and risk of incident ovarian cancer. Am J Epidemiol 2008;167:211-8.
Tworoger SS, Gertig DM, Gates MA, Hecht JL, Hankinson SE. Caffeine, alcohol, smoking, and the risk of incident epithelial ovarian cancer. Cancer 2008;112:1169-77.
Gates MA, Tworoger SS, Terry KL, De Vivo I, Hunter DJ, Hankinson SE, Cramer DW. Breast cancer susceptibility alleles and ovarian cancer risk in two study populations. Int J Cancer 2008 (in press).
Kotsopoulos J, Vitonis AF, Terry KL, De Vivo I, Cramer DW, Hankinson SE, Tworoger SS. Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer. Cancer Causes Control (in press).
Comments: For the renewal application we plan to continue Project 1 with the focus of exploring whether most risk factors for ovarian cancer operate by enhancing or dampening immunity against the surface glycoprotein and tumor marker, human
mucin 1.
