Project 1: ABCB5 and melanoma stem cells: Implications for prognosis and therapeutic targeting
Principal Investigator: George Murphy, MD (BWH)
Co-Investigator: Marcus Frank, MD (BWH)

Project 2: Molecular signatures of melanoma: Predicting response to therapy and targeting the MITF pathway
Principal Investigator: Todd Golub, MD (DFCI/Broad)

Project 3:  Generation of a therapeutic antibody directed against CCR4 for patients with advanced cutaneous T cell lymphoma
Principal Investigator: Thomas Kupper, MD (BWH)
Co-Investigator: Wayne Marasco, MD, PhD (DFCI)

Project 4: Targeting RAF in melanoma: Mechanisms for effect and resistance and opportunities for rational combination therapy
Principal Investigator: James Mier, MD (BIDMC)
Co-Investigator: Levi Garraway, MD, PhD (DFCI)

Project 5: Correlating environmental and genetic risk factors with molecular signatures in melanoma
Principal Investigator: David Hunter, MPH, ScD (HSPH)
Co-Investigators: Hensin Tsao, MD, PhD (MGH) and Lyn Duncan, MD (MGH)