Preliminary Program:
8:00am-8:30am
Registration (Jimmy Fund Auditorium Lobby)
8:30am-8:45am
Introduction
Anders Näär, PhD, MGH Cancer Center/HMS Cell Biology
Nika Danial, PhD, DFCI/HMS Medicine
8:45am-10:15am
Kevin Marks, PhD, Agios Pharmaceuticals - "Identifying metabolic vulnerabilities of cancer cells"
Pere Puigserver, PhD, DFCI/HMS Cell Biology - "Mitochondrial heterogeneity in melanoma metastasis"
Nika Danial, PhD, DFCI/HMS Medicine - "Causes and consequences of metabolic fuel choice in cancer"
10:15am-10:30am
Coffee break
10:30am-12:30pm
Bruce Spiegelman, PhD, DFCI/HMS Cell Biology - "Control of oxidative metabolism through PGC1alpha"
Tobi Walther, PhD, HHMI/HSPH/HMS Cell Biology - "The phase of fat: mechanisms and physiology of neutral lipid storage"
Othon Iliopoulos, MD, MGH Cancer Center/HMS Medicine - "Targeting HIF-VHL mediated reprogramming of cancer metabolism"
Marcia Haigis, PhD, HMS Cell Biology - "New roles for mitochondria in cancer"
12:30pm-1:45pm
Lunch break (DFCI Yawkey 306)
1:45pm-3:15pm
Alex Toker, PhD, BIDMC/HMS Pathology - "Reprogramming of metabolic pathways by PI 3-Kinase and AKT signaling"
Julie Losman, MD, PhD, DFCI/HMS Medicine - "Epigenetic targets of mutant IDH and R-2HG in AML"
Raul Mostoslavsky, MD, PhD, MGH Cancer Center/HMS Medicine - "Linking epigenetics, metabolism and cancer: Clues from SIRT6"
3:15pm-3:30pm
Coffee break
3:30pm-5:00pm
Massimo Loda, MD, DFCI/HMS Pathology - "Metabolic dependencies in prostate cancer: regulation and targeting of lipogenesis"
Anders Näär, PhD, MGH Cancer Center/HMS Cell Biology - "Targeting the lipogenic transcription factor SREBP in cancers"
Joan Brugge, PhD, Harvard Ludwig Cancer Center/HMS Cell Biology - "Oxidative stress defenses in cancer"
5:00pm-6:00pm
Networking Reception w/ light fare and beverages
(DFCI Yawkey Building, Room 308)
Sponsored by:
the DF/HCC Cancer Cell Biology Program & Agios Pharmaceuticals