LC Virtual Symposium

Zoom Link: https://dfci.zoom.us/j/869538040?pwd=NGhrdDNuUE5YWXdrb3hJUjNpRm1MZz09
Password: dfhcc2020

Call-In Numbers (US):  +1 312 626 6799 or +1 929 205 6099 or +1 253 215 8782 or +1 301 715 8592 or +1 346 248 7799 or +1 669 900 6833

International numbers available: https://dfci.zoom.us/u/acM1dyE4Bv

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The DF/HCC Connect:Science seminar series offers remote participation through Zoom (create an account here) to pull our community of faculty, trainees, and lab staff together during this difficult time and it promotes engagement during these next several weeks. We plan to involve speakers who are leaders in cancer biology, immune oncology and other fields from across the world. This seminar series will be broadcast to researchers around the globe and recorded for subsequent viewing.

The series which began on March 23, has switched to a twice weekly format as of July 6, and will now be held every Tuesday and Thursday. All talks will be begin at 12 PM EST.

For more information about this seminar series, email: dfhcc@partners.org

Organized by:

Upcoming Seminars

September 24

Cardio-Oncology: Cardiovascular Sequelae of Cancer Immunotherapies – From Bench to Bedside

HOST: Kristopher Sarosiek      

  • Javid Moslehi, MD
    JAVID MOSLEHI, MD

    Vanderbilt University

September 29

Oncogenic Pathways in Biliary Tract Cancer

HOST: Daniel Haber     

  • Nabeel El-Bardeesy, PhD
    NABEEL EL-BARDEESY, PHD

    Mass General Cancer Center

October 1

What chemotherapy can tell us about cancer

HOST: DAVID WEINSTOCK      

  • Michael Hemann, PhD
    MICHAEL HEMANN, PHD

    Koch Institute for Integrated Cancer Research at the Massachusetts Institute of Technology

October 6

LAP and LANDO: Non-canonical functions of autophagy proteins in anti-cancer immunity and Alzheimer's Disease

HOST: Kristopher Sarosiek     

  • Douglas Green, PhD
    DOUGLAS GREEN, PHD

    St. Jude Children's Research Hospital

October 8

Enabling the robust characterization of spatial gene expression architecture in tissue sections at increased resolution using Bayesian modeling

HOST: Rafael Irizarry     

  • Raphael Gottardo, PhD
    RAPHAEL GOTTARDO, PHD

    Fred Hutchinson Cancer Research Center

October 15

BEACON TOWERS OF THE GREAT WALL: NEW NUCLEOTIDE-SENSING MEMBRANE PROTEINS AND THE INFLAMMATORY MICROENVIRONMENT

HOST: Judy Lieberman      

  • Shicheng Su, PhD
    SHICHENG SU, PHD

    Sun Yat Sen University in Guangzhou China

October 20

Reprogramming T Cells with CRISPR

HOST: Xiaole Shirley Liu     

  • Alexander Marson, MD, PhD
    ALEXANDER MARSON, MD, PHD

    UCSF Helen Diller Family Comprehensive Cancer Center

October 22

Uncovering new targets of the LKB1/STK11 tumor suppressor in lung cancer

HOST: Marcia Haigis     

  • Reuben Shaw, PhD
    REUBEN SHAW, PHD

    Salk Institute for Biological Studies

October 27

Exploitable changes in the BCL-2 network during tumor evolution

HOST: Kristopher Sarosiek    

  • Kris Wood, PhD
    KRIS WOOD, PHD

    Duke Cancer Institute

October 29

The QuEST for an effective immunotherapy for Prostate Cancer

HOST: Steve Balk   

  • James Gulley, MD, PhD
    JAMES GULLEY, MD, PHD

    NCI/CCR

November 5

TIME and Age: The impact of Age on the breast cancer Tumor Immune MicroEnvironment and therapeutic response

HOST: KORNELIA POLYAK     

  • Sandra McAllister, PhD
    SANDRA MCALLISTER, PHD

    Brigham And Women's Hospital

November 10

TALK TITLE TBD

HOST: Alejandro Gutierrez    

  • Karen Adelman, PhD
    KAREN ADELMAN, PHD

    Harvard Medical School

November 12

TALK TITLE TBD

HOST: Rafael Irizarry     

  • Nabihah Tayob, PhD
    NABIHAH TAYOB, PHD

    Dana-Farber Cancer Institute

November 17

TALK TITLE TBD

HOST: Marcia Haigis     

  • Raul Mostoslavsky, MD, PhD
    RAUL MOSTOSLAVSKY, MD, PHD

    Massachusetts General Hospital

November 19

SPEAKER AND TALK TITLE TBD

HOST: TBD    

November 24

SPEAKER AND TALK TITLE TBD

HOST: TBD    

December 1

TALK TITLE TBD

HOST: Kristopher Sarosiek     

  • Yael Mosse, MD
    YAEL MOSSE, MD

    Children's Hospital of Philadelphia Research Institute

December 3

TALK TITLE TBD

HOST: David Fischer    

  • Elaine Fuchs, PhD
    ELAINE FUCHS, PHD

    Howard Hughes Medical Institute

December 8

SPEAKER AND TALK TITLE TBD

HOST: TBD    

December 10

TALK TITLE TBD

HOST: Steve Balk    

  • Matthew Freedman, MD
    MATTHEW FREEDMAN, MD

    Dana-Farber Cancer Institute

Past Seminars

September 22

The yin and yang of an inflamed tumor microenvironment: Is there a relationship between lymphangiogenesis, metastasis, and immune priming

HOST: Kornelia Polyak     

  • Melody Swartz, PhD
    MELODY SWARTZ, PHD

    University of Chicago



the recording to this talk WILL NOT BE available.
we apologize for the inconvenience. 
    

September 17

Organoids to model human disease

HOST: Alejandro Gutierrez     

  • Hans Clevers, MD, PhD
    HANS CLEVERS, MD, PHD

    Hubrecht Institute

September 15

The double-edged sword of cellular senescence

HOST: Marcia Haigis     

  • Judith Campisi, PhD
    JUDITH CAMPISI, PHD

    Lawrence Berkeley National Laboratory

September 10

Focal radiotherapy to convert the tumor into an in situ vaccine

HOST: Kristopher Sarosiek       

  • Silvia Formenti, MD
    SILVIA FORMENTI, MD

    Weill Cornell Medicine

September 8

Polymerase Theta Inhibitor Overcomes PARP Inhibitor Resistance

HOST: Ralph SCULLY

September 3

Hypoxia, Metabolism, and Tumor Progression

HOST: Marcia Haigis 

  • Celeste Simon, PhD
    CELESTE SIMON, PHD

    University of Pennsylvania Perelman School of Medicine

September 1

Monitoring with Data During the COVID-19 Pandemic

HOST: David Weinstock     

  • Rafael Irizarry, PhD
    RAFAEL IRIZARRY, PHD

    Dana-Farber Cancer Institute

August 27

Dissemination and metastatic dormancy of early evolved mammary cancer cells

HOST: Judith Agudo     

  • Julio Aguirre-Ghiso, MSc, PhD
    JULIO AGUIRRE-GHISO, MSC, PHD

    Icahn School of Medicine at Mount Sinai



the recording to this talk IS NO LONGER available.
we apologize for the inconvenience. 
    

August 25

Poetry in motion: Increased chromosomal mobility after DNA damage

HOST: David Weinstock    

  • Rodney Rothstein, PhD
    RODNEY ROTHSTEIN, PHD

    Columbia University

 

August 20

Unanticipated vulnerabilities of chemoresistant triple-negative breast cancer

HOST: Daniel Haber     

  • Leif Ellisen, MD, PhD
    LEIF ELLISEN, MD, PHD

    Mass General Cancer Center

August 18

Sequential Bayesian Designs for Rapid Learning in COVID-19 Clinical Trials 

HOST: Rafael Irizarry     

  • Frank Harrell, PhD
    FRANK HARRELL, PHD

    Vanderbilt University School of Medicine

August 13

Ubiquitin-dependent signaling in development and disease

HOST: Eric Fischer      

  • Michael Rape, PhD
    MICHAEL RAPE, PHD

    University of California, Berkeley

August 11

Relating single cell function to tissue structure in human health and disease using multiplexed ion beam imaging (MIBI)

HOST: Kornelia Polyak     

  • Michael Angelo, MD, PhD
    MICHAEL ANGELO, MD, PHD

    Stanford University

August 6

Synthetic Lethality of Wnt Pathway Activation and Asparaginase for Cancer Therapy

HOST: Sahand Hormoz    

  • Alejandro Gutierrez, MD
    ALEJANDRO GUTIERREZ, MD

    Dana-Farber Cancer Institute

August 4

Identifying therapeutic resistance mechanisms in cancer with single-cell data and machine learning

HOST: Aedin Culhane      

  • Elana Fertig, PhD
    ELANA FERTIG, PHD

    The Sidney Kimmel Comprehensive Cancer Center

July 30

Transposable elements in cancer

HOST: David Pellman      

  • Kathleen Burns, MD, PhD
    KATHLEEN BURNS, MD, PHD

    Dana-Farber Cancer Institute

July 28

PD-1 blockade in cancer therapy: mechanism-based biomarkers and new frontiers

HOST: Kornelia Polyak    

  • Suzanne Topalian, MD
    SUZANNE TOPALIAN, MD

    Sidney Kimmel Comprehensive Cancer Center

July 23

Regulation of disseminated tumor cell dormancy in brain by the perivascular niche

HOST: Judith Agudo     

  • Cyrus Ghajar, PhD
    CYRUS GHAJAR, PHD

    Fred Hutchinson Cancer Research Center

July 21

Targeting undruggable RAS for cancer treatment

HOST: Senthil Muthuswamy     

  • Channing Der, PhD
    CHANNING DER, PHD

    UNC Lineberger Comprehensive Cancer Center

July 16

Transcription of the genome: mechanisms and regulatory strategies

HOST: Eric Fischer    

  • Patrick Cramer, PhD
    PATRICK CRAMER, PHD

    MPI for Biophysical Chemistry

July 14

MIN-CIN’g the Genome: Microsatellite Instability drives Chromosome Instability 

HOST: David Pellman     

  • Andre Nussenzweig, PhD
    ANDRE NUSSENZWEIG, PHD

    NCI/CCR

July 9

Transcription factor cross-talk in Estrogen Receptor positive breast cancer

HOST: KORNELIA Polyak    

  • Jason Carroll, PhD
    JASON CARROLL, PHD

    Cancer Research UK Cambridge Institute, University of Cambridge

July 7

Ubiquitin and autophagy networks in health and disease

HOST: Eric Fischer    

  • Ivan Dikic, MD, PhD
    IVAN DIKIC, MD, PHD

    Goethe University Frankfurt

July 2

If you want to know how to treat cancer, ask the mitochondria

HOST: David Weinstock

  • Anthony Letai, MD, PhD
    ANTHONY LETAI, MD, PHD

    Dana-Farber Cancer Institute

June 30

TALK 1: Biology and therapeutic targeting of cohesin mutations in myeloid malignancies

TALK 2: Oncogenic mechanisms and therapeutic targeting of 2-hydroxyglutarate metabolism


  • Zuzana Tothova, MD, PhD
    ZUZANA TOTHOVA, MD, PHD

    Dana-Farber Cancer Institute

  • Andrew Intlekofer, MD, PhD
    ANDREW INTLEKOFER, MD, PHD

    Memorial Sloan Kettering Cancer Center

June 29

Why isn’t HPV-driven cervical cancer a poster child for immunotherapy?

  • Douglas Hanahan, PhD
    DOUGLAS HANAHAN, PHD

    EPFL

JUNE 26

Pathways of Progression in Pancreatic Cancer

  • David Tuveson, MD, PhD
    DAVID TUVESON, MD, PHD

    Cold Spring Harbor Laboratory

June 25

Measuring and predicting cancer evolution using genomic data

  • Andrea Sottoriva, PhD, MSc
    ANDREA SOTTORIVA, PHD, MSC

    The Institute of Cancer Research

June 23

Mechanistic approach to the challenges of immunotherapy: resistance and inflammatory side effects

  • Kai Wucherpfennig, MD, PhD
    KAI WUCHERPFENNIG, MD, PHD

    Dana-Farber Cancer Institute

June 22

Deciphering the immuno-genomic landscape in melanoma

  • Yardena Samuels, PhD
    YARDENA SAMUELS, PHD

    The Weizmann Institute of Science

June 19

Finding Drivers of Resistance in Cancer

  • Gad Getz, PhD
    GAD GETZ, PHD

    Broad Institute

June 18

Multiscale image and omic view of progression in metastatic breast cancer

  • Joe Gray, PhD
    JOE GRAY, PHD

    OHSU Knight Cancer Institute

June 16

Breast Cancer Evolution Through the Lens of Single Cell Genomics

  • Nicholas Navin, PhD
    NICHOLAS NAVIN, PHD

    MD Anderson Cancer Center

June 15

New Strategies to Cure Lymphoid Neoplasms

HOST: Andrew LANE

  • David Weinstock, MD
    DAVID WEINSTOCK, MD

    Dana-Farber Cancer Institute

June 12

Genomic stratification of breast cancer reveals distinct tumor ecosystems

  • Carlos Caldas, MD, FMedSci
    CARLOS CALDAS, MD, FMEDSCI

    Cancer Research UK Cambridge Institute

June 11

Tracking Cancer Evolution, Metastases and Immune Escape: 5 Years of TRACERx

  • Charles Swanton,  FRS, FMedSci, FRCP
    CHARLES SWANTON, FRS, FMEDSCI, FRCP

    The Francis Crick Institute

June 9

MUTATIONS THAT DISRUPT HISTONE OCTAMER INTEGRITY AS CANCER DRIVERS

  • JONATHAN LICHT, MD
    JONATHAN LICHT, MD

    The University of Florida Health Cancer Center

June 8

Circulating Tumor Cells: A window into metastasis

  • Daniel Haber, MD, PhD
    DANIEL HABER, MD, PHD

    Mass General Cancer Center

June 5

Tumor suppressor functions of BRCA1 and BRCA2 at stalled replication forks

  • Ralph Scully, MBBS, PhD
    RALPH SCULLY, MBBS, PHD

    Beth Israel Deaconess Medical Center

June 4

Inactivation of DNA repair and high dose Vitamin C boost cancer immunotherapy

  • Alberto Bardelli, PhD
    ALBERTO BARDELLI, PHD

    Candiolo Cancer Institute

JUNE 2

The contribution of Merkel cell polyomavirus to Merkel cell carcinoma

HOST: Samuel Ng     

  • James DeCaprio, MD
    JAMES DECAPRIO, MD

    Dana-Farber Cancer Institute

JUNE 1

Global Views of Development

  • Jay Shendure, MD, PhD
    JAY SHENDURE, MD, PHD

    University of Washington



Due to technical difficulties, the recording to this talk will not be available. we apologize for the inconvenience. 
    

MAY 29

Age against the machine: How aging disrupts the homeostasis of cancer

  • Ashani Weeraratna, PhD
    ASHANI WEERARATNA, PHD

    Johns Hopkins Bloomberg School of Public Health

MAY 28

Developmental Epigenetic Memory: Storage, Retrieval, and Timing

  • Ramesh Shivdasani, MD, PhD
    RAMESH SHIVDASANI, MD, PHD

    Dana-Farber Cancer Institute

MAY 26

Effects of Epithelial-Mesenchymal Polarization on Carcinoma Cell Biology

  • Robert Weinberg, PhD
    ROBERT WEINBERG, PHD

    Massachusetts Institute of Technology

MAY 25

MEMORIAL DAY, NO LECTURE

MAY 22

A Genomics Journey – From Landscapes to Cures in Pediatric Oncology

  • Kimberly Stegmaier, MD
    KIMBERLY STEGMAIER, MD

    Dana-Farber Cancer Institute

MAY 21

TALK 1- CRISPR Gene Body Scan – Merging Functional Genomics, Structural Biology, and Drug Discovery

TALK 2 - Deubiquitinase Inhibition as a Novel Cancer Therapeutic Approach

  • Chun-Wei David Chen, PhD
    CHUN-WEI DAVID CHEN, PHD

    City of Hope Comprehensive Cancer Center

  • SARA BUHRLAGE, PHD
    SARA BUHRLAGE, PHD

    Dana-Farber Cancer Institute

MAY 19

Molecular scale on up with Neighborhoods & Tensors

  • Garry Nolan, PhD
    GARRY NOLAN, PHD

    Stanford University School of Medicine

MAY 18

Age-Related Clonal Hematopoiesis in Macaques: A Platform to Model Therapeutic Interventions

  • Cynthia E Dunbar, MD
    CYNTHIA E DUNBAR, MD

    NIH/NHLBI

MAY 15

A single-cell-resolution molecular recorder enables high resolution tumor lineage tracing

  • Jonathan Weissman, PhD
    JONATHAN WEISSMAN, PHD

    HHMI/UCSF

MAY 14

How Epigenetic Mechanisms Reprogram the Immune System to Induce Lymphomagenesis

  • Ari Melnick, MD
    ARI MELNICK, MD

    Weill Cornell Medicine

MAY 12

CRISPR and Coronavirus

  • Jennifer Doudna, PhD
    JENNIFER DOUDNA, PHD

    University of California, Berkeley

MAY 11

RNA methylation in gene expression regulation

  • Chuan He, PhD
    CHUAN HE, PHD

    University of Chicago

MAY 8

WHAT WE CAN LEARN ABOUT THE MICROENVIRONMENT FROM TUMORS THAT DO OR DON’T METASTASIZE

  • Zena Werb, PhD
    ZENA WERB, PHD

    University of California, San Francisco

MAY 7

Atlases as roadmaps to understanding tumors

  • AVIV REGEV, PHD
    AVIV REGEV, PHD

    Broad Institute

MAY 5

Cell Therapy for the Treatment of T-ALL and T-NHL

  • John F. DiPersio MD, PhD
    JOHN F. DIPERSIO MD, PHD

    Washington University School of Medicine

MAY 4

Small Molecule Protein Degradation- the Hype versus Reality

  • Nathanael Gray, PhD
    NATHANAEL GRAY, PHD

    Dana-Farber Cancer Institute

MAY 1

Gasdermin E suppresses tumor growth by activating anti-tumor immunity

  • Judy Lieberman, MD, PhD
    JUDY LIEBERMAN, MD, PHD

    Boston Children's Hospital

APRIL 30

Metabolic gatekeepers in B-cell malignancies

  • Markus Müschen, MD, PhD
    MARKUS MÜSCHEN, MD, PHD

    City of Hope Comprehensive Cancer Center

APRIL 28

Targeting Chromatin Complexes in Cancer

  • Scott Armstrong, MD, PhD
    SCOTT ARMSTRONG, MD, PHD

    Dana-Farber Cancer Institute

APRIL 27

A Dynamic View of Tumor Ecosystem

  • Dana Pe’er, PHD
    DANA PE’ER, PHD

    Memorial Sloan Kettering Cancer Center

APRIL 24

Regulating the immune response to cancer

  • Nick Haining, BCh, BM
    NICK HAINING, BCH, BM

    Merck Oncology

APRIL 23

Cancer Prevention and Early Detection in the Precision Medicine Era

  • Timothy Rebbeck, PhD
    TIMOTHY REBBECK, PHD

    Dana-Farber Cancer Institute

APRIL 21

Relapse-fate arises early in the evolution of human AML and B-ALL

  • John Dick, PhD, FRS
    JOHN DICK, PHD, FRS

    University Health Network

APRIL 20

Computational Modeling of Tumor Immunity

  • Xiaole Shirley Liu, PhD
    XIAOLE SHIRLEY LIU, PHD

    Dana-Farber Cancer Institute

APRIL 17

The Origin of Complex Cancer Genomes 

  • David Pellman, MD
    DAVID PELLMAN, MD

    Dana-Farber Cancer Institute

APRIL 16

How Aneuploidy causes Tumorigenesis 

  • Angelika Amon, PhD
    ANGELIKA AMON, PHD

    Massachusetts Institute of Technology

APRIL 14

Molecular Dissection of Tumor Evolution

  • Tyler Jacks, PhD
    TYLER JACKS, PHD

    Koch Institute for Integrative Cancer Research

APRIL 13

Overcoming obstacles to response to checkpoint blockade immunotherapy

  • Jedd Wolchok, MD, PhD
    JEDD WOLCHOK, MD, PHD

    Memorial Sloan Kettering Cancer Center

APRIL 10

Deciphering and targeting clonal evolution in myeloid malignancies

  • Ross Levine, MD
    ROSS LEVINE, MD

    Memorial Sloan Kettering Cancer Center

APRIL 9

Towards personalized microRNA therapeutics in cancer

  • Frank Slack, PhD
    FRANK SLACK, PHD

    Beth Israel Deaconess Medical Center

APRIL 7

T cell genome engineering at the clinic

  • Carl June, MD
    CARL JUNE, MD

    University of Pennsylvania Perelman School of Medicine

APRIL 6

Phenotypic screening approaches to oncology therapeutic discovery

  • Todd Golub, MD
    TODD GOLUB, MD

    Broad Institute and Dana-Farber Cancer Institute

APRIL 3

Targeted protein degradation for cancer therapeutics

  • Benjamin Ebert, MD, PhD
    BENJAMIN EBERT, MD, PHD

    Dana-Farber Cancer Institute

APRIL 2

Addressing cancer clonal heterogeneity: Developing personalized cancer vaccines

  • Catherine Wu, MD
    CATHERINE WU, MD

    Dana-Farber Cancer Institute

MARCH 31

Cancer Genomes in 3-Dimensions

  • Bradley Bernstein, MD, PhD
    BRADLEY BERNSTEIN, MD, PHD

    Massachusetts General Hospital

MARCH 30

Understanding Metastasis

  • Joan Massague, PhD
    JOAN MASSAGUE, PHD

    Memorial Sloan Kettering Cancer Center

MARCH 27

Stem Cell Clonality and the Niche

  • Leonard Zon, MD
    LEONARD ZON, MD

    Boston Children's Hospital

MARCH 26

Remembrance of Things Past: Turning on Fetal Hemoglobin to Treat Hemoglobin Disorders

  • Stuart H. Orkin, MD
    STUART H. ORKIN, MD

    Dana-Farber Cancer Institute

MARCH 24

Does The Microbiome Promote Human Cancer?

  • Matthew L. Meyerson, MD, PhD
    MATTHEW L. MEYERSON, MD, PHD

    Dana-Farber Cancer Institute

MARCH 23

The von Hippel-Lindau Hereditary Cancer Syndrome: From Bedside to Bench to Bedside

  • William G. Kaelin, Jr., MD
    WILLIAM G. KAELIN, JR., MD

    Dana-Farber Cancer Institute