Past Seminars
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March 28
RESCHEDULED; Please join us for our next seminar on April 11th
March 14
The ROLES and RULES of DNA methylation in development and environmental adaptation
HOST: BALAJI VENKADAKRISHNAN
March 7
Defining new targets and strategies for immunotherapy of advanced prostate cancer
HOST: BALAJI VENKADAKRISHNAN
February 14
Precision Genomics and Tumor Biology
HOST: TBD
February 07
Colon Cancer Checks In When Bile Acids Check Out
HOST: BALAJI VENKADAKRISHNAN
January 24
Interactions among interferon, PDL1, and cancer
HOST: Balaji VENKADAKRISHNAN
HOME | JANUARY | FEBRUARY | MARCH | APRIL | MAY | JUNE | JULY | AUGUST | SEPTEMBER | OCTOBER | NOVEMBER | DECEMBER
December 20 & 27
*NO SEMINAR - HOLIDAY OBSERVANCE*
December 06
Spatially organized immune hubs in tumors
HOST: Judith Agudo
November 22 & 29
*NO SEMINARS - HOLIDAY OBSERVANCE*
November 15
Multiple myeloma: The role of normal and malignant biology in the pathogenesis and treatment of disease
HOST: Kristopher Sarosiek
November 08
Uncovering determinants of tumor composition and immunity by spatial functional genomics
HOST: Judy Lieberman
November 01
Stem cell niches aren't just for growth factors anymore
HOST: Ramesh Shivdasani
October 25
*NO SEMINAR*
October 18
Immunological Mechanisms of Epithelial Cancer Defense
HOST: Judy Lieberman
October 11
*NO SEMINAR - HOLIDAY OBSERVANCE*
October 4
Metabolic regulation of cell fate decisions
HOST: Alejandro Gutierrez
September 20 - No Talk
September 13
Mechanisms of response and resistance of tumors to radiation and immunotherapy
HOST: Kristopher Sarosiek
June 14
Big Data Approaches to Study Intercellular Signaling in Cancer Immunotherapy Resistance
HOST: Kai Wucherpfennig
*No Seminar June 07*
Please consider another virtual event that was sent to us, the 2022 Susan Swerling Lecture
*No Seminar on May 31 - Holiday Observance*
May 24
GD2 CART cell therapy for DIPG/ DMG
HOST: Kornelia Polyak
May 17
Intrinsic and extrinsic mechanisms of adaptation to therapy in head and neck cancer
HOST: Sandra McAllister
*No Seminars on April 26*
April 12
Improving immunotherapy efficacy through solving immune-related adverse events
HOST: Judith Agudo
April 5
Rational drug combinations for the treatment of cancer
HOST: Eric Fischer
March 29
NK cell function in peripheral tissues
HOST: Daniel Haber
March 22
Immune-mediated regulation of breast cancer metastatic outgrowth
HOST: Kornelia Polyak
*No Seminar on March 8*
March 1
Direct KRAS Inhibitors
HOST: Eric Fischer
February 15
HGAL – an Adaptor Protein Regulating Motility, B –cell Receptor Signaling and Lymphomagenesis
HOST: Kristopher Sarosiek
February 8
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer
HOST: Daniel Haber
February 1
Inactivation of DNA repair and high dose Vitamin C boost cancer immunotherapy
HOST: Kornelia Polyak
January 18
Replenishing the ends: Visualization of human telomerase holoenzyme by cryo-EM
HOST: Eric Fischer
HOME | JANUARY | FEBRUARY | MARCH | APRIL | MAY | JUNE | JULY | AUGUST | SEPTEMBER | OCTOBER | NOVEMBER | DECEMBER
December 21
Mutant p53 Gain-of-Function in Cancer
HOST: david fisher
December 14
The Lysosome in Nutrient Sensing and Cellular Growth Control
HOST: Eric Fischer
December 7
Asymmetric cell division and germline immortality
HOST: David Pellman
November 30
One Step Backwards, Two Steps Forward: Approaches to Improved Immunotherapies
HOST: David Weinstock
NOVEMBER 23
NO LECTURE
November 16
The discovery of context specific paralog dependence in cancer through combinatorial CRISPR screens
HOST: Kornelia Polyak
November 2
Mechanisms regulating tumor transition states
HOST: Judith Agudo
October 26
Tracking population heterogeneity and the emergence of chemoresistance with functionalized cell barcodes
HOST: Kornelia Polyak
October 19
Computational identification of cell states and ecotypes associated with outcomes in solid tumors
HOST: shirley liu
October 12
Designing and translating next-generation CAR T cells
HOST: judy lieberman
September 28
Vasculogenic Mimicry (VM) as a mechanism of resistance to anti-angiogenics
HOST: senthil muthuswamy
September 21
Studying the spatial distribution of immune environments in human cancer
HOST: Sahand Hormoz
September 14
Structural biology of chromatin transcription
HOST: david pellman
June 22
Unexpected RNA-dependence of BRCA1 Function
HOST: Ralph Scully
June 15
Multi-level studies to address cancer health disparities: from neighborhoods to omics
HOST: Timothy Rebbeck
June 8
The Palmitoylation Cycle as a Therapeutic Target in NRAS Mutant Cancers
HOST: Alejandro Gutierrez
May 18
RNA splicing in cancer: New mechanisms and therapeutic opportunities
HOST: Judy Lieberman
May 11
Frederick National Laboratory for Cancer Research—A Shared Biomedical National Resource
HOST: David Weinstock
April 15
Cellular lipid homeostasis: From lipid droplets to lipotoxicity in cancer
HOST: Eric Fischer
April 13
Tumoricidal macrophages in cancer
HOST: Judith Agudo
April 8
MYC drives small cell lung cancer (SCLC) subtype plasticity
HOST: Sandra McAllister
Wednesday, April 7 at 10am
TALK 1- Immunotherapeutic targeting of genetically altered genes in cancers
TALK 2- Why does the immune system need help in killing cancer?
HOST: KORNELIA POLYAK
the recording to this talk WILL NOT BE available.
we apologize for the inconvenience.
APRIL 6
NO LECTURE
April 1
Understanding responses to cancer therapy: the tissue is the issue, the scoop is in the poop, and you are what you eat
HOST: Sandra McAllister
March 30
Targeting heterogeneity in breast cancer
HOST: David Weinstock
March 25
Searching for genetic network and cancer vulnerability
HOST: Lee Zou
March 23
Targeting CDK4/6 in cancer: new insights and opportunities
HOST: Sandra McAllister
March 18
Feedback Loops Limiting Effective Breast Cancer Therapy
HOST: KORNELIA POLYAK
March 11
Hijacking the Ubiquitin System for Protein Degradation Therapeutics
HOST: Michael Eck
March 9
Residual tumor cells persisting through cytotoxic therapies: new perspectives on the biology & therapeutic targeting of “Minimal” Residual Disease
HOST: David Weinstock
March 4
Cell lineage defines therapy resistance in neuroblastoma
HOST: Alejandro Gutierrez
March 2
Altered systemic metabolism and pancreatic cancer: Early disease biology and detection
HOST: Timothy Rebbeck
February 25
Cancer cell plasticity in metastasis and therapy-resistance
HOST: Sandra McAllister
February 23
Chromatin accessibility -a new vulnerability in BRCA mutant cancers
HOST: Lee Zou
February 18
Tumor zonation and immune microenvironments in triple-negative breast cancer
HOST: Sandra McAllister
February 16
Molecular glues activate specific flavors of PP2A tumor suppressors
HOST: Dr. Alejandro Gutierrez
February 11
Analysis of tumor ecosystems by multiplexed imaging
HOST: Kornelia Polyak
February 9
Immune Archetypes in Cancer and COVID
HOST: Judith Agudo
January 28
Learning the mechanisms of programmed cell death to develop novel therapies for cancer
HOST: Kristopher Sarosiek
January 26
Modulation of cohesn-complex factors regulates IgH locus contraction and long-Range V(D)J recombination
HOST: Ralph Scully
January 21
Dissecting the role of amino acid availability in controlling transcription and translation
HOST: Alejandro Gutierrez
January 19
Somatic mutations in normal tissues
HOST: Ralph Scully
January 14
Getting old stinks: how age related stromal changes drive tumor progression
HOST: Sandra McAllister
January 12
Transcriptional Phosphatase PP2A is a Central Regulator of Gene and Enhancer Activity
HOST: Alejandro Gutierrez
January 5
Agonist CD40 cancer immunotherapy – going beyond checkpoint blockade
HOST: Sandra McAllister
December 22-31
NO LECTURES
December 17
In the light of Evolution: Why do we get more cancers in old age?
HOST: Sandra McAllister
December 10
Insights gained from investigating the junk DNA of tumor epigenomes
HOST: Steve Balk
December 8
Cancer genes beyond chromosomes
HOST: Rani George
December 3
Skin Stem Cells: Coping With Stress
HOST: David Fischer
December 1
ALK inhibition in Neuroblastoma: From Discovery to Phase 3
HOST: Kristopher Sarosiek
November 24
Genetics and Genomics in Addressing High-Risk/Triple Negative Breast Cancer with African Ancestry
HOST: Eva Guinan
November 19
p53 and Mdm2: Masters of Life and of Death
HOST: Dipanjan Chowdhury
November 17
Linking Metabolism to Epigenetics: the Cancer Connection
HOST: Marcia Haigis
November 12
Biomarker screening algorithms for improved early detection of cancer
HOST: Rafael Irizarry
November 10
Unmasking the role of ubiquitin in regulating chromatin modifications
HOST: Wade Harper
November 5
TIME and Age: The impact of Age on the breast cancer Tumor Immune MicroEnvironment and therapeutic response
HOST: KORNELIA POLYAK
October 29
The QuEST for an effective immunotherapy for Prostate Cancer
HOST: Steve Balk
October 27
Exploitable changes in the BCL-2 network during tumor evolution
HOST: Kristopher Sarosiek
October 22
Uncovering new targets of the LKB1/STK11 tumor suppressor in lung cancer
HOST: Brendan Manning
October 20
Reprogramming T Cells with CRISPR
HOST: Xiaole Shirley Liu
October 15
BEACON TOWERS OF THE GREAT WALL: NEW NUCLEOTIDE-SENSING MEMBRANE PROTEINS AND THE INFLAMMATORY MICROENVIRONMENT
HOST: Judy Lieberman
OCTOBER 13
NO LECTURE
October 8
Enabling the robust characterization of spatial gene expression architecture in tissue sections at increased resolution using Bayesian modeling
HOST: Rafael Irizarry
October 6
LAP and LANDO: Non-canonical functions of autophagy proteins in anti-cancer immunity and Alzheimer's Disease
HOST: Kristopher Sarosiek
October 1
New Mechanisms for Old Cancer Drugs
HOST: DAVID WEINSTOCK
September 8
Polymerase Theta Inhibitor Overcomes PARP Inhibitor Resistance
HOST: Ralph SCULLY
