Past Seminars

December 13

Leveraging Drug Resistance Studies to Elucidate Breast Cancer Biology and Develop Better Therapies

HOST: Sara Tolaney                                     

December 06

Spatially organized immune hubs in tumors

HOST: Judith Agudo                                    

November 15

Multiple myeloma: The role of normal and malignant biology in the pathogenesis and treatment of disease

HOST: Kristopher Sarosiek                                      

November 08

Uncovering determinants of tumor composition and immunity by spatial functional genomics

HOST: Judy Lieberman                                    

November 01

Stem cell niches aren't just for growth factors anymore

HOST: Ramesh Shivdasani                                    

October 18

Immunological Mechanisms of Epithelial Cancer Defense

HOST: Judy Lieberman                                    

October 4

Metabolic regulation of cell fate decisions

HOST: Alejandro Gutierrez                                    

September 27

Somatic evolution of triple negative breast cancer

HOST: Kenneth Kehl                                     

September 13

Mechanisms of response and resistance of tumors to radiation and immunotherapy

HOST: Kristopher Sarosiek                                    

June 28

Lifting the Lid on Loop Extrusion

HOST: David Pellman

June 21 

Telomere shortening: Why and How?"

HOST: Ralph Scully

June 14

Big Data Approaches to Study Intercellular Signaling in Cancer Immunotherapy Resistance

HOST: Kai Wucherpfennig

May 24

GD2 CART cell therapy for DIPG/ DMG

HOST: Kornelia Polyak

May 17

Intrinsic and extrinsic mechanisms of adaptation to therapy in head and neck cancer

HOST: Sandra McAllister

May 10

Hyperactive dendritic cells and the control of anti-tumor immunity

HOST: Judy Lieberman

May 3

Reciprocal interplay between tissue tension and anti-tumor immunity

HOST: Kornelia Polyak

April 19 

CD8 T cell differentiation and fate choice in cancer and autoimmunity

HOST: Kai Wucherpfennig

April 12

Improving immunotherapy efficacy through solving immune-related adverse events

HOST: Judith Agudo

April 5

Rational drug combinations for the treatment of cancer

HOST: Eric Fischer

March 29

NK cell function in peripheral tissues

HOST: Daniel Haber

March 22

Immune-mediated regulation of breast cancer metastatic outgrowth

HOST: Kornelia Polyak

March 15

Single-cell biophysical approaches for cancer research

HOST: David Weinstock

March 1

Direct KRAS Inhibitors

HOST: Eric Fischer

February 22 

Identification of Redox and Druggable Vulnerabilities in Cancer

HOST: Lee Zou

February 15

HGAL – an Adaptor Protein Regulating Motility, B –cell Receptor Signaling and Lymphomagenesis

HOST: Kristopher Sarosiek

February 8

In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer

HOST: Daniel Haber

February 1

Inactivation of DNA repair and high dose Vitamin C boost cancer immunotherapy

HOST: Kornelia Polyak

January 25

Understanding and Targeting Altered RNA Splicing in Cancer

HOST: David Weinstock

January 18

Replenishing the ends: Visualization of human telomerase holoenzyme by cryo-EM

HOST: Eric Fischer

January 11

Designing Biology for Therapeutic Discovery

HOST: David Weinstock

December 21

Mutant p53 Gain-of-Function in Cancer

HOST: david fisher

December 14

The Lysosome in Nutrient Sensing and Cellular Growth Control

HOST: Eric Fischer

December 7

Asymmetric cell division and germline immortality

HOST: David Pellman

November 30

One Step Backwards, Two Steps Forward: Approaches to Improved Immunotherapies

HOST: David Weinstock

November 16

The discovery of context specific paralog dependence in cancer through combinatorial CRISPR screens

HOST: Kornelia Polyak

November 9

Post-transcriptional mechanisms in chemosurviving, quiescent cancer cells

HOST: judy Lieberman

the recording to this talk WILL NOT BE available.
we apologize for the inconvenience. 

November 2

Mechanisms regulating tumor transition states

HOST: Judith Agudo

October 26

Tracking population heterogeneity and the emergence of chemoresistance with functionalized cell barcodes

HOST: Kornelia Polyak

October 19

Computational identification of cell states and ecotypes associated with outcomes in solid tumors

HOST: shirley liu

October 12

Designing and translating next-generation CAR T cells

HOST: judy lieberman

October 5

SUMO signaling in genome stability maintenance

HOST: dipanjan chowdhury

the recording to this talk WILL NOT BE available.
we apologize for the inconvenience. 

September 28

Vasculogenic Mimicry (VM) as a mechanism of resistance to anti-angiogenics

HOST: senthil muthuswamy

September 21

Studying the spatial distribution of immune environments in human cancer

HOST: Sahand Hormoz

September 14

Structural biology of chromatin transcription

HOST: david pellman

June 22

Unexpected RNA-dependence of BRCA1 Function

HOST: Ralph Scully    

June 15

Multi-level studies to address cancer health disparities: from neighborhoods to omics

HOST: Timothy Rebbeck    

CLICK TO WATCH THE RECORDED TALK

June 8

The Palmitoylation Cycle as a Therapeutic Target in NRAS Mutant Cancers

HOST: Alejandro Gutierrez     

June 1 

Expanding the scope of DNA repair factors- novel roles and applications

HOST: Ralph Scully    

the recording to this talk WILL NOT BE available.
we apologize for the inconvenience. 

May 25

Tumorigenesis in the setting of DNA repair deficiencies

HOST: Ralph Scully    

the recording to this talk WILL NOT BE available.
we apologize for the inconvenience. 

May 18

RNA splicing in cancer: New mechanisms and therapeutic opportunities

HOST: Judy Lieberman    

May 11

Frederick National Laboratory for Cancer Research—A Shared Biomedical National Resource

HOST: David Weinstock    

May 4

Elucidating and Targeting Mechanisms of Single Cancer Cell State Maintenance

HOST: Judy Lieberman    

the recording to this talk WILL NOT BE available.
we apologize for the inconvenience. 

April 27 

Innate immune sensing through the cGAS-STING pathway

HOST: David Pellman   

the recording to this talk WILL NOT BE available.
we apologize for the inconvenience. 

April 20

Integration of Targeted Therapy and Immunotherapy: Mechanistic Insights and Clinical Implications

HOST: Kornelia Polyak   

the recording to this talk WILL NOT BE available.
we apologize for the inconvenience. 

April 15

Cellular lipid homeostasis: From lipid droplets to lipotoxicity in cancer

HOST: Eric Fischer     

April 13

Tumoricidal macrophages in cancer

HOST: Judith Agudo    

April 8

MYC drives small cell lung cancer (SCLC) subtype plasticity

HOST: Sandra McAllister     

Wednesday, April 7 at 10am

TALK 1- Immunotherapeutic targeting of genetically altered genes in cancers
TALK 2- Why does the immune system need help in killing cancer?

HOST: KORNELIA POLYAK    

the recording to this talk WILL NOT BE available.
we apologize for the inconvenience. 

April 1

Understanding responses to cancer therapy: the tissue is the issue, the scoop is in the poop, and you are what you eat

HOST: Sandra McAllister    

March 30

Targeting heterogeneity in breast cancer

HOST: David Weinstock    

March 25

Searching for genetic network and cancer vulnerability

HOST: Lee Zou    

March 23

Targeting CDK4/6 in cancer: new insights and opportunities

HOST: Sandra McAllister    

March 18

Feedback Loops Limiting Effective Breast Cancer Therapy

HOST: KORNELIA POLYAK    

March 16

Charting the topography of normal and malignant differentiation with single cell multi-omics

HOST: Priscilla Brastianos    

the recording to this talk WILL NOT BE available.
we apologize for the inconvenience. 

March 11

Hijacking the Ubiquitin System for Protein Degradation Therapeutics

HOST: Michael Eck    

March 9

Residual tumor cells persisting through cytotoxic therapies: new perspectives on the biology & therapeutic targeting of “Minimal” Residual Disease

HOST: David Weinstock     

March 4

Cell lineage defines therapy resistance in neuroblastoma

HOST: Alejandro Gutierrez    

March 2

Altered systemic metabolism and pancreatic cancer: Early disease biology and detection

HOST: Timothy Rebbeck    

February 25

Cancer cell plasticity in metastasis and therapy-resistance

HOST: Sandra McAllister    

February 23

Chromatin accessibility -a new vulnerability in BRCA mutant cancers

HOST: Lee Zou        

February 18

Tumor zonation and immune microenvironments in triple-negative breast cancer

HOST: Sandra McAllister    

February 16

Molecular glues activate specific flavors of PP2A tumor suppressors

HOST: Dr. Alejandro Gutierrez     

February 11

Analysis of tumor ecosystems by multiplexed imaging

HOST: Kornelia Polyak    

February 9

Immune Archetypes in Cancer and COVID

HOST: Judith Agudo    

February 4

The evolution of DNA methylation abnormalities during the initiation and progression of human cancers

HOST: David Fisher    

the recording to this talk WILL NOT BE available.
we apologize for the inconvenience. 

February 2

Protecting the genome by homologous recombination: role of the BRCA2 tumor suppressor

HOST: Lee Zou    

the recording to this talk WILL NOT BE available.
we apologize for the inconvenience. 

January 28

Learning the mechanisms of programmed cell death to develop novel therapies for cancer

HOST: Kristopher Sarosiek    

January 26

Modulation of cohesn-complex factors regulates IgH locus contraction and long-Range V(D)J recombination 

HOST: Ralph Scully    

January 21

Dissecting the role of amino acid availability in controlling transcription and translation

HOST: Alejandro Gutierrez     

January 19

Somatic mutations in normal tissues

HOST: Ralph Scully    

January 14

Getting old stinks: how age related stromal changes drive tumor progression

HOST: Sandra McAllister    

January 12

Transcriptional Phosphatase PP2A is a Central Regulator of Gene and Enhancer Activity

HOST: Alejandro Gutierrez    

January 7

Early Detection of Cancer using Machine Learning Analyses of Cell-Free DNA Fragmentation

HOST: Kornelia Polyak   

the recording to this talk WILL NOT BE available.
we apologize for the inconvenience. 

January 5

Agonist CD40 cancer immunotherapy – going beyond checkpoint blockade

HOST: Sandra McAllister    

December 17

In the light of Evolution: Why do we get more cancers in old age?

HOST: Sandra McAllister     

December 15

Insights into RAS/MAP kinase pathway regulation and pharmacology from cryo-EM structures of BRAF/MEK/14-3-3 complexes

HOST: David Weinstock    

the recording to this talk WILL NOT BE available.
we apologize for the inconvenience.     

December 10

Insights gained from investigating the junk DNA of tumor epigenomes

HOST: Steve Balk    

December 8

Cancer genes beyond chromosomes

HOST: Rani George    

December 3

Skin Stem Cells: Coping With Stress

HOST: David Fischer    

December 1

ALK inhibition in Neuroblastoma: From Discovery to Phase 3

HOST: Kristopher Sarosiek     

November 24

Genetics and Genomics in Addressing High-Risk/Triple Negative Breast Cancer with African Ancestry

HOST: Eva Guinan  

November 19

p53 and Mdm2: Masters of Life and of Death

HOST: Dipanjan Chowdhury      

November 17

Linking Metabolism to Epigenetics: the Cancer Connection

HOST: Marcia Haigis     

November 12

Biomarker screening algorithms for improved early detection of cancer

HOST: Rafael Irizarry     

November 10

Unmasking the role of ubiquitin in regulating chromatin modifications

HOST: Wade Harper  

November 5

TIME and Age: The impact of Age on the breast cancer Tumor Immune MicroEnvironment and therapeutic response

HOST: KORNELIA POLYAK     

November 3

Chemical Biology of Drug Resistance

HOST: Wade Harper     

the recording to this talk WILL NOT BE available.
we apologize for the inconvenience.     

October 29

The QuEST for an effective immunotherapy for Prostate Cancer

HOST: Steve Balk   

October 27

Exploitable changes in the BCL-2 network during tumor evolution

HOST: Kristopher Sarosiek    

October 22

Uncovering new targets of the LKB1/STK11 tumor suppressor in lung cancer

HOST: Brendan Manning     

October 20

Reprogramming T Cells with CRISPR

HOST: Xiaole Shirley Liu     

October 15

BEACON TOWERS OF THE GREAT WALL: NEW NUCLEOTIDE-SENSING MEMBRANE PROTEINS AND THE INFLAMMATORY MICROENVIRONMENT

HOST: Judy Lieberman      

October 8

Enabling the robust characterization of spatial gene expression architecture in tissue sections at increased resolution using Bayesian modeling

HOST: Rafael Irizarry     

October 6

LAP and LANDO: Non-canonical functions of autophagy proteins in anti-cancer immunity and Alzheimer's Disease

HOST: Kristopher Sarosiek     

October 1

New Mechanisms for Old Cancer Drugs

HOST: DAVID WEINSTOCK      

September 29

Oncogenic Pathways in Biliary Tract Cancer

HOST: Daniel Haber     

the recording to this talk WILL NOT BE available.
we apologize for the inconvenience.     

September 24

Cardio-Oncology: Cardiovascular Sequelae of Cancer Immunotherapies – From Bench to Bedside

HOST: Kristopher Sarosiek      

September 22

The yin and yang of an inflamed tumor microenvironment: Is there a relationship between lymphangiogenesis, metastasis, and immune priming

HOST: Kornelia Polyak     

the recording to this talk WILL NOT BE available.
we apologize for the inconvenience.     

September 17

Organoids to model human disease

HOST: Alejandro Gutierrez     

September 15

The double-edged sword of cellular senescence

HOST: Marcia Haigis     

September 10

Focal radiotherapy to convert the tumor into an in situ vaccine

HOST: Kristopher Sarosiek       

September 8

Polymerase Theta Inhibitor Overcomes PARP Inhibitor Resistance

HOST: Ralph SCULLY

September 3

Hypoxia, Metabolism, and Tumor Progression

HOST: Marcia Haigis 

September 1

Monitoring with Data During the COVID-19 Pandemic

HOST: David Weinstock     

August 27

Dissemination and metastatic dormancy of early evolved mammary cancer cells

HOST: Judith Agudo     

the recording to this talk IS NO LONGER available.
we apologize for the inconvenience.     

August 25

Poetry in motion: Increased chromosomal mobility after DNA damage

HOST: David Weinstock    

August 20

Unanticipated vulnerabilities of chemoresistant triple-negative breast cancer

HOST: Daniel Haber     

August 18

Sequential Bayesian Designs for Rapid Learning in COVID-19 Clinical Trials 

HOST: Rafael Irizarry     

August 13

Ubiquitin-dependent signaling in development and disease

HOST: Eric Fischer      

August 11

Relating single cell function to tissue structure in human health and disease using multiplexed ion beam imaging (MIBI)

HOST: Kornelia Polyak     

August 6

Synthetic Lethality of Wnt Pathway Activation and Asparaginase for Cancer Therapy

HOST: Sahand Hormoz    

August 4

Identifying therapeutic resistance mechanisms in cancer with single-cell data and machine learning

HOST: Aedin Culhane      

July 30

Transposable elements in cancer

HOST: David Pellman      

July 28

PD-1 blockade in cancer therapy: mechanism-based biomarkers and new frontiers

HOST: Kornelia Polyak    

July 23

Regulation of disseminated tumor cell dormancy in brain by the perivascular niche

HOST: Judith Agudo     

July 21

Targeting undruggable RAS for cancer treatment

HOST: Senthil Muthuswamy     

July 16

Transcription of the genome: mechanisms and regulatory strategies

HOST: Eric Fischer    

July 14

MIN-CIN’g the Genome: Microsatellite Instability drives Chromosome Instability 

HOST: David Pellman     

July 9

Transcription factor cross-talk in Estrogen Receptor positive breast cancer

HOST: KORNELIA Polyak    

July 7

Ubiquitin and autophagy networks in health and disease

HOST: Eric Fischer    

July 2

If you want to know how to treat cancer, ask the mitochondria

HOST: David Weinstock

June 30

TALK 1: Biology and therapeutic targeting of cohesin mutations in myeloid malignancies

TALK 2: Oncogenic mechanisms and therapeutic targeting of 2-hydroxyglutarate metabolism

June 29

Why isn’t HPV-driven cervical cancer a poster child for immunotherapy?

JUNE 26

Pathways of Progression in Pancreatic Cancer

June 25

Measuring and predicting cancer evolution using genomic data

June 23

Mechanistic approach to the challenges of immunotherapy: resistance and inflammatory side effects

June 22

Deciphering the immuno-genomic landscape in melanoma

June 19

Finding Drivers of Resistance in Cancer

June 18

Multiscale image and omic view of progression in metastatic breast cancer

June 16

Breast Cancer Evolution Through the Lens of Single Cell Genomics

June 15

New Strategies to Cure Lymphoid Neoplasms

HOST: Andrew LANE

June 12

Genomic stratification of breast cancer reveals distinct tumor ecosystems

June 11

Tracking Cancer Evolution, Metastases and Immune Escape: 5 Years of TRACERx

June 9

MUTATIONS THAT DISRUPT HISTONE OCTAMER INTEGRITY AS CANCER DRIVERS

June 8

Circulating Tumor Cells: A window into metastasis

June 5

Tumor suppressor functions of BRCA1 and BRCA2 at stalled replication forks

June 4

Inactivation of DNA repair and high dose Vitamin C boost cancer immunotherapy

JUNE 2

The contribution of Merkel cell polyomavirus to Merkel cell carcinoma

HOST: Samuel Ng     

JUNE 1

Global Views of Development

Due to technical difficulties, the recording to this talk will not be available. we apologize for the inconvenience.     

MAY 29

Age against the machine: How aging disrupts the homeostasis of cancer

MAY 28

Developmental Epigenetic Memory: Storage, Retrieval, and Timing

MAY 26

Effects of Epithelial-Mesenchymal Polarization on Carcinoma Cell Biology

MAY 22

A Genomics Journey – From Landscapes to Cures in Pediatric Oncology

MAY 21

TALK 1- CRISPR Gene Body Scan – Merging Functional Genomics, Structural Biology, and Drug Discovery

TALK 2 - Deubiquitinase Inhibition as a Novel Cancer Therapeutic Approach

MAY 19

Molecular scale on up with Neighborhoods & Tensors

MAY 18

Age-Related Clonal Hematopoiesis in Macaques: A Platform to Model Therapeutic Interventions

MAY 15

A single-cell-resolution molecular recorder enables high resolution tumor lineage tracing

MAY 14

How Epigenetic Mechanisms Reprogram the Immune System to Induce Lymphomagenesis

MAY 12

CRISPR and Coronavirus

MAY 11

RNA methylation in gene expression regulation

MAY 8

WHAT WE CAN LEARN ABOUT THE MICROENVIRONMENT FROM TUMORS THAT DO OR DON’T METASTASIZE

MAY 7

Atlases as roadmaps to understanding tumors

MAY 5

Cell Therapy for the Treatment of T-ALL and T-NHL

MAY 4

Small Molecule Protein Degradation- the Hype versus Reality

MAY 1

Gasdermin E suppresses tumor growth by activating anti-tumor immunity

APRIL 30

Metabolic gatekeepers in B-cell malignancies

APRIL 28

Targeting Chromatin Complexes in Cancer

APRIL 27

A Dynamic View of Tumor Ecosystem

APRIL 24

Regulating the immune response to cancer

APRIL 23

Cancer Prevention and Early Detection in the Precision Medicine Era

APRIL 21

Relapse-fate arises early in the evolution of human AML and B-ALL

APRIL 20

Computational Modeling of Tumor Immunity

APRIL 17

The Origin of Complex Cancer Genomes 

APRIL 16

How Aneuploidy causes Tumorigenesis 

APRIL 14

Molecular Dissection of Tumor Evolution

APRIL 13

Overcoming obstacles to response to checkpoint blockade immunotherapy

APRIL 10

Deciphering and targeting clonal evolution in myeloid malignancies

APRIL 9

Towards personalized microRNA therapeutics in cancer

APRIL 7

T cell genome engineering at the clinic

APRIL 6

Phenotypic screening approaches to oncology therapeutic discovery

APRIL 3

Targeted protein degradation for cancer therapeutics

APRIL 2

Addressing cancer clonal heterogeneity: Developing personalized cancer vaccines

MARCH 31

Cancer Genomes in 3-Dimensions

MARCH 30

Understanding Metastasis

MARCH 27

Stem Cell Clonality and the Niche

MARCH 26

Remembrance of Things Past: Turning on Fetal Hemoglobin to Treat Hemoglobin Disorders

MARCH 24

Does The Microbiome Promote Human Cancer?

MARCH 23

The von Hippel-Lindau Hereditary Cancer Syndrome: From Bedside to Bench to Bedside