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  • Tolaney SM, Jiang Z, Zhang Q, Barroso-Sousa R, Park YH, Rimawi MF, Saura C, Schneeweiss A, Toi M, Chae YS, Kemal Y, Chaudhari M, Şendur MAN, Yamashita T, Casalnuovo M, Danso MA, Liu J, Shetty J, Herbolsheimer P, Loibl S, . Trastuzumab Deruxtecan plus Pertuzumab for HER2-Positive Metastatic Breast Cancer. N Engl J Med 2025. PubMed
  • Tesch ME, Zheng Y, Guzman-Arocho YD, Collins LC, Heng YJJ, Tayob N, Rosenberg SM, Ruddy KJ, Tamimi RM, Schapira L, Peppercorn J, Borges V, Come SE, Snow C, Winer E, Mittendorf EA, Partridge AH. Association of tumor-infiltrating lymphocyte subtypes with clinical characteristics and prognosis in young women with hormone receptor-positive breast cancer. Clin Cancer Res 2025. PubMed
  • Zhang Y, Bhosle A, Bae S, Eckenrode K, Huang X, Tang J, Lavrentovich D, Awad L, Hua J, Wang Y, Morgan XC, Li B, Krueger A, Garrett WS, Franzosa EA, Huttenhower C. Predicting functions of uncharacterized gene products from microbial communities. Nat Biotechnol 2025. PubMed
  • Nader-Marta G, Chu X, Mukhopadhyay S, Abramson VG, Brufsky A, Stringer-Reasor EM, Dent SF, Traina TA, Carey LA, Rimawi MF, Specht JM, Miller KD, Santa-Maria CA, Dasgupta T, Kurt BB, DeMeo M, Krop IE, Tung NM, Schnitt SJ, Tayob N, Mayer EL. Prognostic value of visually and computationally-assessed tumor-infiltrating lymphocytes in early-stage triple-negative breast cancer (TBCRC-030). Journal of the National Cancer Institute 2025. PubMed
  • Wang Z, Li Z, Högström J, Inuzuka H, Jing R, Yan P, Hou T, Qi Y, Huang D, Wang J, Wu T, Shi X, Liu B, Muranen T, Zhang D, Wei W. Dual membrane receptor degradation via folate receptor targeting chimera. Nat Commun 2025; 16:8804. PubMed
  • Zhou C, Zhang M, Murray J, Paulo J, Gygi S, Shao S, Whitman M, Keller T. GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling. Science 2025; 390:eads8728. PubMed
  • Manz CR, Nava-Coulter B, Voligny E, Gundersen DA, Wright AA. Correctional Health and Oncologist Perspectives on Strategies to Improve Cancer Care in US Prisons: A Qualitative Study. JAMA Netw Open 2025; 8:e2537640. PubMed
  • Manz CR, Nava-Coulter B, Voligny E, Gundersen DA, Wright AA. Barriers and Facilitators to Delivering Cancer Care in US Prisons. JAMA Netw Open 2025; 8:e2537646. PubMed
  • Park JC, Curti B, Butler M, Wehrenberg-Klee E, Elassal J, Tighe R, Battula S, Iodice G, Kaufman HL, Kirkwood JM. Interleukin-12 anchored drug conjugate (tolododekin alfa) in patients with advanced solid tumors: first-in-human Phase 1 trial. Nat Commun 2025; 16:8567. PubMed
  • Zhao J, Lin SY, Attias R, Mathews L, Engel C, Larghero G, Vremenko D, Kao TW, Lee TH, Wang YH, Tsai CC, Marostica E, Lo YC, Meredith D, Ligon KL, Arnaout O, Roetzer-Pejrimovsky T, Lin SC, Shih NN, Chaisuriya N, Cook DJ, Chiang JH, Liu CJ, Woehrer A, Golden JA, Nasrallah MP, Yu KH. Uncertainty-aware ensemble of foundation models differentiates glioblastoma from its mimics. Nat Commun 2025; 16:8341. PubMed
  • Yapp C, Nirmal AJ, Zhou F, Wong AYH, Tefft JB, Lu YD, Shang Z, Maliga Z, Llopis PM, Murphy GF, Lian CG, Danuser G, Santagata S, Sorger PK. Highly multiplexed 3D profiling of cell states and immune niches in human tumors. Nat Methods 2025. PubMed
  • Knudsen NH, Escobar G, Korell F, Kienka T, Nobrega C, Anderson S, Cheng AY, Zschummel M, Armstrong A, Bouffard A, Kann MC, Goncalves S, Pope HW, Pezeshki M, Rojas A, Suermondt JSMT, Phillips M, Berger TR, Park S, Salas-Benito D, Darnell EP, Birocchi F, Leick MB, Larson RC, Doench JG, Sen D, Yates KB, Manguso RT, Maus MV. In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma. Nature 2025. PubMed
  • Steinicke TL, Benfatto S, Capilla-Guerra MR, Monteleone AB, Young JH, Shankar S, Michaels PD, Tsai HK, Good JD, Kreso A, van Galen P, Schliemann C, Chen EC, Griffin GK, Hovestadt V. Rapid epigenomic classification of acute leukemia. Nat Genet 2025. PubMed
  • Xiao H, Ordonez M, Fink EC, Covington TA, Woldemichael HB, Chen J, Jain MS, Rohatgi MH, Wei SM, Burger N, Sharif MA, Jan J, Wang Y, Petrocelli JJ, Blackmore K, Smythers AL, Zhang B, Gilbert M, Cheong H, Khetarpal SA, Smith A, Bogoslavski D, Lei Y, Vaites LP, McAllister FE, Van Bruggen N, Donovan KA, Huttlin EL, Mills EL, Fischer ES, Chouchani ET. Covariation MS uncovers a protein that controls cysteine catabolism. Nature 2025. PubMed
  • Mayerhofer C, Li D, Kristiansen T, Mayerhofer E, Sharda A, Schiroli G, Gustafsson K, He L, Mazzola M, Keyes S, Kiem A, Crompton E, Xu Y, Korm S, Dou Z, Vidoudez C, Miller PG, van Gastel N, Graubert TA, Scadden DT. OGFOD1 enables AML chemo- and nutrient stress resistance by regulating protein synthesis. Cell Metab 2025. PubMed
  • Liao G, Nakayama T, Zhu B, Lee IT, Yeung J, Yeo YY, Chang Y, Wang C, Liao SC, Nkosi D, Renteria A, Bravo DT, Overdevest JB, Yan CH, Zarabanda D, Gall PA, Dholakia SS, Borchard NA, Yang A, Kim D, Patel ZM, Hwang PH, Wagh D, Coller J, Phillips KM, Chang MT, Lechner M, Li Z, Yeh TH, Nolan G, Longhi MS, Boussiotis V, Barouch DH, Ma Q, Nayak JV, Jiang S. Multi-scaled transcriptomics of chronically inflamed nasal epithelium reveals immune-epithelial dynamics and tissue remodeling in nasal polyp formation. Immunity 2025. PubMed
  • Abou Haidar E, Prabhakar S, Geffrey AL, Mahamdeh M, Tomeh T, Breyne K, Roumieh E, Gurevich M, Soberman RJ, Wojtkiewicz GR, Chen JW, Han JS, Stemmer-Rachamimov A, Breakefield XO. AAV hamartin gene therapy in a stochastic, cerebral mouse model of tuberous sclerosis type 1. Mol Ther Methods Clin Dev 2025; 33:101556. PubMed
  • Savchuk S, Gentry KM, Wang W, Carleton E, Biagi-Junior CAO, Luthria K, Yalçın B, Ni L, Farnsworth HC, Davis RA, Drexler R, Melms JC, Liu Y, Acosta-Alvarez L, Hartmann GG, Pavarino EC, LaBelle J, Woo PJ, Toland AM, Qu F, Kim YS, Filbin MG, Krasnow MA, Ligon KL, Izar B, Sage J, Sabatini BL, Monje M, Venkatesh HS. Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis. Nature 2025. PubMed
  • Varghese JF, Fujiwara M, Ajay AK, Garo LP, Cannon A, Kadowaki-Saga R, Gabriely G, Pradella F, Ferrari B, Patel R, Dhuppar S, Cecere RR, Kolypetri P, Krishnan R, Saxena S, Healy B, Bose G, Weiner HL, Chitnis T, Murugaiyan G. Type I interferon limits central nervous system autoimmunity by modulating the microRNA-21-FOXO1 axis in pathogenic T helper 17 cells. Sci Transl Med 2025; 17:eadp5802. PubMed
  • Parsons HA, Messer C, Santos K, Weiss J, Merrell D, Danysh BP, Hughes ME, Kirkner GJ, Patel A, Hess J, Sendrick K, Stewart C, Grant E, Schlueter-Kuck K, Grinshpun A, Wagle N, Veeraraghavan J, Leone JP, Freedman RA, Metzger O, Schiff R, Winer EP, Tolaney SM, Rimawi M, Krop IE, Getz G, Lin NU. Detection of heterogeneous resistance mechanisms to tyrosine kinase inhibitors from cell-free DNA. Cell Genom 2025. PubMed
  • Salem S, Han T, Alchoueiry M, Mahmoud N, Bzeih W, Chami J, Khabibullin D, Mansour H, Tang Y, Ho TH, Ubellacker JM, Priolo C, Henske EP. Targeting FSP1 to induce ferroptosis in chromophobe renal cell carcinoma. Oncogene 2025. PubMed
  • Bourhis J, Licitra LF, Burtness B, Psyrri A, Haddad R, Harrington K, Cohen EEW, Tao Y, Tiscoski KA, Matitashvili A, Tahara M, Sukari A, Rutkowski T, Salas S, Nauwelaerts H, Scheerlinck R, Ha NT, Schroeder A, Rodriguez-Gutierrez A, Schoenfeld JD. Xevinapant or Placebo Plus Platinum-Based Chemoradiotherapy in Unresected Locally Advanced Squamous Cell Carcinoma of the Head and Neck (TrilynX): A Randomized, Phase III Study. J Clin Oncol 2025. PubMed
  • Khetan S, Carroll BS, Bulyk ML. Multiple overlapping binding sites determine transcription factor occupancy. Nature 2025. PubMed
  • Marin-Rodero M, Jayewickreme T, Benoist C, Mathis D. Seeding of visceral adipose tissue with perinatally generated regulatory T cells shapes the metabolic tenor in mice. Proc Natl Acad Sci U S A 2025; 122:e2518203122. PubMed
  • Straczkiewicz M, Keating NL, Schonholz SM, Matulonis UA, Horowitz N, Campos S, Onnela JP, Wright AA. Smartphone-Based Measures as Indicators of Functional Status in Patients With Advanced Cancer. JAMA Netw Open 2025; 8:e2532488. PubMed
  • Jang DM, Boxer K, Ha BH, Tkacik E, Levitz T, Rawson S, Metivier RJ, Schmoker A, Jeon H, Eck MJ. Cryo-EM structures of CRAF/MEK1/14-3-3 complexes in autoinhibited and open-monomer states reveal features of RAF regulation. Nat Commun 2025; 16:8150. PubMed
  • LaFleur MW, Milling LE, Prathima P, Li V, Lemmen AM, Streeter ISL, Heisig PKS, Derosia NM, Riffo E, Xu H, Nguyen TH, Kolengaden A, Markson SC, Doench JG, Sharpe AH. A STUB1-CHIC2 complex inhibits CD8 T cells to restrain tumor immunity. Nat Immunol 2025; 26:1476-1487. PubMed
  • Shah B, Hunkeler M, Bratt A, Yue H, Jaen Maisonet I, Fischer ES, Buhrlage SJ. Structural basis of VCP-VCPIP1-p47 ternary complex in Golgi maintenance. Nat Commun 2025; 16:8025. PubMed
  • Tavakolpour S, Nili A, Munaretto LA, Huang CK, Rakhshandehroo T, Kim Z, Knight AE, Farid AS, Alasharee MA, Allen H, Uslu S, Moravej H, Cong M, Berland L, Simkova E, Shahbazian H, Rowley JE, Mantri SR, Noe MH, Barrett CD, Ward A, Tsokos GC, Wei EX, Rashidian M. Antigen-Fc fusion therapy reduces severity of a model of pemphigus vulgaris without systemic immunosuppression. Sci Transl Med 2025; 17:eadk6484. PubMed
  • Mariani L, Liu X, Lee K, Gisselbrecht SS, Cole PA, Bulyk ML. DNA bendability regulates transcription factor binding to nucleosomes. Nat Struct Mol Biol 2025. PubMed
  • Hagihara Y, Zhang C, Zhang Y. Precise modulation of BRG1 levels reveals features of mSWI/SNF dosage sensitivity. Nat Genet 2025. PubMed
  • Kübler K, Nardone A, Anand S, Gurevich D, Gao J, Droog M, Hermida-Prado F, Akhshi T, Feiglin A, Feit AS, Cohen Feit G, Dackus G, Pun M, Kuang Y, Cha J, Miller M, Gregoricchio S, Lanfermeijer M, Cornelissen S, Gibson WJ, Paweletz CP, Van Allen EM, van Leeuwen FE, Nederlof PM, Nguyen QD, Mourits MJE, Radovich M, Leshchiner I, Stewart C, Matulonis UA, Zwart W, Maruvka YE, Getz G, Jeselsohn R. Tamoxifen induces PI3K activation in uterine cancer. Nat Genet 2025. PubMed
  • Słabicki M, Park J, Nowak RP, Roy Burman SS, Pellman J, Zou C, Razumkov H, Carreiro J, Rastogi S, Goldstein A, Nagiec MM, Donovan KA, Che J, Hunkeler M, Geng Q, Hsu CL, Lakshminarayan M, Shu C, Zon RL, Kozicka Z, Park PMC, Tsai JM, Yoon H, Jones LH, Sperling AS, Gray NS, Fischer ES, Ebert BL. Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation. Mol Cell 2025; 85:3184-3201.e14. PubMed
  • Ligibel JA, Ballman KV, McCall L, Goodwin PJ, Alfano CM, Bernstein V, Crane TE, Delahanty LM, Frank E, Hahn O, Hershman DL, Hopkins JO, Irwin M, Mayer EL, Minasian L, Nebeling L, Neuhouser ML, Paskett ED, Spears PA, Stearns V, Thomson CA, Weiss A, White J, Wadden TA, Winer EP, Hudis C, Partridge AH, Carey LA. Impact of a Weight Loss Intervention on 1-Year Weight Change in Women With Stage II/III Breast Cancer: Secondary Analysis of the Breast Cancer Weight Loss (BWEL) Trial. JAMA Oncol 2025. PubMed
  • Singh S, Gleason CE, Fang M, Laimon YN, Khivansara V, Xie S, Durmaz YT, Sarkar A, Ngo K, Savla V, Li Y, Abu-Remaileh M, Li X, Locquet MA, Tuladhar B, Odeh R, Hamkins-Indik F, He D, Membreno MW, Nosrati M, Gushwa NN, Leung SSF, Fraga-Walton B, Hernandez L, Baldomero MP, Lent BM, Spellmeyer D, Luna JF, Hoang D, Gritsenko Y, Chand M, DeMart MK, Metobo S, Bhatt C, Shapiro JA, Yang K, Dupper NJ, Bockus AT, Fang J, Bambal R, Cremin P, Doench JG, Aggen JB, Liu LF, Levin B, Wang EW, Vendrell I, Fischer R, Kessler B, Gokhale PC, Signoretti S, Spektor A, Kreatsoulas C, Evangelista M, Singh R, Earp DJ, Nijhawan D, Garcia PD, Oser MG. Targeting G1-S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors. Nature 2025. PubMed
  • Börcsök J, Gopaul D, Devesa-Serrano D, Mooser C, Jonsson N, Cagiada M, Stormoen DR, Ataya MN, Guercio BJ, Kaimakliotis HZ, Iyer G, Lindorff-Larsen K, Dyrskjøt L, Mouw KW, Szallasi Z, Sørensen CS. Quantitative functional profiling of ERCC2 mutations deciphers cisplatin sensitivity in bladder cancer. J Clin Invest 2025. PubMed
  • Vuille JA, Tanriover C, Antmen E, Micalizzi DS, Ebright RY, Animesh S, Morris R, Hajizadeh S, Nicholson ZJ, Russell HC, Zaniewski EF, Wittner BS, Wesley BK, Kwak JE, Grünewald J, Szalay RN, Fox DB, Yang M, Joung JK, Gulhan DC, Elia AEH, Haas W, Oh E, Maheswaran S, Haber DA. The E3 ligase HECTD4 regulates COX-2-dependent tumor progression and metastasis. Proc Natl Acad Sci U S A 2025; 122:e2425621122. PubMed
  • Maurer K, Weir JA, Nagler A, Haradhvala NJ, Bharadwaj H, Shapiro J, Alakwe S, Kumar V, Waller B, McDonough M, Dela Cruz J, Luna L, Lin E, Gong L, Gong Q, Borji M, Michaels PD, Laubach JP, Pinkus G, Getz G, Wu CJ, Chen F, Jacobson C. A clonally expanded nodal T-cell population diagnosed as T-cell lymphoma after CAR-T therapy. Nat Commun 2025; 16:7462. PubMed
  • Lightbody ED, Sklavenitis-Pistofidis R, Wu T, Tsuji J, Firer DT, Agius MP, Dutta AK, Barr H, Kim S, Alberge JB, Nersesian S, Coorens T, Haradhvala NJ, Su NK, Boehner CJ, Aranha MP, Rahmat M, Konishi Y, Hevenor L, Towle K, Horowitz E, Perry J, Davis M, Walsh KA, Cea-Curry CJ, Fleming G, Vinyard ME, Heilpern-Mallory D, El-Khoury H, Cowan A, Ready JE, Marinac CR, Getz G, Ghobrial IM. SWIFT-seq enables comprehensive single-cell transcriptomic profiling of circulating tumor cells in multiple myeloma and its precursors. Nat Cancer 2025. PubMed
  • Graziano VR, Porat J, Ah Kioon MD, Mejdrová I, Matz AJ, Lebedenko CG, Chai P, Pluvinage JV, Ricci-Azevedo R, Harrison AG, Wright SS, Wang X, Strine MS, Wang P, Wilson MR, Vanaja SK, Zhou B, Barrat FJ, Carell T, Flynn RA, Rathinam VA. RNA N-glycosylation enables immune evasion and homeostatic efferocytosis. Nature 2025. PubMed
  • El-Jawahri A, Traeger L, Reese JB, Dizon D, Bober SL, Greer JA, Vanderklish J, Horick N, Ufere N, Reynolds MJ, Rice J, Clay M, Newcomb R, DeFilipp Z, Chen YB, Temel JS. A multimodal sexual dysfunction intervention versus enhanced usual care for survivors of haematopoietic stem-cell transplantation: a single-centre, open-label, randomised clinical trial. Lancet Haematol 2025; 12:e611-e620. PubMed
  • Xie Y, Liu X, Yi L, Wang S, Lin Z, Zhao C, Chen S, Robison FM, George BM, Lebrilla CB, Flynn RA, Garcia BA. Development and application of GlycanDIA workflow for glycomic analysis. Nat Commun 2025; 16:7075. PubMed
  • Apfelbaum AA, Morin E, Sturm D, Ayoub G, DiGiacomo J, Bahadur S, Chandarana B, Power PC, Cusick MM, Novikov D, Prabhakar P, Jones RE, Vogelzang J, Bossi CC, Malinowski S, Woodward LM, Jones TA, Jeang J, Lamson SW, Collins J, Cai KY, Jones JS, Oh S, Jeon H, Wang J, Cameron A, Rechter P, De Leon A, Murugesan K, Montesion M, Albacker LA, Ramkissoon SH, van Tilburg CM, Hardin EC, Sievers P, Sahm F, Yeo KK, Rosenberg T, Chi SN, Wright KD, Hébert S, Peck S, Picca A, Larouche V, Renzi S, Buhrlage SJ, Bale TA, Smith AA, Touat M, Jabado N, Fischer ES, Eck MJ, Baird L, Witt O, Kleinman CL, Nguyen QD, Sheer D, Alexandrescu S, Jones DTW, Ligon KL, Bandopadhayay P. A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas. Nat Commun 2025; 16:7018. PubMed
  • Heavican-Foral TB, Korell F, Scarfò I, Wiggers CRM, B AT, Eisenbies Z, Powers F, Hegel J, Liu J, Kulp S, Silva H, Wu G, Letai A, Stegmaier K, Lohr JG, Weinstock DM, Maus MV, Knoechel B. Combining MCL-1 inhibition and CD37-directed chimeric antigen receptor T cells as an effective strategy to target T-cell lymphoma. Leukemia 2025. PubMed
  • Zhang H, Santana-Codina N, Yu Q, Poupault C, Campos C, Qin X, Sindoni N, Ciscar M, Padhye A, Kuljanin M, Wang J, Dorman MJ, Bross P, Aguirre AJ, Dougan SK, Sarosiek KA, Mancias JD. De novo pyrimidine biosynthesis inhibition synergizes with BCL-X targeting in pancreatic cancer. Nat Commun 2025; 16:6987. PubMed
  • Mout R, Jing R, Tanaka-Yano M, Egan ED, Eisenach H, Kononov MA, Windisch R, Najia MAT, Tompkins A, Hensch L, Bingham T, Gunage R, Zhao Y, Edman NI, Li C, Wang D, Schlaeger TM, Zon LI, North TE, Lendahl U, Rowe RG, Baker D, Blacklow SC, Daley GQ. Design of soluble Notch agonists that drive T cell development and boost immunity. Cell 2025. PubMed
  • Zammit NW, Vargas-Castillo A, Langston PK, Wang G, Zhou Y, Spiegelman BM, Benoist C, Mathis D. Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-γ-producing lymphocytes. Sci Immunol 2025; 10:eads0478. PubMed
  • Kim JJ, Walton SA, Mahadevan NR, Haradon J, Paoloni F, Paik PK, Chaft JE, Hsu R, Piha-Paul SA, Jänne PA, Barbie DA, Sholl LM, Dubois SG, Hanna GJ, Shapiro GI, French CA, Luo J. Molecular characterization of NUT carcinoma: a report from the NUT carcinoma registry. Clin Cancer Res 2025. PubMed
  • Dominici LS, Zheng Y, King TA, Wong J, Ruddy KJ, Tamimi RM, Peppercorn J, Schapira L, Borges V, Come S, Collins LC, Warner E, Partridge AH, Rosenberg SM. Long-Term Locoregional Outcomes in a Contemporary Cohort of Young Women With Breast Cancer. JAMA Surg 2025. PubMed
  • Konstantinopoulos PA, Kim JW, Freyer G, Lee JY, Gaba L, Grisham RN, Colombo N, Wu X, Sehouli J, Cruz F, Cibula D, Monk BJ, Nyvang GB, Friedlander M, Lorusso D, Van Nieuwenhuysen E, Malik R, Glasspool R, Marth C, Leary A, Cortés-Salgado A, Zamagni C, Marmé F, Sufliarsky J, Hinson P, Zuradelli M, Wang C, Su F, Paule I, Miller M, Matulonis UA, González-Martín A. Primary Analysis of EPIK-O/ENGOT-ov61: Alpelisib Plus Olaparib Versus Chemotherapy in Platinum-Resistant or Platinum-Refractory High-Grade Serous Ovarian Cancer Without Mutation. J Clin Oncol 2025. PubMed
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