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  • Martin TD, Choi MY, McBride JC, Elledge SJ. Changes in the transcriptome and synthetic lethal dependencies following mutant expression reveal profound tissue specificity. Proc Natl Acad Sci U S A 2026; 123:e2614664123. PubMed
  • Fathi AT, Perl AE, Fell GG, Jonas BA, Ragon BK, Mims AS, Borate U, Mannis GN, Quillen K, Stahl M, Aubrey BJ, Koller P, Artz AS, Al Malki MM, Stein AS, Marcucci G, Peters MLB, Graubert TA, Westervelt P, Amrein PC, Hock HR, Brunner AM, Hobbs G, Narayan R, Lee MH, Miller PG, Watson AL, Hao R, Marola AC, Lombardi-Story J, Dhaver S, Grunwald MR, Chen YB, Weinstock MJ, Matthews AH, McGovern I, Wood BL, Hourigan CS, Neuberg DS, El-Jawahri A, Aldoss I. Azacitidine-Venetoclax or Induction Chemotherapy for Acute Myeloid Leukemia. N Engl J Med 2026; 395:845-858. PubMed
  • Chu C, Zheng S, Mitchell N, Li Z, Zhang X, Wu X, Zhang T, Dang F, Michowski W, Kolodziejczyk A, Xu ML, Kotowski KW, Yang Z, Martinez-Alonso D, Paulo J, Sheng J, Kirby JA, Groezinger F, Zhou Y, He M, Ito Y, Gulvady AC, Cole MI, Foidart P, Nishida J, Ning X, Sharma S, Suski JM, Fassl A, Zhou Y, Geng Y, Wei W, Gygi SP, Polyak K, Wucherpfennig KW, Sicinski P. Cyclin E-CDK2 regulates cancer cell transcriptional program and response to immunotherapy through BRD4. Mol Cell 2026. PubMed
  • Karam J, Hoffman SE, Garza A, Gui D, Hoffman HI, Titchen BM, Tanaka Y, Pimenta E, Pappa T, Valderrabano L, Bi K, Gillani R, Brais L, Shannon E, Hornick JL, Park J, Chan J, Van Allen EM. Conserved neuronal-like and secretory programs define the spatial architecture of gastroenteropancreatic neuroendocrine tumors. J Clin Invest 2026. PubMed
  • Shah K, Anastasakou E, Sejour L, Guseva S, Rauchet C, Wert-Lamas L, Calandrelli R, Distel R, Zhong S, Vlachos I, Novina CD. Long non-coding RNA triplex-dependent regulation of melanoma gene networks. NAR Genom Bioinform 2026; 8:lqag067. PubMed
  • Cheng YC, Gu H, McDonald TO, Wu W, Tripathi S, Guarducci C, Russo D, Abravanel DL, Bailey M, Wang Y, Zhang Y, Pantazis Y, Levine H, Jeselsohn R, Katsoulakis MA, Michor F. PROFET predicts continuous gene expression dynamics from scRNA-seq data to elucidate heterogeneity of cancer treatment responses. Cell Syst 2026. PubMed
  • Shi P, Melillo B, McHenry MW, Camara CM, Yang K, Njomen E, Godes M, Pazyra-Murphy MF, Branch MR, Tesar B, Segal RA, Rubin LL, Cameron MD, Bird GH, Wales TE, Gygi SP, Cravatt BF, Walensky LD. An enantioselective covalent inhibitor of BAX confers cytoprotection in vivo. Nat Chem Biol 2026. PubMed
  • Panikkanvalappil SR, Maloney E, Ahn SW, Martin S, Marlin C, Bhagavatula SK, Jonas O. A spatially resolved implantable microdevice for multiplexed in situ screening of engineered cellular therapies in solid tumors. Sci Adv 2026; 12:eaee6195. PubMed
  • De Stefano F, Wu NF, Belfiori G, Roberts HJ, Ferrone C, Aleotti F, Allen JN, Balzano G, Blaszkowsky LS, Clark JW, De Cobelli F, Fagenholz PJ, Gasparini G, Harrison JM, Hong TS, Lester NA, Palumbo D, Pathak PS, Pecorelli N, Lena MS, Tang R, Tamburrino D, Weekes CD, Qadan M, Partelli S, Lillemoe KD, Ryan DP, Wo JY, Crippa S, Falconi M, Fernández-Del Castillo C. Neoadjuvant Chemotherapy With or Without Radiotherapy in Resected Pancreatic Ductal Adenocarcinoma. JAMA Surg 2026. PubMed
  • Caswell-Jin JL, Somerfield MR, Khan MA, Kimmick GG, Gupta S, Kenan K, Peswani N, Hershman DL, Ernst BJ, Harvey BE, Krings G, McAndrew NP, Riaz IB, Vaz-Luis I, Villarreal-Garza C, Oberoi JK, Sadiq MH, He H, Chitale R, Hassett MJ. Medical Therapy for Hormone Receptor-Positive, HER2-Negative Stage I-III Breast Cancer: ASCO Living Guideline, Version 2026.1.0. J Clin Oncol 2026. PubMed
  • Radford F, Sapers N, Burgess HM, Ort L, Budnik B, Church GM. Automated prototyping of genetic codes. Nature 2026. PubMed
  • Li Y, Laimon YN, Cho H, Vivero M, de Oliveira GR, Seager MD, Delcea A, Savla V, Chen Y, Durmaz YT, Qiu X, Kukreja S, Li R, El Zarif T, Lu W, Van Orden M, Berchuck JE, Bronson RT, Li S, Ji H, Barbie DA, Politi K, Freedman ML, Long HW, Signoretti S, Oser MG. Polycomb Scaffolding Subunit EED Supports the SCLC Neuroendocrine Identity and EGFR-Mutant LUAD to SCLC Transformation. J Clin Invest 2026. PubMed
  • Zhu G, Asada S, Nguyen H, Hirohashi Y, Sun L, Saravanapavan A, Rahmani E, Hrynashka M, Mukkavalli S, Batish M, Shapiro GI, D'Andrea AD. Defective microhomology-mediated end joining in -deficient tumors. Sci Adv 2026; 12:eaed7743. PubMed
  • Diller L, Cherkerzian S, Cinelli AE, Housman D, Gillani R, Hamilton KV, Yeh JM, Bhattacharjee A, Parad RB. Population-based genomic detection of childhood cancer predisposition using newborn dried blood spots. Nat Commun 2026. PubMed
  • Subbiah V, Zhao F, Kudchadkar RR, Sullivan RJ, Chen HX, Gray RJ, Wang V, McShane LM, Rubinstein LV, Patton D, Williams PM, Hamilton SR, Sundaresan TK, Conley BA, Tricoli JV, Arteaga CL, Wright JJ, Harris LN, O'Dwyer PJ, Chen AP, Flaherty KT. ERK1/2 Inhibitor Ulixertinib in Pan-cancer Patients with BRAF Fusions or Non-V600E/K Mutations: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol Z1L. Clin Cancer Res 2026. PubMed
  • Shi DD, Calvo Fernández E, Puliyappadamba VT, Lanman TA, Xiao Y, Wen Z, Minor M, Prost D, Lasica AB, Cai F, Neumann E, Gudipelly S, Clark LM, Nguyen QD, Peña S, Wansapura J, Kaphle P, Shipman T, Levitt MM, Lin MD, Tsai AC, Lee JH, Cahill DP, Rahman R, Haas-Kogan DA, Richardson TE, Tirosh I, Jain P, Tron AE, Nakhate V, Youssef G, Dehais C, Jacob J, Reardon DA, Miller JJ, Abdullah KG, Wen PY, DeBerardinis RJ, Xu L, Touat M, Peters KB, Gonzalez Castro LN, Kaelin WG, Suvà ML, McBrayer SK. Vorasidenib improves response to subsequent chemoradiation in a genetically engineered mouse model of IDH-mutant glioma. Sci Transl Med 2026; 18:eaee5876. PubMed
  • ElHarouni D, Al-Jazrawe M, Choi S, Dede M, Hinoue T, Misek SA, Noh H, Zanella L, Tseng YY, Francies HE, Plenker D, Kyi CW, Perez-Mayoral J, Stine MJ, Tonsing-Carter E, Agarwal R, Zenklusen JC, Clinton JM, Shelton JM, Chu TR, Hooper WF, Loinaz X, Keskula P, Tagle J, Kuhlers PC, Tercan B, Boj SF, Vasciaveo A, Tomassoni L, Crawford JM, Walsh S, Sinai C, Bhatia S, Sridevi P, Patel H, Cerone MA, , Ellrott K, Kuo CJ, Elemento O, Beyaz S, Corbo V, Spector DL, Beroukhim R, Ferguson ML, Cherniack AD, Laird PW, Robine N, McPherson A, Hoadley KA, Garnett MJ, Tuveson DA, Califano A, Spellman PT, Ligon KL, Gerhard DS, Staudt LM, Boehm JS. A compendium of next-generation patient-derived models for diverse cancers. Nature 2026. PubMed
  • Yoon H, Wachter F, Barrett KA, Jin C, Rodríguez-Pöhnlein A, Rutter JC, Lumpkin RJ, Metivier RJ, Donovan KA, Baek K, Jiang Y, Lee M, Kalis RW, Che J, Xiong Y, Fischer ES, Ebert BL. DCAF11-dependent molecular glue degrader activated by glutathionylation. Nature 2026. PubMed
  • Ng K, Ou FS, Zemla T, Jackson NA, Kalyan A, Devoe C, Shusterman M, Vijayvergia N, Wu CS, Cohen SA, Pulsipher S, Shergill A, Watson Y, Kleiber B, Lee M, Kohn CG, Thalappillil JS, Schwartz LH, Zuckerman D, Hollis BW, O'Reilly EM, Meyerhardt JA. Addition of High-Dose Vitamin D3 to Standard Treatment in Patients With Metastatic Colorectal Cancer: The SOLARIS Randomized Clinical Trial (Alliance A021703). JAMA 2026. PubMed
  • Nolazco JI, Iezzoni LI, Chen EC, Park ER, Wang W, Leapman MS, Alkhatib KY, Teoh JYC, Cole AP, Mossanen M, Lay AH, Bartels SJ, Kibel AS, Feldman AS, Chang SL. Disability Status and Prostate Cancer Screening Among US Men Aged 55 to 69 Years. JAMA Netw Open 2026; 9:e2627708. PubMed
  • Davids MS, Eyre TA, Woyach JA, Roeker LE, Ferrajoli A, Wang Y, Tam CS, Jurczak W, Zinzani PL, Šimkovič M, Li JY, Bosch F, Roos-Weil D, Cramer P, Osterborg A, Islam P, Jacobs R, Skarbnik A, Bhat SA, Kang S, Chen M, Nguyen B, McNeely SC, Chung KL, Oliveira JM, Ito R, Ghia P, Wierda WG. Fixed-duration pirtobrutinib plus venetoclax-rituximab versus venetoclax-rituximab for patients with previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (BRUIN CLL-322): an open-label, multicentre, randomised, controlled, phase Lancet 2026; 408:453-470. PubMed
  • Mendez-Dorantes C, Kalinowski JC, Burn A, Schofield P, Law CT, Isik E, Burns KH. LINE-1 insertion intermediates recombine with one another or with DNA breaks to form genome rearrangements. Nat Commun 2026. PubMed
  • Vanderwall DR, Huttlin EL, Mintseris J, Yaron-Barir TM, Johnson JL, Dong KD, Bott AJ, He Y, Schroeter CB, Frere GA, Uduman M, Lee H, Landry S, Beausoleil SA, Paulo JA, Cantley LC, Gygi SP. An AI-enabled structural atlas decodes kinase specificity across the human proteome. Nat Biotechnol 2026. PubMed
  • Lee E, Karagenova R, Lu C, Farokh P, Azin M, Repetto F, Jobbagy S, Nazarian RM, Reynolds K, Demehri S, Saylor PJ, Fuksman L, Semenov YR. Enfortumab Vedotin-Induced Cutaneous Toxic Effects and Survival in Urothelial Carcinoma. JAMA Dermatol 2026. PubMed
  • Shettigar M, Moulière S, Isenegger L, DeVine AL, Gstalder C, Koduri V, Doench JG, Ksander B, Garcia-Marcos M, Kaelin WG, Haq R. Oncogenic Gα signaling requires AP-3-dependent recruitment to the endolysosomal compartment. Proc Natl Acad Sci U S A 2026; 123:e2615774123. PubMed
  • Torlai Triglia E, Miller TE, Durand NC, Kim KL, Casaní-Galdón S, D'Antonio J, Javed N, Paz Hernandez A, Raman A, Cruz AJ, Issner R, Choudhary A, Aguet F, Verga J, Chan M, Ramanathan V, Li CM, Hecht V, Hansen AS, Aryee MJ, Epstein CB, Kelley DR, Najm FJ, Shoresh N, Ardlie K, Hendrickson DG, Ruby JG, Bernstein BE, Gaskell E. Chromatin topology and distal elements underlie divergent cell-type-specific regulation of 9p21 locus cell cycle genes. Cell Genom 2026. PubMed
  • Chi X, Wang CH, Parisotto YF, Nyberg WA, Cabric V, Gelineau A, Cao Y, Owen DL, Ambjörnsson J, Mathis D, Eyquem J, Brown CC, Benoist C. TCR origin and specificity to environmental or self-antigens on distinct antigen-presenting cells determine peripheral Treg cell differentiation. Immunity 2026. PubMed
  • McKay RR, Ballman KV, Atherton PJ, Ajmera A, Al Baghdadi T, Baumann BC, Beltran H, Berg S, Chen RC, Choudhury AD, Cole S, Jacene HA, Lang JM, Kilari D, Kwok Y, McGregor B, Morris MJ, Parikh M, Swami U, Tan A, Yang YA, Zhang T, Galsky M, Rosenberg J, George D, Choueiri TK. Phase II Randomized Trial of Radium-223 Dichloride and Cabozantinib in Patients With Renal Cell Carcinoma With Bone Metastases: RADICAL (Alliance A031801). J Clin Oncol 2026. PubMed
  • Yang D, Harry SA, Chong HB, Khandelwal N, Zhang E, Nordenfelt NS, Chen N, Lee C, Kaluziak ST, Codd EM, Trivedi S, Gohar M, McKnight G, Mitchell DR, Ge M, Gao C, Holmes Z, Yang W, Smith AE, Carlin AD, Lazarov MJ, Ibrahim SM, Takahashi M, Zhang S, Leong HXY, Luna HM, Stevens R, Mullin PS, Ignashkina A, Chearavanont Z, Emonds K, Popoola G, Barakat IA, Onozato ML, Mahamdeh M, Fujino T, Gerhartz J, Ackerman EE, Koh HY, Naranbhai V, Seo HS, Dhe-Paganon S, Sun ZJ, Heffron GJ, Hata AN, Soberman RJ, Nowak RP, Ott CJ, Liau BB, Iafrate AJ, Bar-Peled L. Systematic Targeting of Protein Complexes with Molecular COUPLrs. Cancer Discov 2026. PubMed
  • Danning R, Ke ZT, Lin X, Ma R. Trajectory-informed gene feature selection in single-cell analysis with SEEK-VFI. Cell Rep Methods 2026. PubMed
  • Leick MB, Sun B, Birocchi F, Gallagher KME, Bratt A, Han S, Martin G, Silva HJ, Larson RC, Chinsky TM, Chu H, Reilly CR, Kann MC, Choi BD, Camp S, Gillani R, Phillips M, Kienka T, Bailey SR, Graham CE, Jan M, Moore NS, Horick N, Budka J, Filosto S, Williams CM, Hosseini Rad A, Shen RR, Van Allen E, AlDubayan S, Maus MV. Genomic correlates of clinical CAR T cell activity. Sci Immunol 2026; 11:eaef4134. PubMed
  • Nguyen YTM, Pfefferlé M, Oh J, Simpson GG, Walker SA, Noguchi S, Garris CS, Deutsch-Williams RJ, Wirapati P, De Stefano F, Goemans M, Dai R, Vinegoni C, Fernández Del Castillo C, Liss AS, Pittet MJ, Weissleder R. Driving tumor-associated macrophages to a CXCL9/SPP1 phenotype eliminates pancreatic cancer. Cell Rep Med 2026. PubMed
  • Nagler A, Sud A, Ghannam JY, Pomerance L, Robles-Oteiza C, Afeyan AB, Weir JA, Russell AJC, Lu WS, Van Orden M, Sonnenholzner A, Marrero GJ, Gong Q, Kumar V, Huang K, Tu C, Lin E, Shim B, De Oliveira GR, Sellars MC, Yoon CH, Reardon DA, Choueiri TK, Olsen LR, Signoretti S, Ott PA, Braun DA, Oliveira G, Li S, Livak KJ, Hacohen N, Chen F, Wu CJ. Single-nucleus multimodal spatial transcriptomics reveals spatial colocalization of neoantigen-expressing tumor cells and cognate T cells. Nat Biotechnol 2026. PubMed
  • Afeyan AB, Nagler A, Tu CR, Roberti De Oliveira G, Simsek B, Seager MD, El Ahmar N, Sax HE, Lin E, Sud A, Borji M, Forman C, Liu S, Ott PA, Choueiri TK, Abelin JG, Burack R, Li S, Livak KJ, Tyekucheva S, Keskin DB, Chen F, Atkins MB, Simon JM, Signoretti S, Oliveira G, Braun DA, Wu CJ. Tertiary lymphoid structures harbour stem-like tumour-specific T cells. Nature 2026. PubMed
  • Wright SJ, Kang S, An M, Heo YJ, Parikh M, Bi L, Lee H, Moorhead G, Haradhvala N, Lim SH, Kim ST, Getz G, Hacohen N, Lee J, Mehta A, Klempner SJ, Park RJ. Differential T cell clonal dynamics underlie outcomes to frontline chemoimmunotherapy in advanced gastric cancer. Cell Rep Med 2026; 7:102910. PubMed
  • Asada S, Zhu G, Abeykoon JP, Tanaka Y, Nguyen H, Hirohashi Y, Iyer DR, Ashton NW, Mukkavalli S, Velazquez M, Jiang L, Del Busso M, Thangaiah JJ, Robinson SI, Parmar K, Van Allen EM, Gillani R, Shapiro GI, D'Andrea AD. Disruption of microhomology-mediated end joining in Ewing sarcoma. Mol Cell 2026. PubMed
  • Lee CY, Smith JS, Kohlmann T, Meara EM, Pham U, Kwarcinski F, Dates AN, Orofino JK, Choi I, Hilibrand AS, Jassal C, Gilmer A, Blacklow SC, Tall GG, Kruse AC, Rajagopal S. β-arrestin recruitment facilitates a direct association with G proteins. Nat Commun 2026. PubMed
  • Orchard P, Blackwell TW, Kachuri L, Castaldi PJ, Cho MH, Christenson SA, Durda P, Gabriel S, Hersh CP, Huntsman S, Hwang S, Joehanes R, Johnson M, Li X, Lin H, Liu CT, Liu Y, Mak ACY, Manichaikul AW, Paik DT, Saferali A, Smith JD, Taylor KD, Tracy RP, Wang J, Wang M, Weinstock JS, Weiss J, Wheeler HE, Zhou Y, Zöllner S, Wu JC, Mestroni L, Graw S, Taylor MRG, Ortega VE, Johnson WC, Gan W, Abecasis G, Nickerson DA, Gupta N, Ardlie K, Woodruff PG, Bowler RP, Meyers DA, Reiner A, Kooperberg C, Ziv E, Vasan RS, Larson MG, Cupples LA, Silverman EK, Rich SS, Heard-Costa N, Tang H, Rotter JI, Smith AV, Levy D, , , Aguet F, Scott LJ, Raffield LM, Parker SCJ, Abe N, Almasy L, Ament S, Anugu P, Auer P, Avramopoulos D, Balasubramanian A, Barr RG, Barwick L, Beaty T, Becker D, Becker L, Beitelshees A, Benos T, Bezerra M, Bis J, Brody J, Broeckel U, Broome J, Bunting K, Buth E, Carey V, Carty C, Casaburi R, Chaffin M, Chang C, Chang YC, Chavan S, Chen BJ, Chen WM, Choi SH, Chuang LM, Chung RH, Conomos M, Cornell E, Crandall C, Crapo J, Curtis J, Damcott C, David S, de Las Fuentes L, de Vries P, Deka R, DeMeo D, Devine S, Dinh H, Doddapaneni H, Duan Q, Duggirala R, Eaton C, Ekunwe L, El Boueiz A, Emery L, Farber C, Farek J, Franceschini N, Frazar C, Fu M, Fullerton SM, Fulton L, Gao S, Gao Y, Gass M, Geiger H, Ghosh A, Gignoux C, Glahn D, Gogarten S, Gong DW, Goring H, Grine D, Gu CC, Guan Y, Hall M, Han Y, Harris D, Heavner B, Herrington D, Hobbs B, Hong E, Hoth K, Hsiung CA, Hu J, Hung YJ, Huston H, Hwu CM, Jackson R, Jain D, Johnsen J, Johnston R, Jones K, Kessler M, Khan A, Khan Z, Kim W, Kimoff J, Kinney G, Kramer H, Lange C, Lange E, Laurie C, Laurie C, LeBoff M, Lee S, Lee WJ, Levine D, Lewis J, Li Y, Lin X, Liu S, Liu Y, Make B, Manning A, Manson J, Martin L, Marton M, Mathai S, May S, McArdle P, McDonald ML, McFarland S, McGoldrick D, McHugh C, Mei H, Meigs J, Menon V, Min N, Moll M, Momin Z, Montasser M, Mychaleckyj JC, Naik R, Naseri T, Natarajan P, Nelson SC, Neltner B, Nessner C, Nkechinyere O, O'Connell J, O'Connor T, Ochs-Balcom H, Okwuonu G, Pankow J, Parker C, Peloso G, Peralta JM, Perez M, Perry J, Peters U, Phillips LS, Pollin T, Becker JP, Boorgula MP, Psaty B, Qiao D, Rafaels N, Rajendran M, Rasmussen-Torvik L, Ratan A, Reed R, Regan E, Reupena MS, Robillard R, Roselli C, Ruczinski I, Runnels A, Russell P, Ryan K, Sabino EC, Salimi S, Salvi S, Salzberg S, Sandow K, Santibanez J, Schwander K, Sciurba F, Sériès F, Shetty A, Shetty A, Silver B, Skomro R, Smith T, Smoller S, Snively B, Stilp AM, Storm G, Streeten E, Su JL, Sung YJ, Sylvia J, Szpiro A, Taub M, Taylor S, Thornton TA, Threlkeld M, Tinker L, Tirschwell D, Tiwari H, Tong C, Tsai M, Vaidya D, Walker T, Wallace R, Walts A, Wang FF, Wang H, Watson K, Watt J, Weng LC, Wessel J, Williams K, Wilson C, Wilson J, Winterkorn L, Wong Q, Wu B, Xu H, Yanek L, Yang I, Zekavat SM, Zhao SX, Zhao W, Zhu X. Cross-cohort analysis of expression and splicing quantitative trait loci in TOPMed. Science 2026; 393:eadx2989. PubMed
  • Ravani LV, Bagheri Z, Kalinsky K, Burstein HJ, Bardia A, Mouabbi JA, O'Regan R, Wander SA. Progression-Free Survival in Metastatic Breast Cancer by Local Investigators vs Blinded Independent Central Review: A Systematic Review and Meta-Analysis. JAMA Oncol 2026. PubMed
  • Urbut SM, Ding Y, Nakao T, Koyama S, Misra A, Jiang X, Harish A, Gaffney L, Hornsby WE, Smoller JW, Gusev A, Natarajan P, Parmigiani G. A Bayesian framework for longitudinal EHR and genetic discovery. Nature 2026. PubMed
  • Tang J, Pernes G, Nakagaki B, Tran N, Bokor L, Prenen F, Yi M, Robertson AE, Cronin R, Sarmini M, Pierscianowski J, Roberts V, Ryback BA, Novina CD, Auclair K, Xiao H, Mills EL. Macrophage-derived itaconate is a negative regulator of adipose tissue thermogenesis. Nat Metab 2026. PubMed
  • Park ER, Sicks JD, Goshe BM, Gareen IF, Herman BA, Taurone A, Bittig S, Walter AW, Regan S, Rosen R, Durieux N, Rasmussen AW, Levy DE, Nicolosi G, Muzikansky A, Thompson MA, Lui M, Malloy L, Gonzalez I, Finkelstein-Fox L, Munson ND, Greenwade MM, King DM, Jenigiri B, Burnette BL, Throckmorton AD, Tingen MS, Carlos RC, Wagner LI, Ostroff JS. Virtual Sustained Tobacco Treatment for Patients With Cancer: A Randomized Controlled Trial (ECOG-ACRIN: EAQ171CD) Within the National Cancer Institute Community Oncology Research Program. J Clin Oncol 2026. PubMed
  • Al-Samkari H, Shatzel JJ, Panch SR, Keating JH, Walsh EP, Weekes CD, Kardosh A, Cohen SA, Cohen JJ, Hodges PG, Dhaver SE, Strojny N, Donovan C, Belibasakis C, Soff GA. Avatrombopag Versus Placebo for Persistent Chemotherapy-Induced Thrombocytopenia in GI Cancers: The Phase II ACT-GI Trial. J Clin Oncol 2026. PubMed
  • Ojeda S, Wang M, Baek K, Bourgeois W, Sommerschield A, Yue H, Metivier RJ, Karagiannis P, Levitz TS, Xiong Y, Donovan KA, Armstrong SA, Fischer ES. Degron-independent recruitment of KAT2A expands the target space of CRBN molecular glues. Science 2026; 393:188-194. PubMed
  • Zhang X, Xirenayi S, Zhao Y, Wang W, Han Y, Sobral M, Kang S, Zhang C, Barlow GL, Pyrdol J, Cho JW, Huang K, Ning X, Hemberg M, Yuan GC, Van Allen EM, Mooney DJ, Wucherpfennig KW. The CARM1 epigenetic enzyme inhibits cross-presenting dendritic cell function in cancer immunity. Science 2026; 393:eaea1200. PubMed
  • Glassman CR, Baek K, Hou G, Zeng Q, Nardone C, Juergens KB, Fujimura E, O'Leary CN, Li MZ, Paulo JA, Fischer ES, Ding S, Harper JW, Elledge SJ. Virome-wide ubiquitin ligase discovery reveals diverse mechanisms of immune evasion. Science 2026. PubMed
  • Casirati G, Cosentino A, Freschi M, Zeng J, Mucci A, Levesque S, Neri N, Drago E, Carzaniga V, Romano F, Katta V, Matsubara A, Li Y, Mahmoud MS, Chávez-Navarro M, Brendel C, Manis JP, Tsai S, Pellin D, Bauer D, Genovese P. Non-genotoxic transplantation and in vivo selection through epitope editing. Nature 2026. PubMed
  • Guerrera ML, Liu X, Tsakmaklis N, Peachey AL, Kofides A, Hatcher J, Ramirez Gamero A, Guijosa A, Yang G, Sun H, Liu S, Patterson CJ, Meid K, Flynn C, Carrasco RD, Branagan AR, Sarosiek SR, Castillo JJ, Anderson KC, Munshi N, Treon SP, Hunter ZR. WNK2 oncogenicity revealed by the discovery and functional characterization of novel gene isoforms in MYD88 mutated Waldenström's Macroglobulinemia. Blood Cancer J 2026. PubMed
  • Hao J, Kochupurakkal B, Branigan TB, Somuncu OS, Liu R, Jadhav H, da Costa AAB, Jiao Y, Yu JZ, Martignetti DB, Sadatrezaei G, Mukkavalli S, Gokhale PC, Cheng SC, Skates SJ, Nasioudis D, Konstantinopoulos PA, Liu JF, Gaillard SL, Giuntoli Ii RL, Martin LP, Tanyi JL, Latif N, Heller IS, Simpkins F, Parmar K, D'Andrea AD, Shapiro GI. PTEN deficiency confers sensitivity to ATR inhibitor-based treatment in high-grade serous ovarian cancer. J Clin Invest 2026. PubMed
  • Huang K, Miao T, Chen Y, Dantas E, Sanford J, Asara JM, Moon SJ, Hu Y, Wang K, Han M, Goncalves M, Perrimon N. Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth in Drosophila. Nat Commun 2026. PubMed
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