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  • Shaw J, Marin MG, Li H. High-resolution metagenome assembly for modern long reads with myloasm. Nat Biotechnol 2026. PubMed
  • Han S, Zhao D, Chen X, Zhu M, Li T, Wang C, Chen H, Li Z. Transient adenovirus-Cre infection causes long-lasting remodeling of the mammary gland immune landscape. Sci Rep 2026. PubMed
  • Petsakou A, Filine E, Li M, Chen Y, Zheng A, Perrimon N. Tumor-induced orexigenic imbalance lowers protein appetite and drives early organ wasting symptoms. Nat Commun 2026. PubMed
  • Cassandras M, Sanchez X, Hsu L, Huang Y, Getzler AJ, Ganguly D, Baldominos P, Codinachs I, Chuong J, Martin EE, Smith BE, Marina E, Spasic M, Qin X, Parsons HA, Mayer EL, Sarosiek KA, Dougan SK, Mittendorf EA, McAllister SS, Hsu YC, Agudo J. A glucocorticoid-FAS axis controls immune evasion during metastatic seeding. Nature 2026. PubMed
  • Jones E, Naranjo A, Winestone LE, Umaretiya PJ, Aziz-Bose R, Kelly CA, Newman H, Zheng DJ, Greengard E, Bagatell R, DuBois SG, Bona K. Collecting Social Determinants of Health in a Children's Oncology Group Trial for High-Risk Neuroblastoma. JAMA Netw Open 2026; 9:e260419. PubMed
  • Hanna GJ, Zamulko OY, Grover P, Adkins DR, Oppelt PJ, Romano AE, Lehn MA, Bachmann LM, Wikenheiser-Brokamp KA, Lemmon CA, Forsythe AJ, Allen CL, Pan J, Rai SN, El-Gamal D, Wise-Draper TM. Amivantamab for Recurrent or Metastatic Adenoid Cystic Carcinoma: A Phase 2 Nonrandomized Clinical Trial. JAMA Otolaryngol Head Neck Surg 2026. PubMed
  • Heltberg MS, Jimenez A, Lahav G, Jensen MH. Genetic resonance in the p53 signaling network. Cell Syst 2026. PubMed
  • Fiskin E, Eraslan G, Alora-Palli MB, Jain T, Leyva-Castillo JM, Kim S, Choe H, Lareau CA, Lau H, Finan EP, Teixeira-Soldano I, LaBere B, Chu A, Woods B, Chou J, Slyper M, Waldman J, Islam S, Schneider L, Phipatanakul W, Platt C, Rozenblatt-Rosen O, Delorey TM, Ashenberg O, Deguine J, Smith GP, Geha RS, Regev A, Xavier RJ. Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis. Nat Commun 2026. PubMed
  • Rolles B, Filho CMO, Fergusson N, Bewersdorf JP, Keating J, Perkins C, Schwede M, England J, Luskin MR, DeAngelo DJ, Shimony S, Faiz M, Hillerbrand AC, Kim C, Weeks LD, Waldman L, Wazir M, How J, Marneth AE, Liu Y, Aryee MJ, Rampal R, Tsai HK, Gotlib J, Gupta V, Stahl M, Mullally A. Risk stratification of patients with TP53-mutated myeloproliferative neoplasms. Leukemia 2026. PubMed
  • Meader E, Walcheck MT, Leder MR, Delaney P, Falchetti M, Jing R, Li C, Kambli NK, Wrighton PJ, Sugden WW, Najia MA, Oderberg IM, Taylor VM, LeBlanc ZC, Quenzer ED, Lim SE, Schlaeger T, Daley GQ, Goessling W, North TE. Bnip3lb-driven mitophagy maintains fate of the embryonic hematopoietic stem cell pool. Nat Commun 2026. PubMed
  • Singh R, Venkadakrishnan VB, Imada E, Yamada Y, Brady NJ, Dunmore KE, Garner R, Booker MA, Hanratty B, Haffner MC, Tolstorukov MY, Marchionni L, Robinson BD, Rickman DS, Beltran H. Crosstalk between EZH2 and DNA methylation mediates neuroendocrine prostate cancer lineage plasticity. Nat Commun 2026. PubMed
  • Camp SY, He MX, Cuoco MS, Garza AE, Xirenayi S, Bakouny Z, Saad E, El Masri J, Pimenta E, Meli K, Labaki C, Titchen BM, Kang YJ, Horst J, Trowbridge R, Shannon E, Helvie K, Thorner AR, Vigneau S, Mayorga A, Kodali J, Lachmayr H, Bemus M, Chen P, Deng H, Park J, Choueiri TK, Bi K, Van Allen EM. Single-cell epigenetic profiling reveals a tumor-intrinsic interferon response program in ccRCC tied to poor prognosis and loss. Sci Adv 2026; 12:eadv5457. PubMed
  • van Tienen LM, Bayoumi S, Muneeruddin K, Leymarie N, Popa A, Shekhar M, Mueller M, Li R, Zak KM, Chilukuri H, Kornfilt DJP, Atack TC, Kesar D, Bian Y, Shaw KL, Jandova Z, Trollmann P, Geist L, Stolt-Bergner P, Rumpel K, Kessler D, Sellers WR. Systematic cysteine scanning identifies a druggable pocket in oncogenic KRAS. Cell Chem Biol 2026; 33:241-255.e8. PubMed
  • Yamaguchi S, Fernandez SG, Wassarman DR, Lüders M, Schwede F, Kranzusch PJ. Nucleotide signals coordinate activation and inhibition of bacterial immunity. Nature 2026. PubMed
  • Xie F, Gjyrezi A, Fein D, Labaf M, Poluben L, Ersoy-Fazlioglu B, Dennehy CM, Voznesensky O, Gad A, Corey E, Varkaris A, Einstein DJ, Bhatt RS, Giannakakou P, Balk SP. FOXJ1 mediates taxane resistance through regulation of microtubule dynamics. Nat Commun 2026. PubMed
  • Meylan M, Tian Y, Wu L, Ling AL, Kovarsky D, Barlow GL, Nguyen LD, Pyrdol J, Marx S, Westphal L, Michel J, Gonzalez Castro LN, Dumont S, Santos A, Tirosh I, Suvà ML, Chiocca EA, Wucherpfennig KW. Persistent T cell activation and cytotoxicity against glioblastoma following single oncolytic virus treatment in a clinical trial. Cell 2026. PubMed
  • Lu S, Yin Z, Wu L, Sun Y, Chen J, Wu LMN, Oblinger JL, Blake DC, Xiu B, Landegger LD, Seist R, Ho W, Jones AP, Muzikansky A, Stankovic KM, Plotkin SR, Chang LS, Xu L. NKG2D upregulation sensitizes tumors to combined anti-PD1 and anti-VEGF therapy and prevents hearing loss. Nat Commun 2026; 17:1148. PubMed
  • Rojas-Jimenez E, Bui TM, Yan P, Li Z, Seehawer M, Nishida J, Foidart P, Freeman GJ, Polyak K. Evaluation of targeted and immune combination therapies in a rat model of hormone receptor-positive breast cancer. Proc Natl Acad Sci U S A 2026; 123:e2501052123. PubMed
  • Manakongtreecheep K, Ctortecka C, Correa-Medero LO, Zhu T, Lippincott I, Lawrence GM, Howard A, Hernandez GM, Forman C, Duggan EC, Wilbrink MA, Verzani EK, Afeyan AB, Li J, Nesvizhskii AI, Oliveira G, Keskin DB, Ott PA, Clauser KR, Bakalar M, Sarkizova S, Hacohen N, Carr SA, Abelin JG, Wu CJ. Sensitive detection of cancer antigens enabled by user-defined peptide libraries. Nat Biotechnol 2026. PubMed
  • Tak D, Garomsa BA, Zapaishchykova A, Chaunzwa TL, Climent Pardo JC, Ye Z, Zielke J, Ravipati Y, Pai S, Vajapeyam S, Mahootiha M, Parker M, Pike LRG, Smith C, Familiar AM, Liu KX, Prabhu S, Arnaout O, Bandopadhayay P, Nabavizadeh A, Mueller S, Aerts HJ, Huang RY, Poussaint TY, Kann BH. A generalizable foundation model for analysis of human brain MRI. Nat Neurosci 2026. PubMed
  • Dussel V, Orellana L, Requena ML, Avery M, Becker D, Ullrich CK, Feudtner C, Freedman JL, Kang TI, Waldman ED, Gerhardt CA, Bakitas MA, Baker JN, Friedrichsdorf SJ, Rosenberg AR, Wolfe J. Integrating Electronic Patient-Reported Outcomes and Palliative Care in Pediatric Advanced Cancer: The PediQUEST Response Multisite Randomized Controlled Trial. J Clin Oncol 2026. PubMed
  • Hwang JC, Huhmann LB, Cho K, Goryachev SD, Starink N, Weinstock MA, Asgari MM, Zheng C, Lu C, Feldman TC, Do NV, Gaziano JM, Semenov YR, Hurlbert MS, Fillmore NR, Hartman RI. Identification of Risk Factors for Acral Melanoma in US Veterans. JAMA Dermatol 2026. PubMed
  • Cheng H, Qu H, McKenzie S, Lawrence KR, Windsor R, Vella M, Park PJ, Li H. Efficient near-telomere-to-telomere assembly of nanopore simplex reads. Nature 2026. PubMed
  • Orchard SG, Polekhina G, Zalcberg J, Bernstein W, Macrae F, Tie J, Gately L, Mar V, Millar J, Rodriguez LM, van Londen GJ, Kent A, Hiscutt E, Ong WL, Warner ET, Ford L, Umar A, McNeil JJ, Nelson M, Stocks N, Shah RC, Kirpach B, Murray A, Woods RL, Ryan J, Wolfe R, Gibbs P, Chan AT. Cancer Incidence and Mortality With Aspirin in Older Adults: Follow-Up of the ASPREE Trial. JAMA Oncol 2026. PubMed
  • Tung NM, Robson ME, Li T, Nanda R, Shah PD, Khoury K, Kimmick G, Santa-Maria C, Brufsky A, DeMeo M, Vieira JP, Carey LA, Wulf G, Domchek S, Krop IE, Wolff AC, Winer EP, Garber JE, . TBCRC 048 (Olaparib Expanded) Expansion Cohorts: Phase II Study of Olaparib Monotherapy for Patients With Metastatic Breast Cancer With Germline Mutations in or Somatic Mutations in or . J Clin Oncol 2026. PubMed
  • Chai P, Kheiri S, Kuo A, Shah J, Kageler L, Ge R, Perr J, Porat J, Lebedenko CG, Dias JML, Yankova E, Rai SK, Watkins CP, Hristov P, Tzelepis K, Hla T, Raman R, Calo E, Esko JD, Flynn RA. GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling. Nature 2026. PubMed
  • Ewen-Campen B, Chen W, Tattikota SG, Liu Y, Hu Y, Perrimon N. The Drosophila proventriculus lacks stem cells but compensates for age-related cell loss via endoreplication-mediated cell growth. Nat Commun 2026. PubMed
  • Verma P, Gowda P, Danial NN, Van Vactor D. A brain-specific microRNA, , regulates lipid homeostasis via neuropeptide-like precursor 1 in . Genes Dev 2026. PubMed
  • Blumenberg V, Birocchi F, Shih A, Escobar G, Mucci A, Armstrong A, Cirstea DD, Harris DL, Bozym DJ, Puliafito BR, Newcomb RA, Dhawale TM, Johnson PC, El-Jawahri A, Jeffrey R, Barselau A, Li A, Emmanuel-Alejandro E, Cook D, Lindell KA, Luk SO, Chaffee R, Yee AJ, Branagan AR, Raje NS, Graham C, Hammond SP, Bushman FD, Roche AM, Reddy S, McFarland AG, Chen YB, Choi BD, Mount CW, Dougan M, Nardi V, Sohani A, Gallagher KME, Maus MV, Frigault MJ, Leick MB. Ruxolitinib for Ciltacabtagene Autoleucel-Associated Refractory Diarrhea. Blood 2026. PubMed
  • Slater JM, Horick NK, Nachtigall LB, Parsons MW, Tritos NA, Faje AT, Dietrich J, Fullerton B, Sherman JC, Curry WT, Arrillaga-Romany IC, Cahill DP, Nahed BV, Wang IS, Botticello TM, Oh KS, Yeap BY, Shih HA. Cognitive Function, Quality of Life, and Survival Outcomes in Patients with Lower Grade Gliomas Treated with Proton Radiation Therapy: A Phase II study. 2026. PubMed
  • Tsopoulidis N, Yagi M, Brumbaugh J, Ito S, López-Soriano V, Morris R, Yoon Y, Messemer KA, Lin KH, Zaniewski EF, Gorelov R, Huebner AJ, Wagers AJ, Hock H, Kramer G, Bukau B, Hoetker MS, Shi Y, Haas W, Hochedlinger K. Modulation of Nudt21 levels reveals dose-dependent roles of alternative polyadenylation in tissue regeneration. Nat Commun 2026. PubMed
  • Tolaney SM, de Azambuja E, Kalinsky K, Loi S, Kim SB, Yam C, Rapoport B, Im SA, Pistilli B, Mchayleh W, Cescon DW, Watanabe J, Bañuelas MAL, Freitas-Junior R, Salvador Bofill J, Afshari M, Gary D, Wang L, Lai C, Schmid P, . Sacituzumab Govitecan plus Pembrolizumab for Advanced Triple-Negative Breast Cancer. N Engl J Med 2026; 394:354-366. PubMed
  • Pimenta EM, Garza AE, Camp SY, Park J, Hoffman SE, Valderrábano L, Fu J, Bi K, Carson MT, Karam J, Titchen BM, Medjahed S, Khandekar MJ, Shannon E, Kang YJ, Coy S, Lin JR, Nag A, Thorner AR, Gibson WJ, Santagata S, Raut CP, Hornick JL, Merriam P, Solimini NL, George S, Demetri GD, Van Allen EM. Epigenetic dysregulation of metabolic programs mediates liposarcoma cell plasticity. Sci Transl Med 2026; 18:eadw4689. PubMed
  • Coleman N, Wei Z, Iafrate AJ, Zwiebel JA, Sharon E, Gray RJ, Wang V, McShane LM, Rubinstein LV, Patton DR, Williams PM, Hamilton SR, Takebe N, Williams T, Croley JJ, Onitilo AA, Tricoli JV, Cheng J, Karlovich C, Conley BA, Arteaga CL, Harris L, O'Dwyer PJ, Hong DS, Chen AP, Flaherty KT. Crizotinib in Patients with Tumors with MET Amplification or Exon 14 Deletion: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocols C1 and C2. Clin Cancer Res 2026. PubMed
  • Valenza C, Zheng Y, Milano M, Trapani D, Giordano E, Guidi L, Berton Giachetti PPM, Boldrini L, Castellano G, Katrini J, Malagutti B, Antonarelli G, Conforti F, Pagan E, Bagnardi V, Kirkner GJ, Sangalli C, Dibble KE, Colleoni M, Regan MM, Munzone E, Curigliano G, Partridge AH. Extended Endocrine Therapy Following 5 Years of Adjuvant Luteinizing Hormone-Releasing Hormone Agonist in Premenopausal Patients With Node-Positive, Hormone Receptor-Positive Breast Cancer: A Cohort Study. J Clin Oncol 2026. PubMed
  • Mishra A, Meador CB, Kikkeri K, Cunneely Q, Lin M, Carmona-LaSalle TJ, Huang SB, Bell R, Putaturo V, Xia W, Liang JH, Fang J, San Vicente S, Zielinski CE, Digumarthy SR, Hung YP, Yeap BY, Edd JF, Lawrence MS, Sade-Feldman M, Sen DR, Toner M, Maheswaran S, Gainor JF, Haber DA. Circulating Tumor Cells Predict Response to the DLL3-targeting Bispecific Antibody Tarlatamab. Cancer Discov 2026. PubMed
  • Fece de la Cruz F, Varkaris A, Patel PS, Kushner EW, Morales-Giron AA, Lee SS, Singh A, Kim CT, Norden BL, Ehnstrom S, Riedl JM, Curtis JM, Barnes H, Kehlmann AM, Chevalier NJ, Okuma HS, Patel M, Wirth LJ, Connell B, Nugent F, Pappas L, Lau K, Juric D, Hopkins JL, Guiley KZ, Shokat KM, Gulhan DC, Parikh AR, Corcoran RB. Acquired on-target alterations drive clinical resistance to p53-Y220C reactivators. Cancer Discov 2026. PubMed
  • Gonzales F, Schneider C, Alexe G, Lin S, Khalid D, Alvarez M, Basanthakumar A, Ellegast JM, Merickel L, Salhotra S, Taillon A, Giaimo M, Wunderlich M, Ansari M, Perry JA, Degar B, Pikman Y, Stegmaier K. Identifying targeted therapies for CBFA2T3::GLIS2 acute myeloid leukemia. Leukemia 2026. PubMed
  • Silverbush D, Jürgensen L, Freeburg NF, Pooley CS, Boniolo F, Gaiti F, Suvà ML, Hovestadt V. A cellular epigenetic classification system for glioblastoma. 2026. PubMed
  • Weiss A, Braun D, Stopfer J, Zhao J, McGrath M, Bradshaw KR, Rosito MS, Davis D, Garber JE, King TA. Genetic Testing for All Breast Cancer Patients: The GET FACTS Randomized Clinical Trial. JAMA Netw Open 2026; 9:e2551553. PubMed
  • Levy DE, Hassan S, Wint AJ, Marotta C, Gonzalez I, Chang Y, Rigotti NA, Haas JS, Park ER. Economic Evaluation of Tobacco Treatments From the Screen ASSIST Lung Cancer Screening Trial. JAMA Netw Open 2026; 9:e2555332. PubMed
  • Shammas RL, Fish LJ, Petrillo LA, Falkovic M, Makarushka C, Parnell H, Jain A, Slezak SS, Giladi AM, Mehrara BJ, Keating NL, Matros E, Aliu O, Offodile AC. Experiences With Maryland's All-Payer Model Among Surgeons. JAMA Netw Open 2026; 9:e2552815. PubMed
  • Jain SU, Williamson KE, Ying AW, Turner AM, Jiang RJ, Raval S, So K, Allison MJ, Sankar A, Sáme Guerra DD, Lin Y, Jiang Z, Mashtalir N, Rohrs HW, Lichti CF, Muir TW, Papanastasiou M, Paulo JA, Gygi SP, Gross ML, Kadoch C. A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform. Science 2026. PubMed
  • Agarwal G, Antoszewski M, Xie X, Pershad Y, Arora UP, Poon CL, Lyu P, Lee AJ, Guo CJ, Ye T, Norford LB, Neehus AL, Della Volpe L, Wahlster L, Ranasinghe D, Ho TC, Barlowe TS, Chow A, Schurer A, Taggart J, Durham BH, Abdel-Wahab O, McGraw KL, Allan JM, Soldatov R, Bick AG, Kharas MG, Sankaran VG. Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation. Science 2026; 391:52-58. PubMed
  • Zhang CZ, Mendez-Dorantes C, Burns KH, Pellman D. A breakage-replication/fusion process explains complex rearrangements and segmental DNA amplification. Nat Genet 2026; 58:88-99. PubMed
  • McKay RR, Pal S, Xie W, Aggen D, Albiges L, Apolo A, Atkins MB, Bangs R, Beckermann KE, Bellmunt J, Berg SA, Bilen MA, Braun D, Carlo MI, Efstathiou J, Galsky M, Grivas P, Gupta S, Haas N, Hakimi AA, Hammers H, Heng DYC, Hirsch M, Iyer G, Jonasch E, Koshkin VS, Kryvenko O, Lewis B, Li R, Matin S, Maughan B, McDermott DF, McGregor B, Meeks J, Milowsky M, Motzer R, Necchi A, Petrylak D, Porten S, Powles T, Rini B, Shuch B, Siefker-Radtke A, Sonpavde G, Sridhar SS, Suarez C, Tang C, Tripathi A, Van Der Heijden MS, Voss M, Xu W, Zhang T, Rosenberg J, Choueiri TK. Advanced Urologic Cancer Consensus Conference (AUC3) 2025: Expert consensus on the management of renal cell and urinary tract cancers. CA Cancer J Clin 2026; 76:e70052. PubMed
  • Abbott KL, Subudhi S, Ferreira R, Gültekin Y, Steinbuch SC, Munim MB, Ramesh DL, Honeder SE, Kumar AS, Wu M, Hansen JA, Shevzov-Zebrun A, Rashan EH, Eghbalian KM, Sivanand S, Barbeau AM, Riedmayr LM, Duquette M, Ali A, Henning N, Trojan SE, Waite M, Kunchok T, Nakano MA, Gourgue F, Ferraro GB, Do BT, Spanoudaki V, Sánchez-Rivera FJ, Jin X, Church GM, Jain RK, Vander Heiden MG. Nutrient requirements of organ-specific metastasis in breast cancer. Nature 2026; 649:1292-1301. PubMed
  • Van Buren E, Zhang Y, Li X, Selvaraj MS, Li Z, Zhou H, Palmer ND, Arnett DK, Blangero J, Boerwinkle E, Cade BE, Carlson JC, Carson AP, Chen YI, Curran J, Duggirala R, Fornage M, Franceschini N, Graff M, Gu C, Guo X, He J, Heard-Cosa N, Hou L, Hung YJ, Kalyani RR, Kardia SLR, Kenny E, Kooperberg C, Kral BG, Lange L, Levy D, Li C, Liu S, Lloyd-Jones D, Loos RJF, Manichaikul AW, Martin LW, Mathias R, Minster RL, Mitchell BD, Mychaleckyj JC, Naseri T, North K, O'Connell J, Perry JA, Peyser PA, Psaty BM, Raffield LM, Vasan RS, Redline S, Reiner AP, Rich SS, Smith JA, Spitzer B, Tang H, Taylor KD, Tracy R, Viali S, Yanek L, Zhao W, , Rotter JI, Peloso GM, Natarajan P, Lin X. cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions. Nat Methods 2025. PubMed
  • DaSilva LF, Senan S, Kribelbauer-Swietek JF, Patel ZM, Louis LK, Reddy AJ, Gabbita S, Rosen JD, Nussbaum Z, Córdova CMV, Wenteler A, Weber N, Tunjic TM, Mansoldo M, Khan TA, Hwang GH, Gardeux V, Humphreys DT, Smith C, Bejan M, Bromley P, Connell W, Deplancke B, Love MI, Wong ES, Meuleman W, Pinello L. Designing synthetic regulatory elements using the generative AI framework DNA-Diffusion. Nat Genet 2025. PubMed
  • Tzouanas CN, Shay JES, Sherman MS, Rubin AJ, Mead BE, Dao TT, Tao J, Lehrich BM, Eng G, Patterson-Fortin J, Butzlaff T, Mana MD, Kolb KE, Walesky C, Pepe-Mooney BJ, Smith CJ, Prakadan SM, Ramseier ML, Tong YE, Joung J, Chi F, McMahon-Skates T, Winston CL, Jeong WJ, Aney KJ, Chen E, Nissim S, Zhang F, Deshpande V, Monga SP, Lauer GM, Goessling W, Yilmaz ÖH, Shalek AK. Hepatic adaptation to chronic metabolic stress primes tumorigenesis. Cell 2025. PubMed
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