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  • Perrotta RM, Vinke S, Ferreira R, Moret M, Mahas A, Chiappino-Pepe A, Riedmayr LM, Mehra AT, Lehmann LS, Church GM. Engineered base editors with reduced bystander editing through directed evolution. Nat Biotechnol 2025. PubMed
  • Yang H, Gao B, Wu B, Li W, Zhu X, Phoon L, Luo J, Gui F, Zhao W, Jia L, Lan L. cGAS restricts PARP1-mediated microhomology-mediated end joining by suppressing poly-ADP-ribosylation. Cell Death Differ 2025. PubMed
  • Meisel JD, Joshi PR, Spelbring AN, Wang H, Wellner SM, Wiesenthal PP, Miranda M, McCoy JG, Barondeau DP, Ruvkun G, Mootha VK. Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency. Nature 2025. PubMed
  • Mao L, Tian L, Huang B, Richardson PG, Ludmir EB, Hughes MD, Wei LJ. Evaluating Treatment Effects with Patient-Response-Related Outcomes in Comparative Clinical Trials. NEJM Evid 2025; 4:EVIDctw2400349. PubMed
  • Fu J, Waks AG, Pimenta E, Titchen B, Bi K, Camp S, Pappa T, Keenan T, Shannon E, Vigneau S, Bemus M, Nag A, Thorner AR, Park J, DiLullo M, Wrabel E, Jeselsohn R, Mittendorf EA, Abravanel DL, Tolaney SM, Van Allen EM. Cellular reprogramming during anti-PD-1 and chemotherapy treatment in early-stage primary hormone receptor-positive breast cancer. Nat Commun 2025; 16:10704. PubMed
  • Waks AG, Fu J, Chu X, Binboga Kurt B, Li T, Kuntz TM, Shen Y, Yang D, Meli K, Reardon B, Park J, Partridge A, Abravanel D, Jeselsohn R, Wrabel E, Alberti J, DiLullo M, Chen S, Mohammed-Abreu A, Sun X, Balko JM, Kleijn M, Audeh W, Morgan XC, Krop IE, Tayob N, Van Allen EM, Mittendorf EA, Tolaney SM. Efficacy, safety, and predictive biomarkers of neoadjuvant nab-paclitaxel and pembrolizumab in hormone receptor-positive breast cancer: A randomized pilot trial. Nat Commun 2025; 16:10705. PubMed
  • Abu-Remaileh M, Stransky LA, Bhalerao N, Shirole NH, Jiang Q, Saad E, Machaalani M, Vigeant SM, Woldemichael H, Xu C, Lu J, Wei H, Liu Z, Sun W, Enomoto K, Choueiri TK, Pitarresi JR, Carr SA, Udeshi ND, Kaelin WG. Targeting of HIF2-driven cachexia in kidney cancer. Nat Med 2025. PubMed
  • Taylor MS, Chen M, Hancock M, Wranik M, Miller BD, O'Meara TR, Palanski BA, Ficarro SB, Groendyke BJ, Xiang Y, Kondo KT, Linde-Garelli KY, Lee MJ, Mondal D, Freund D, Congreve S, Matas K, Hennink M, Xibinaku K, Valenstein ML, van Eeuwen T, Marto JA, Sali A, Shi Y, Gray NS, Sabatini DM, Chu N, Rogala KB, Cole PA. Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2. Science 2025. PubMed
  • Al-Samkari H, Hessels J, Riera-Mestre A, Dupuis-Girod S, Van Zele T, Gómez Del Olmo V, Hodges PG, Torres-Iglesias R, Bertè R, Saint-Mezard P, Lazar H, Benedict N, Barker D, Bernasconi C, Picard D, Buscarini E, Mager HJ. Engasertib versus Placebo for Bleeding in Hereditary Hemorrhagic Telangiectasia. N Engl J Med 2025; 393:2131-2141. PubMed
  • Leng F, Clark R, Zhang W, Viennet T, Wang C, Arthanari H, Wang X, Hur S. FoxP3 forms a head-to-head dimer in vivo and stabilizes its multimerization on adjacent microsatellites. Cell Rep 2025; 44:116633. PubMed
  • Bird GH, Adhikary U, Schmidt MJ, Godes M, Tesar B, Camara CM, Paulo JA, Vidlak JF, DeAngelo TM, Marquez M, Gokhale P, Li R, Ho Sui SJ, Cameron MD, Gygi SP, Walensky LD. A triple-action PROTAC for wild-type p53 cancer therapy. Cell Rep Med 2025. PubMed
  • Wiggers CRM, Cho EY, Ozdemir M, Bamgbose G, Hegel J, Frede J, Warlitz F, Heavican-Foral TB, Pop I, Shraim R, Pölönen P, Koch V, Tran TH, Mullighan CG, Teachey DT, Bledsoe JR, Pikman Y, Harris MH, Place AE, Silverman LB, Lohr JG, Knoechel B. Remodeling of the immune microenvironment is linked to adverse outcome in pediatric T cell acute lymphoblastic leukemia. Nat Commun 2025; 16:10263. PubMed
  • Newman CE, Gygi MA, Alimohamadi H, DeAngelo TM, Camara CM, Mintseris J, Yu E, Harvey EP, Hauseman ZJ, Fan L, Wang YX, Luo EW, Godes M, Gehtman J, Cathcart AM, Gygi SP, Engen JR, Bird GH, Wong GCL, Wales TE, Walensky LD. Inhibition of oligomeric BAX by an anti-apoptotic dimer. Cell 2025. PubMed
  • Deutsch-Williams RJ, Xie Y, Rabinowitz Z, Goemans M, Wirapati P, Vinegoni C, Carlson JC, Pittet M, Weissleder R. Targeting cancer-associated fibroblasts for real-time intraoperative tumor identification with a spray-on fluorescent probe. Sci Adv 2025; 11:eaeb5810. PubMed
  • Della Volpe L, Lee AJ, Antoszewski M, Deik AA, Safina KR, Gao T, Guo CJ, Ye T, Lyu P, Martin-Rufino JD, Castano N, Good J, Molina-Aponte Y, Zhao J, Clish CB, van Galen P, Sankaran VG. Inhibiting ferroptosis enhances ex vivo expansion of human haematopoietic stem cells. Nat Cell Biol 2025. PubMed
  • Wang C, Du M, Kim H, Nguyen LH, Wang QL, Drew DA, Leeming ER, Khandpur N, Sun Q, Zong X, Gweon TG, Ogino S, Ng K, Berry S, Giovannucci EL, Song M, Cao Y, Chan AT. Ultraprocessed Food Consumption and Risk of Early-Onset Colorectal Cancer Precursors Among Women. JAMA Oncol 2025. PubMed
  • Ruff KM, King MR, Ying AW, Liu V, Pant A, Lieberman WE, Shinn MK, Su X, Kadoch C, Pappu RV. Molecular grammars of predicted intrinsically disordered regions that span the human proteome. Cell 2025. PubMed
  • Xu EJK, Smith BE, Conce Alberto WD, Walsh MJ, Lim B, Hoffman MT, Qiang L, Barreiro A, Finburgh EN, Dong J, Garmilla A, Zhao QH, Perez CR, Gaglione SA, Dobson CS, Dougan M, Dougan SK, Birnbaum ME. Peptide-MHC-targeted retroviruses enable in vivo expansion and gene delivery to tumor-specific T cells. Sci Adv 2025; 11:eadv2331. PubMed
  • Palma M, Chaufan M, Breuer CB, Müller S, Sabatier M, Fraser CS, Szylo KJ, Yavari M, Carmona A, Kaur M, Melo LMN, Cansiz F, Monge-Lorenzo J, Flores M, Mishima E, Nakamura T, Proneth B, Labrado M, Liang Y, Cayting N, Zheng L, Cañeque T, Colombeau L, Wahida A, Friedmann Angeli JP, Tasdogan A, Hui S, Rodriguez R, Conrad M, Reticker-Flynn NE, Ubellacker JM. Lymph node environment drives FSP1 targetability in metastasizing melanoma. Nature 2025. PubMed
  • Parsons A, Sauras Colón E, Manjunath M, Zhang H, Chen J, Spasic M, Koca B, Binboga Kurt B, Freedman RA, Mittendorf EA, Swarbrick A, van Galen P, McAllister SS. Cell populations in human breast cancers are molecularly and biologically distinct with age. Nat Aging 2025. PubMed
  • Jänne PA, Planchard D, Goto K, Smit EF, de Langen AJ, Goto Y, Ninomiya K, Kubo T, Pérol M, Felip E, Hayashi H, Nakagawa K, Shimizu J, Nagasaka M, Pereira K, Taguchi A, Ali A, Karnoub M, Yonemochi R, Leung D, Li BT. Trastuzumab Deruxtecan for ERBB2-Mutant Metastatic Non-Small Cell Lung Cancer With or Without Brain Metastases: A Secondary Analysis of Randomized Clinical Trials. JAMA Netw Open 2025; 8:e2543107. PubMed
  • Raman HS, Cronin AM, Huntington SF, Uno H, Brennan C, Hurley SL, Tidswell A, Kaufman RM, Lanahan SM, Johnson KS, Tulsky JA, Abel GA, Odejide OO. Perceived Value of Transfusion Access and Hospice Services Among Patients With Blood Cancers. JAMA Netw Open 2025; 8:e2541719. PubMed
  • Birocchi F, Almazan AJ, Parker A, Bouffard AA, Goncalves S, Kelly C, Frank J, Leick MB, Haradhvala NJ, Kagawa S, Getz G, Escobar G, Salas-Benito D, Mucci A, Berger TR, Maus MV. On-target off-tumor toxicity of claudin18.2-directed CAR-T cells in preclinical models. Nat Commun 2025; 16:9650. PubMed
  • Ding T, Wagner SJ, Song AH, Chen RJ, Lu MY, Zhang A, Vaidya AJ, Jaume G, Shaban M, Kim A, Williamson DFK, Robertson H, Chen B, Almagro-Pérez C, Doucet P, Sahai S, Chen C, Chen CS, Komura D, Kawabe A, Ochi M, Sato S, Yokose T, Miyagi Y, Ishikawa S, Gerber G, Peng T, Le LP, Mahmood F. A multimodal whole-slide foundation model for pathology. Nat Med 2025; 31:3749-3761. PubMed
  • Bi K, Kashima S, Camp SY, Meli K, Saad E, Titchen BM, Labaki C, Bakouny Z, Pimenta EM, Park J, Shannon E, Fu J, Xirenayi S, Horst J, Lum L, Ishizuka JJ, Choueiri TK, Braun DA, Van Allen EM. Myeloid cells mediate interferon-driven resistance to immunotherapy in advanced renal cell carcinoma. Immunity 2025. PubMed
  • Tolaney SM, Jiang Z, Zhang Q, Barroso-Sousa R, Park YH, Rimawi MF, Saura C, Schneeweiss A, Toi M, Chae YS, Kemal Y, Chaudhari M, Şendur MAN, Yamashita T, Casalnuovo M, Danso MA, Liu J, Shetty J, Herbolsheimer P, Loibl S, . Trastuzumab Deruxtecan plus Pertuzumab for HER2-Positive Metastatic Breast Cancer. N Engl J Med 2025. PubMed
  • Li B, Ouchi T, Liu J, Yang Y. Injury-induced niche factors Cxcl12 and Shh/Ihh coordinate suture stem cell activation during calvarial bone regeneration. Sci Signal 2025; 18:eadw7107. PubMed
  • Tesch ME, Zheng Y, Guzman-Arocho YD, Collins LC, Heng YJJ, Tayob N, Rosenberg SM, Ruddy KJ, Tamimi RM, Schapira L, Peppercorn J, Borges V, Come SE, Snow C, Winer E, Mittendorf EA, Partridge AH. Association of tumor-infiltrating lymphocyte subtypes with clinical characteristics and prognosis in young women with hormone receptor-positive breast cancer. Clin Cancer Res 2025. PubMed
  • St Laurent JD, Xu GD, Ying AW, Gokbayrak B, Patil A, Paulo JA, Cervantes KS, Chen S, Feng WW, Sankar A, Samé Guerra DD, Qi J, Neel DS, Hornick JL, Kolin DL, Gygi SP, Hunstman DG, Wang Y, Kadoch C. Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in dedifferentiated endometrial carcinomas. Nat Genet 2025. PubMed
  • Jänne PA, Planchard D, Kobayashi K, Yang JC, Liu Y, Valdiviezo N, Kim TM, Jiang L, Kagamu H, Yanagitani N, Wang J, Biswas B, Poltoratskiy A, Neron Y, Rojas C, Koubkova L, Escriu C, Ezeife DA, Mann H, Armenteros-Monterroso E, Rukazenkov Y, Lee CK, . Survival with Osimertinib plus Chemotherapy in -Mutated Advanced NSCLC. N Engl J Med 2025. PubMed
  • Ludin A, Stirtz GL, Tal A, Nirmal AJ, Pfaff KL, Manos M, Besson N, Eskndir N, Porter B, Jones SM, Faulkner HM, Gong Q, Liu S, Barrera I, Wu L, Pessoa Rodrigues C, Sahu A, Jerison E, Alessi JV, Ricciuti B, Richardson DS, Weiss JD, Moreau HM, Stanhope ME, Afeyan AB, Sefton J, McCall WD, Formato E, Yang S, Zhou Y, Hoytema van Konijnenburg DP, Cole HL, Cordova M, Deng L, Rajadhyaksha M, Quake SR, Awad MM, Chen F, Wucherpfennig KW, Sorger PK, Hodi FS, Rodig SJ, Murphy GF, Zon LI. CRATER tumor niches facilitate CD8 T cell engagement and correspond with immunotherapy success. Cell 2025. PubMed
  • Zhang Y, Bhosle A, Bae S, Eckenrode K, Huang X, Tang J, Lavrentovich D, Awad L, Hua J, Wang Y, Morgan XC, Li B, Krueger A, Garrett WS, Franzosa EA, Huttenhower C. Predicting functions of uncharacterized gene products from microbial communities. Nat Biotechnol 2025. PubMed
  • Nader-Marta G, Chu X, Mukhopadhyay S, Abramson VG, Brufsky A, Stringer-Reasor EM, Dent SF, Traina TA, Carey LA, Rimawi MF, Specht JM, Miller KD, Santa-Maria CA, Dasgupta T, Kurt BB, DeMeo M, Krop IE, Tung NM, Schnitt SJ, Tayob N, Mayer EL. Prognostic value of visually and computationally-assessed tumor-infiltrating lymphocytes in early-stage triple-negative breast cancer (TBCRC-030). Journal of the National Cancer Institute 2025. PubMed
  • Zhang H, Liu L, Zhang X, Chen P, Lang X, Feng J, Wang Y, Xie Y, Wang S, Xiao S, Li B. Circulating tumor DNA from blood and cerebrospinal fluid in DLBCL: simultaneous evaluation of mutations, IG rearrangement, and IG clonality. Br J Cancer 2025. PubMed
  • Ling AL, Gantchev J, Prabhu MC, Basu S, Ahn R, D'Souza A, Masud N, Ball A, Nikas O, Villa GR, Regan MS, Baquer G, Ayoub G, Whittaker CA, Abou-Mrad Z, Santos A, Couturier CP, Elharouni D, Vogelzang J, Yu KKH, Chen H, He Z, Jiang W, Lucas CH, Sax HE, Lang FF, Puduvalli VK, Tabar V, W Brennan C, Boire A, Holdhoff M, Bettegowda C, Cima M, Solomon IH, Yuan Y, Tak PP, , Sharma P, White FM, Ligon KL, Agar NYR, Reardon DA, Oliveira G, Chiocca EA. Serial multiomics uncovers anti-glioblastoma responses not evident by routine clinical analyses. Sci Transl Med 2025; 17:eadv2881. PubMed
  • Wang Z, Li Z, Högström J, Inuzuka H, Jing R, Yan P, Hou T, Qi Y, Huang D, Wang J, Wu T, Shi X, Liu B, Muranen T, Zhang D, Wei W. Dual membrane receptor degradation via folate receptor targeting chimera. Nat Commun 2025; 16:8804. PubMed
  • Zhou C, Zhang M, Murray J, Paulo J, Gygi S, Shao S, Whitman M, Keller T. GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling. Science 2025; 390:eads8728. PubMed
  • Pradhan P, Iyer HS, Rebbeck TR. Geographic and Temporal Patterns of Screening for Breast, Cervical, and Colorectal Cancer in the US, 1997-2019. JAMA Netw Open 2025; 8:e2537905. PubMed
  • Manz CR, Nava-Coulter B, Voligny E, Gundersen DA, Wright AA. Correctional Health and Oncologist Perspectives on Strategies to Improve Cancer Care in US Prisons: A Qualitative Study. JAMA Netw Open 2025; 8:e2537640. PubMed
  • Manz CR, Nava-Coulter B, Voligny E, Gundersen DA, Wright AA. Barriers and Facilitators to Delivering Cancer Care in US Prisons. JAMA Netw Open 2025; 8:e2537646. PubMed
  • Park JC, Curti B, Butler M, Wehrenberg-Klee E, Elassal J, Tighe R, Battula S, Iodice G, Kaufman HL, Kirkwood JM. Interleukin-12 anchored drug conjugate (tolododekin alfa) in patients with advanced solid tumors: first-in-human Phase 1 trial. Nat Commun 2025; 16:8567. PubMed
  • Zhao J, Lin SY, Attias R, Mathews L, Engel C, Larghero G, Vremenko D, Kao TW, Lee TH, Wang YH, Tsai CC, Marostica E, Lo YC, Meredith D, Ligon KL, Arnaout O, Roetzer-Pejrimovsky T, Lin SC, Shih NN, Chaisuriya N, Cook DJ, Chiang JH, Liu CJ, Woehrer A, Golden JA, Nasrallah MP, Yu KH. Uncertainty-aware ensemble of foundation models differentiates glioblastoma from its mimics. Nat Commun 2025; 16:8341. PubMed
  • Yapp C, Nirmal AJ, Zhou F, Wong AYH, Tefft JB, Lu YD, Shang Z, Maliga Z, Llopis PM, Murphy GF, Lian CG, Danuser G, Santagata S, Sorger PK. Highly multiplexed 3D profiling of cell states and immune niches in human tumors. Nat Methods 2025. PubMed
  • Knudsen NH, Escobar G, Korell F, Kienka T, Nobrega C, Anderson S, Cheng AY, Zschummel M, Armstrong A, Bouffard A, Kann MC, Goncalves S, Pope HW, Pezeshki M, Rojas A, Suermondt JSMT, Phillips M, Berger TR, Park S, Salas-Benito D, Darnell EP, Birocchi F, Leick MB, Larson RC, Doench JG, Sen D, Yates KB, Manguso RT, Maus MV. In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma. Nature 2025. PubMed
  • Steinicke TL, Benfatto S, Capilla-Guerra MR, Monteleone AB, Young JH, Shankar S, Michaels PD, Tsai HK, Good JD, Kreso A, van Galen P, Schliemann C, Chen EC, Griffin GK, Hovestadt V. Rapid epigenomic classification of acute leukemia. Nat Genet 2025. PubMed
  • Xiao H, Ordonez M, Fink EC, Covington TA, Woldemichael HB, Chen J, Jain MS, Rohatgi MH, Wei SM, Burger N, Sharif MA, Jan J, Wang Y, Petrocelli JJ, Blackmore K, Smythers AL, Zhang B, Gilbert M, Cheong H, Khetarpal SA, Smith A, Bogoslavski D, Lei Y, Vaites LP, McAllister FE, Van Bruggen N, Donovan KA, Huttlin EL, Mills EL, Fischer ES, Chouchani ET. Covariation MS uncovers a protein that controls cysteine catabolism. Nature 2025. PubMed
  • Mayerhofer C, Li D, Kristiansen T, Mayerhofer E, Sharda A, Schiroli G, Gustafsson K, He L, Mazzola M, Keyes S, Kiem A, Crompton E, Xu Y, Korm S, Dou Z, Vidoudez C, Miller PG, van Gastel N, Graubert TA, Scadden DT. OGFOD1 enables AML chemo- and nutrient stress resistance by regulating protein synthesis. Cell Metab 2025. PubMed
  • Abou Haidar E, Prabhakar S, Geffrey AL, Mahamdeh M, Tomeh T, Breyne K, Roumieh E, Gurevich M, Soberman RJ, Wojtkiewicz GR, Chen JW, Han JS, Stemmer-Rachamimov A, Breakefield XO. AAV hamartin gene therapy in a stochastic, cerebral mouse model of tuberous sclerosis type 1. Mol Ther Methods Clin Dev 2025; 33:101556. PubMed
  • Savchuk S, Gentry KM, Wang W, Carleton E, Biagi-Junior CAO, Luthria K, Yalçın B, Ni L, Farnsworth HC, Davis RA, Drexler R, Melms JC, Liu Y, Acosta-Alvarez L, Hartmann GG, Pavarino EC, LaBelle J, Woo PJ, Toland AM, Qu F, Kim YS, Filbin MG, Krasnow MA, Ligon KL, Izar B, Sage J, Sabatini BL, Monje M, Venkatesh HS. Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis. Nature 2025. PubMed
  • Guo R, Sun Y, Lim MY, Shah H, Paulo JA, Ahmed RA, Li W, Zhang Y, Yang H, Wang LW, Strebinger D, Smith NA, Li M, Leong MML, Lutchenkov M, Liang JH, Li Z, Wang Y, Puri R, Melnick A, Green MR, Asara JM, Papathanassiu AE, Wesemann DR, Gygi SP, Mootha VK, Gewurz BE. Multi-omic analysis reveals a key BCAT1 role in mTOR activation by B-cell receptor and TLR9. J Clin Invest 2025. PubMed
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