Research Abstract
My professional goal is to discover clinically useful diagnostic markers and therapeutic targets in sarcoma, conducting rigorous translational research. As a physician-scientist I contribute my expertise in histopathology, molecular pathology, and genetics to the Dana-Farber/Brigham and Women’s Hospital sarcoma translational research program. In collaboration with the Broad Institute, I apply a high-throughput functional genomics platform to the study of representative sarcoma models. This work was the core of my PhD thesis dissertation, a published work for which we developed novel biocomputational approaches. This work received several academic awards and was expanded in my postdoctoral research studies, through which I developed substantial expertise in large-scale sarcoma cell culture, sarcoma in vitro studies including drug response and functional interventions, and computational analysis of large datasets. I also completed a Clinical Molecular Genetics Fellowship and assumed clinical responsibilities for sarcoma molecular diagnostics at Brigham and Women’s Hospital, including NGS-based cancer gene panel and circulating cfDNA interpretation that have been my main clinical focus over the last 3 years. I devote my clinical efforts solely to molecular diagnostics of GIST and other sarcomas and solid tumors. This role is the natural extension of my background in surgical pathology, and will benefit from my expertise in sarcoma morphology, immunohistochemistry, and a deep understanding of sarcoma genetics, sarcoma biology and clinicopathological features.
