The major objective of the research in my laboratories is the development of radionuclide carrier systems suitable for the specific delivery of diagnostic and therapeutic radioactive moieties to cancerous cells. The goal is to maximize the effectiveness of radiotherapeutic agents while minimizing their toxicity to normal tissues. We have synthesized proprietary radiolabeled thymidine analogs (19 US/International issued patents) and documented their radioimaging and radiotherapeutic potential in tumor-bearing animals. These results represent promising observations on a novel approach to cancer treatment with unsealed radioactive sources. Pharmacokinetics studies in cancer patients (brain, colorectal, breast, bladder) have shown the approach to be equally effective. More recently, we developed a novel proprietary technology (Enzyme-Mediated Cancer Imaging and Therapy, 7 US/International issued patents) that aim to irreversibly entrap and concentrate diagnostic and therapeutic radionuclides within solid tumors. When labeled with gamma or positron-emitting radionuclides, these molecules enable imaging (SPECT and PET) of solid tumors and their metastases. When labeled with energetic electron- or alpha-particles emitters, these prodrugs deposit therapeutic doses within solid tumors (technology licensed by OncoTherapeutica, Inc.).
Most recently, we developed novel proprietary noninvasive Immuno-Genomics blood (or other bodily fluid) based cancer (and other disease) detection assays (38 issued patents and >100 US and International pending patents). Using the SNEP (Subtraction Normalized Expressions of Phagocytes) Technology, we are able to identify cancer-specific genomic signatures in tumor-bearing mice, cancer patients (e.g., prostate, lung), and patients with other indications (e.g., Alzheimer’s, Cardiac Artery Disease, Rheumatoid Arthritis, Diabetes). The results of recent ongoing studies have confirmed the capability of the SNEP blood assay in identifying patients with aggressive prostate cancer (high risk) and those with very low risk of developing the disease (technology licensed by OncoCell MDx, Inc.).