My laboratory studies hematopoietic stem and progenitor cell biology and leukemia. We are interested in genetic and epigenetic alterations that result in aberrant signaling, altered chromatin state, or functionally-relevant changes to the transcriptome in leukemia. Our goal is to characterize the abnormal biology of transformed blood cells to develop novel therapeutic strategies. We study acute myeloid leukemia (AML), acute lymphoid leukemia (ALL), and blastic plasmacytoid dendritic cell neoplasm (BPDCN). We also are interested in sex bias in cancer genomes and how this translates to differences in incidence of malignancy and outcomes during therapy. Finally, we study resistance to novel leukemia therapies, including in leukemia stem cells, by genomic characterization (DNA and RNA sequencing, including single-cell approaches) of samples from patients before and at the time of progression after specific treatments. We have translated lab discoveries to new combinations that overcome targeted therapy resistance, and we now lead several phase 1-2 trials to test these strategies in patients with blood cancer.