Photo of Bob Carter, MD, PhD

Bob Carter, MD, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-8583

Photo of Bob Carter, MD, PhD

Massachusetts General Hospital
Phone: (617) 726-8583

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Bob Carter, MD, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Neurosurgery, Harvard Medical School
  • Chief of Neurosurgery, Neurosurgery, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Dr. Carter's research is focused on the analysis of extracellular vesicles (EVs) as potential biomarkers for glioma. Dr. Carter is Professor and Chief of Neurosurgery at the Massachusetts General Hospital.  I specialize in intracranial surgery including benign and malignant brain tumors and metastatic brain lesions. My laboratory leads a multi-institutional collaborative effort to clinically validate exRNA biomarkers, including those present in EVs. We also study the role of chimeric T-cell receptors as therapeutics for glioma.

Publications from Harvard Catalyst Profiles

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  • Schupper AJ, Baron RB, Cheung W, Rodriguez J, Kalkanis SN, Chohan MO, Andersen BJ, Chamoun R, Nahed BV, Zacharia BE, Kennedy J, Moulding HD, Zucker L, Chicoine MR, Olson JJ, Jensen RL, Sherman JH, Zhang X, Price G, Fowkes M, Germano IM, Carter BS, Hadjipanayis CG, Yong RL. 5-Aminolevulinic acid for enhanced surgical visualization of high-grade gliomas: a prospective, multicenter study. J Neurosurg 2021. PubMed
  • Khalafallah AM, Rakovec M, Bettegowda C, Jackson CM, Gallia GL, Weingart JD, Lim M, Esquenazi Y, Zacharia BE, Goldschmidt E, Ziu M, Ivan ME, Venteicher AS, Nduom EK, Mamelak AN, Chu RM, Yu JS, Sheehan JP, Nahed BV, Carter BS, Berger MS, Sawaya R, Mukherjee D. A Crowdsourced Consensus on Supratotal Resection Versus Gross Total Resection for Anatomically Distinct Primary Glioblastoma. Neurosurgery 2021. PubMed
  • Dhawan S, Venteicher AS, Butler WE, Carter BS, Chen CC. Clinical outcomes as a function of the number of samples taken during stereotactic needle biopsies: a meta-analysis. J. Neurooncol. 2021. PubMed
  • Park J, Park JS, Huang CH, Jo A, Cook K, Wang R, Lin HY, Van Deun J, Li H, Min J, Wang L, Yoon G, Carter BS, Balaj L, Choi GS, Castro CM, Weissleder R, Lee H. An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma. Nat Biomed Eng 2021; 5:678-689. PubMed
  • Simon MV, Curry WT, Jones PS, Cahill DP, Carter BS, Rapalino O, Malik AN, Nahed BV. Intraoperative thalamocortical tract monitoring via direct cortical recordings during craniotomy. Clin Neurophysiol 2021; 132:1416-1432. PubMed
  • Gupta M, Burns E, Georgantas NZ, Thierauf J, Nayyar N, Gordon A, Jones S, Pisapia M, Sun Y, Burns RP, Velarde JK, Jordan JT, Frigault MJ, Nahed BV, Jones PS, Barker FG, Curry W, Gupta R, Batchelor TT, Romero J, Brastianos P, Marble H, Martinez-Lage M, Tateishi K, Lennerz JK, Dietrich J, Cahill D, Carter B, Shankar GM. A Rapid Genotyping Panel for Detection of Primary Central Nervous System Lymphoma. Blood 2021. PubMed
  • Kang KM, Muralidharan K, Yekula A, Small JL, Rosh ZS, Jones PS, Carter BS, Balaj L. Blood-Based Detection of BRAF V600E in Gliomas and Brain Tumor Metastasis. Cancers (Basel) 2021. PubMed
  • Muhlestein WE, Monsour MA, Friedman GN, Zinzuwadia A, Zachariah MA, Coumans JV, Carter BS, Chambless LB. Predicting Discharge Disposition Following Meningioma Resection Using a Multi-Institutional Natural Language Processing Model. Neurosurgery 2021. PubMed
  • Muralidharan K, Yekula A, Small JL, Rosh ZS, Kang KM, Wang L, Lau S, Zhang H, Lee H, Bettegowda C, Chicoine MR, Kalkanis SN, Shankar GM, Nahed BV, Curry WT, Jones PS, Cahill DP, Balaj L, Carter BS. Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas. Clin Cancer Res 2021; 27:169-178. PubMed
  • Maas SLN, van Solinge TS, Schnoor R, Yekula A, Senders JT, de Vrij J, Robe P, Carter BS, Balaj L, Arkesteijn GJA, Nolte-'t Hoen ENM, Broekman MLD. Orally Administered 5-aminolevulinic Acid for Isolation and Characterization of Circulating Tumor-Derived Extracellular Vesicles in Glioblastoma Patients. Cancers (Basel) 2020. PubMed
  • Steed TC, Treiber JM, Taha B, Engin HB, Carter H, Patel KS, Dale AM, Carter BS, Chen CC. Glioblastomas located in proximity to the subventricular zone (SVZ) exhibited enrichment of gene expression profiles associated with the cancer stem cell state. J. Neurooncol. 2020. PubMed
  • Yekula A, Muralidharan K, Rosh ZS, Youngkin AE, Kang KM, Balaj L, Carter BS. Liquid Biopsy Strategies to Distinguish Progression from Pseudoprogression and Radiation Necrosis in Glioblastomas. Adv Biosyst 2020. PubMed
  • Wang L, Yekula A, Muralidharan K, Small JL, Rosh ZS, Kang KM, Carter BS, Balaj L. Novel Gene Fusions in Glioblastoma Tumor Tissue and Matched Patient Plasma. Cancers (Basel) 2020. PubMed
  • Ramakrishnan V, Xu B, Akers J, Nguyen T, Ma J, Dhawan S, Ning J, Mao Y, Hua W, Kokkoli E, Furnari F, Carter BS, Chen CC. Radiation-induced extracellular vesicle (EV) release of miR-603 promotes IGF1-mediated stem cell state in glioblastomas. EBioMedicine 2020; 55:102736. PubMed
  • Ricklefs FL, Maire CL, Matschke J, Dührsen L, Sauvigny T, Holz M, Kolbe K, Peine S, Herold-Mende C, Carter B, Chiocca EA, Lawler SE, Westphal M, Lamszus K. FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles. Int J Mol Sci 2020. PubMed
  • Yekula A, Muralidharan K, Kang KM, Wang L, Balaj L, Carter BS. From laboratory to clinic: Translation of extracellular vesicle based cancer biomarkers. Methods 2020. PubMed
  • Choi BD, Yu X, Castano AP, Darr H, Henderson DB, Bouffard AA, Larson RC, Scarfò I, Bailey SR, Gerhard GM, Frigault MJ, Leick MB, Schmidts A, Sagert JG, Curry WT, Carter BS, Maus MV. CRISPR-Cas9 disruption of PD-1 enhances activity of universal EGFRvIII CAR T cells in a preclinical model of human glioblastoma. J Immunother Cancer 2019; 7:304. PubMed
  • Jones PS, Yekula A, Lansbury E, Small JL, Ayinon C, Mordecai S, Hochberg FH, Tigges J, Delcuze B, Charest A, Ghiran I, Balaj L, Carter BS. Characterization of plasma-derived protoporphyrin-IX-positive extracellular vesicles following 5-ALA use in patients with malignant glioma. EBioMedicine 2019; 48:23-35. PubMed
  • Choi BD, Yu X, Castano AP, Bouffard AA, Schmidts A, Larson RC, Bailey SR, Boroughs AC, Frigault MJ, Leick MB, Scarfò I, Cetrulo CL, Demehri S, Nahed BV, Cahill DP, Wakimoto H, Curry WT, Carter BS, Maus MV. CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity. Nat Biotechnol 2019; 37:1049-1058. PubMed
  • Lewis J, Alattar AA, Akers J, Carter BS, Heller M, Chen CC. A Pilot Proof-Of-Principle Analysis Demonstrating Dielectrophoresis (DEP) as a Glioblastoma Biomarker Platform. Sci Rep 2019; 9:10279. PubMed
  • Roy S, Lin HY, Chou CY, Huang CH, Small J, Sadik N, Ayinon CM, Lansbury E, Cruz L, Yekula A, Jones PS, Balaj L, Carter BS. Navigating the Landscape of Tumor Extracellular Vesicle Heterogeneity. Int J Mol Sci 2019. PubMed
  • Choi BD, Lee DK, Yang JC, Ayinon CM, Lee CK, Maus D, Carter BS, Barker FG, Jones PS, Nahed BV, Cahill DP, See RB, Simon MV, Curry WT. Receptor tyrosine kinase gene amplification is predictive of intraoperative seizures during glioma resection with functional mapping. J Neurosurg 2019. PubMed
  • Yekula A, Yekula A, Muralidharan K, Kang K, Carter BS, Balaj L. Extracellular Vesicles in Glioblastoma Tumor Microenvironment. 2019; 10:3137. PubMed
  • Alattar AA, Carroll KT, Bryant AK, Hirshman B, Joshi R, Carter BS, Harismendy O, Chen CC. Prognostic importance of age, tumor location, and tumor grade in grade II astrocytomas: an integrated analysis of The Cancer Genome Atlas and the Surveillance, Epidemiology, and End Results database. World Neurosurg 2018. PubMed
  • Treiber JM, Steed TC, Brandel MG, Patel KS, Dale AM, Carter BS, Chen CC. Molecular physiology of contrast enhancement in glioblastomas: An analysis of The Cancer Imaging Archive (TCIA). J Clin Neurosci 2018. PubMed
  • Choi BD, Curry WT, Carter BS, Maus MV. Chimeric antigen receptor T-cell immunotherapy for glioblastoma: practical insights for neurosurgeons. Neurosurg Focus 2018; 44:E13. PubMed
  • Zachariah M, Oliveira-Costa JP, Carter B, Stott SL, Nahed BV. Blood-Based Biomarkers for the Diagnosis and Monitoring of Gliomas. 2018. PubMed
  • Patel KS, Dhawan S, Wang R, Carter BS, Chen JY, Chen CC. Post-operative imaging assessment of non-functioning pituitary adenomas. Acta Neurochir (Wien) 2018; 160:1029-1039. PubMed
  • Koga T, Li B, Figueroa JM, Ren B, Chen CC, Carter BS, Furnari FB. Mapping of genomic EGFRvIII deletions in glioblastoma: insight into rearrangement mechanisms and biomarker development. 2018. PubMed
  • Carroll KT, Lochte BC, Chen JY, Snyder VS, Carter BS, Chen CC. Intraoperative Magnetic Resonance Imaging-Guided Biopsy in the Diagnosis of Suprasellar Langerhans Cell Histiocytosis. World Neurosurg 2018; 112:6-13. PubMed
  • Ricklefs FL, Alayo Q, Krenzlin H, Mahmoud AB, Speranza MC, Nakashima H, Hayes JL, Lee K, Balaj L, Passaro C, Rooj AK, Krasemann S, Carter BS, Chen CC, Steed T, Treiber J, Rodig S, Yang K, Nakano I, Lee H, Weissleder R, Breakefield XO, Godlewski J, Westphal M, Lamszus K, Freeman GJ, Bronisz A, Lawler SE, Chiocca EA. Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles. Sci Adv 2018; 4:eaar2766. PubMed
  • Carroll KT, Bryant AK, Hirshman B, Alattar AA, Joshi R, Gabel B, Carter BS, Harismendy O, Vaida F, Chen CC. Interaction Between the Contributions of Tumor Location, Tumor Grade, and Patient Age to the Survival Benefit Associated with Gross Total Resection. World Neurosurg 2018; 111:e790-e798. PubMed
  • Kang KH, Schapira E, Niemierko A, Martinez-Lage M, Bussière MR, Yock TI, Loeffler JS, Butler WE, Carter BS, Shih HA. The role of proton beam therapy in central neurocytoma: A single-institution experience. 2018. PubMed
  • Steed TC, Treiber JM, Brandel MG, Patel KS, Dale AM, Carter BS, Chen CC. Quantification of glioblastoma mass effect by lateral ventricle displacement. Sci Rep 2018; 8:2827. PubMed
  • Santiago-Dieppa DR, Gonda DD, Cheung VJ, Steinberg JA, Carter BS, Chen CC. Extracellular Vesicles as a Platform for Glioma Therapeutic Development. Prog Neurol Surg 2018; 32:172-179. PubMed
  • Sahin A, Sanchez C, Bullain S, Waterman P, Weissleder R, Carter BS. Development of third generation anti-EGFRvIII chimeric T cells and EGFRvIII-expressing artificial antigen presenting cells for adoptive cell therapy for glioma. PLoS ONE 2018; 13:e0199414. PubMed
  • Patel KS, Carter BS, Chen CC. Role of Biopsies in the Management of Intracranial Gliomas. Prog Neurol Surg 2018; 30:232-243. PubMed
  • Adhikari B, Li J, Brandel MG, Futalan D, Akers J, Deming T, Chen CC, Carter BS. The use of TMZ embedded hydrogels for the treatment of orthotopic human glioma xenografts. J Clin Neurosci 2017; 45:288-292. PubMed
  • Figueroa JM, Carter BS. Detection of glioblastoma in biofluids. J Neurosurg 2017. PubMed
  • Figueroa JM, Skog J, Akers J, Li H, Komotar R, Jensen R, Ringel F, Yang I, Kalkanis S, Thompson R, LoGuidice L, Berghoff E, Parsa A, Liau L, Curry W, Cahill D, Bettegowda C, Lang FF, Chiocca EA, Henson J, Kim R, Breakefield X, Chen C, Messer K, Hochberg F, Carter BS. Detection of wild-type EGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients. 2017; 19:1494-1502. PubMed
  • Akers JC, Hua W, Li H, Ramakrishnan V, Yang Z, Quan K, Zhu W, Li J, Figueroa J, Hirshman BR, Miller B, Piccioni D, Ringel F, Komotar R, Messer K, Galasko DR, Hochberg F, Mao Y, Carter BS, Chen CC. A cerebrospinal fluid microRNA signature as biomarker for glioblastoma. 2017; 8:68769-68779. PubMed
  • Hirshman BR, Wilson BR, Ali MA, Schupper AJ, Proudfoot JA, Goetsch SJ, Carter BS, Sinclair G, Bartek J, Chiang V, Fogarty G, Hong A, Chen CC. Cumulative Intracranial Tumor Volume Augments the Prognostic Value of Diagnosis-Specific Graded Prognostic Assessment Model for Survival in Patients with Melanoma Cerebral Metastases. Neurosurgery 2017. PubMed
  • Brown JM, Mahan MA, Mandeville R, Carter BS. Establishing reconstructive neurosurgery as a subspecialty. Neurosurg Focus 2017; 43:E7. PubMed
  • Lau SK, Patel K, Kim T, Knipprath E, Kim GY, Cerviño LI, Lawson JD, Murphy KT, Sanghvi P, Carter BS, Chen CC. Clinical efficacy and safety of surface imaging guided radiosurgery (SIG-RS) in the treatment of benign skull base tumors. J. Neurooncol. 2017. PubMed
  • Tringale KR, Wilson BR, Hirshman B, Zhou T, Folsom D, Norman MA, Grant I, Chen CC, Carter BS. Psychiatric Disease Preceding Intracranial Tumor Diagnosis: Investigating the Association. Prim Care Companion CNS Disord 2016. PubMed
  • Hirshman BR, Jones LA, Carroll KT, Tang JA, Proudfoot JA, Carley KM, Carter BS, Chen CC. Coevolution of Peer-Reviewed Literature and Clinical Practice in High-Grade Glioma Resection. World Neurosurg 2016; 96:237-241. PubMed
  • Rennert RC, Santiago-Dieppa DR, Figueroa J, Sanai N, Carter BS. Future directions of operative neuro-oncology. J. Neurooncol. 2016; 130:377-382. PubMed
  • Ziu M, Dunn IF, Hess C, Fleseriu M, Bodach ME, Tumialan LM, Oyesiku NM, Patel KS, Wang R, Carter BS, Chen JY, Chen CC, Patil CG, Litvack Z, Zada G, Aghi MK. Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Posttreatment Follow-up Evaluation of Patients With Nonfunctioning Pituitary Adenomas. Neurosurgery 2016; 79:E541-3. PubMed
  • Chen CC, Carter BS, Wang R, Patel KS, Hess C, Bodach ME, Tumialan LM, Oyesiku NM, Patil CG, Litvack Z, Zada G, Aghi MK. Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Preoperative Imaging Assessment of Patients With Suspected Nonfunctioning Pituitary Adenomas. Neurosurgery 2016; 79:E524-6. PubMed
  • Skog J,Wurdinger T,van Rijn S,Meijer DH,Gainche L,Sena-Esteves M,Curry WT Jr,Carter BS,Krichevsky AM,Breakefield XO. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 2008; 10:1470-6. PubMed
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DF/HCC members that share similar concepts* with Bob Carter, MD, PhD but have yet to coauthor a publication with this researcher.

* Concepts are MeSH terms, automatically derived from member publications

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