My research focuses on regulatory and translational science, particularly with regards to the generation of meaningful preclinical and early phase clinical data to support the development of novel therapies and biomarkers. The major areas of focus include:
1) Bayesian adaptive clinical trial design- development of methods and designs to incorporate prior data and generate new information during clinical trials to support or refute biomarker/therapeutic hypotheses.
2) Biomarker development- analysis of clinically annotated molecular and imaging data to identify novel prognostic, predictive, and response biomarkers
3) Preclinical modeling- use of patient-derived brain tumor cell line and xenograft models for preclinical testing of radiation and systemic agents, target identification, and co-clinical trials