Photo of Clement Ma,  PhD

Clement Ma, PhD

Boston Children's Hospital

Boston Children's Hospital
Phone: (617) 632-1957


clement_ma@dfci.harvard.edu

Clement Ma, PhD

Boston Children's Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Pediatrics, Harvard Medical School
  • Lead Statistician, Hematology/Oncology, Boston Children's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Dr. Clement Ma is Assistant Professor of Pediatrics at Harvard Medical School, and Lead Biostatistician at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center. He completed his Ph.D. and postdoctoral fellowship in Biostatistics at the University of Michigan. Dr. Ma’s independent statistical research focuses on the design and conduct of Bayesian adaptive phase I clinical trials in pediatric oncology. His novel adaptive designs, which improve the trial’s accuracy and efficiency compared to traditional designs, have already been implemented in ongoing pediatric trials. As Lead Biostatistician, he provides statistical leadership in clinical research studies in pediatric oncology and hematology, with particular interest in the design and analysis of rare disease registries. He also serves as the study statistician in multiple active clinical trials in pediatric oncology, hematology, and other pediatric specialties.

Publications

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  • Marcus KL, Kao PC, Ma C, Wolfe J, DeCourcey DD. Symptoms and Suffering at End of Life for Children with Complex Chronic Conditions. J Pain Symptom Manage 2021. PubMed
  • Umaretiya PJ, Li A, McGovern A, Ma C, Wolfe J, Bona K. Race, ethnicity, and goal-concordance of end-of-life palliative care in pediatric oncology. Cancer 2021. PubMed
  • Gillani R, Seong BKA, Crowdis J, Conway JR, Dharia NV, Alimohamed S, Haas BJ, Han K, Park J, Dietlein F, He MX, Imamovic A, Ma C, Bassik MC, Boehm JS, Vazquez F, Gusev A, Liu D, Janeway KA, McFarland JM, Stegmaier K, Van Allen EM. Gene fusions create partner and collateral dependencies essential to cancer cell survival. Cancer Res 2021. PubMed
  • Zheng DJ, Li A, Ma C, Ribeiro KB, Diller L, Bona K, Marron JM. Socioeconomic disparities in survival after high-risk neuroblastoma treatment with modern therapy. Pediatr Blood Cancer 2021. PubMed
  • Shulman DS, Kiwinda LV, Edwards S, Clinton CM, Hunt S, Greenspan L, Lawler KD, Reaman G, Al-Sayegh H, Bona K, O'Neill AF, Shusterman S, Janeway KA, Place AE, Chi SN, Ma C, DuBois SG. Retrospective evaluation of single patient investigational new drug (IND) requests in pediatric oncology. Cancer Med 2021. PubMed
  • Ilcisin LA, Ma C, Janeway KA, DuBois SG, Shulman DS. Derivation and validation of risk groups in patients with osteosarcoma utilizing regression tree analysis. Pediatr Blood Cancer 2021; 68:e28834. PubMed
  • Ma C, Sridharan M, Al-Sayegh H, Li A, Guo D, Auclair M, Kuragayala V, Bandaru C, Milne D, Cruse H, Beaudoin R, Orechia J, Bickel J, London WB. Building a Harmonized Datamart by Integrating Cross-Institutional Systems of Clinical, Outcome, and Genomic Data: The Pediatric Patient Informatics Platform (). JCO Clin Cancer Inform 2021; 5:202-215. PubMed
  • Feraco AM, McCarthy SR, Revette AC, Stevens SE, Das PJ, Al-Sayegh H, Ma C, Tulsky JA, Wolfe J. Feasibility and acceptability of the "Day 100 Talk": An interdisciplinary communication intervention during the first six months of childhood cancer treatment. Cancer 2020. PubMed
  • Snaman JM, Helton G, Baker JN, Morris SE, Al-Sayegh H, Ma C, Wolfe J. Engaging Parents of Children Who Died from Cancer in Research on the Early Grief Experience. J Pain Symptom Manage 2020. PubMed
  • Nader JH, Neel DV, Shulman DS, Ma C, Bourgeois F, DuBois SG. Landscape of phase 1 clinical trials for minors with cancer in the United States. Pediatr Blood Cancer 2020. PubMed
  • Lim M, Shulman DS, Roberts H, Li A, Clymer J, Bona K, Al-Sayegh H, Ma C, DuBois SG. Off-label prescribing of targeted anticancer therapy at a large pediatric cancer center. Cancer Med 2020. PubMed
  • Feraco AM, Ananth P, Dussel V, Al-Sayegh H, Ma C, Rosenberg AR, Feudtner C, Wolfe J. Parent Perceptions of Team-Delivered Care for Children with Advanced Cancer: A report from the PediQUEST study. J Pain Symptom Manage 2020. PubMed
  • Greenzang KA, Al-Sayegh H, Ma C, Najafzadeh M, Wittenberg E, Mack JW. Parental Considerations Regarding Cure and Late Effects for Children With Cancer. Pediatrics 2020. PubMed
  • Neel DV, Shulman DS, Ma C, Bourgeois F, DuBois SG. Sponsorship of oncology clinical trials in the United States according to age of eligibility. Cancer Med 2020. PubMed
  • Chau NG, Ma C, Danga K, Al-Sayegh H, Nardi V, Barrette R, Lathan CS, DuBois SG, Haddad RI, Shapiro GI, Sallan SE, Dhar A, Nelson JJ, French CA. An Anatomical Site and Genetic-Based Prognostic Model for Patients With Nuclear Protein in Testis (NUT) Midline Carcinoma: Analysis of 124 Patients. JNCI Cancer Spectr 2020; 4:pkz094. PubMed
  • Campbell K, Ma C, DuBois SG. New approaches to therapeutic drug development for childhood cancers. Curr Opin Pediatr 2019. PubMed
  • Li H, Natarajan A, Ezike J, Barrasa MI, Le Y, Feder ZA, Yang H, Ma C, Markoulaki S, Lodish HF. Rate of Progression through a Continuum of Transit-Amplifying Progenitor Cell States Regulates Blood Cell Production. Dev Cell 2020; 49:118-129.e7. PubMed
  • Schoettler M, Lehmann L, Li A, Ma C, Duncan C. Thrombotic Microangiopathy Following Pediatric Autologous Hematopoietic Cell Transplantation: A Report of Significant End-Organ Dysfunction in Eculizumab-Treated Survivors. Biol Blood Marrow Transplant 2020; 25:e163-e168. PubMed
  • Ilowite MF, Al-Sayegh H, Ma C, Dussel V, Rosenberg AR, Feudtner C, Kang TI, Wolfe J, Bona K. The Relationship Between Household Income and Patient-Reported Symptom Distress and Quality of Life in Children With Advanced Cancer: A Report From the PediQUEST Study. Cancer 2018. PubMed
  • Zheng DJ, Shyr D, Ma C, Muriel AC, Wolfe J, Bona K. Feasibility of systematic poverty screening in a pediatric oncology referral center. Pediatr Blood Cancer 2018. PubMed
  • Robertson FC, Ullrich NJ, Manley PE, Al-Sayegh H, Ma C, Goumnerova LC. The Impact of Intraoperative Electrocorticography on Seizure Outcome After Resection of Pediatric Brain Tumors: A Cohort Study. Neurosurgery 2018. PubMed
  • Ananth P, Ma C, Al-Sayegh H, Kroon L, Klein V, Wharton C, Hallez E, Braun I, Michelson K, Rosenberg AR, London W, Wolfe J. Provider Perspectives on Use of Medical Marijuana in Children With Cancer. Pediatrics 2018. PubMed
  • De Vita S, Li Y, Harris CE, McGuinness MK, Ma C, Williams DA. The gp130 Cytokine IL-11 Regulates Engraftment of Vav1-/- Hematopoietic Stem and Progenitor Cells in Lethally Irradiated Recipients. Stem Cells 2017. PubMed
  • Bilodeau M, Ma C, Al-Sayegh H, Wolfe J, Bona K. Household material hardship in families of children post-chemotherapy. Pediatr Blood Cancer 2017. PubMed
  • Marcus KL, Balkin EM, Al-Sayegh H, Guslits E, Blume ED, Ma C, Wolfe J. Patterns and Outcomes of Care in Children with Advanced Heart Disease Receiving Palliative Care Consultation. J Pain Symptom Manage 2017. PubMed
  • Ananth P, Monsereenusorn C, Ma C, Al-Sayegh H, Wolfe J, Rodriguez-Galindo C. Influence of early phase clinical trial enrollment on patterns of end-of-life care for children with advanced cancer. Pediatr Blood Cancer 2017. PubMed
  • Marinoff AE, Ma C, Guo D, Snuderl M, Wright KD, Manley PE, Al-Sayegh H, Sinai CE, Ullrich NJ, Marcus K, Haas-Kogan D, Goumnerova L, London WB, Kieran MW, Chi SN, Fangusaro J, Bandopadhayay P. Rethinking childhood ependymoma: a retrospective, multi-center analysis reveals poor long-term overall survival. J. Neurooncol. 2017. PubMed
  • Kamihara J, Ma C, Fuentes Alabi SL, Garrido C, Frazier AL, Rodriguez-Galindo C, Orjuela MA. Socioeconomic status and global variations in the incidence of neuroblastoma: call for support of population-based cancer registries in low-middle-income countries. Pediatr Blood Cancer 2016; 64:321-323. PubMed
  • Weinacht KG, Charbonnier LM, Alroqi F, Plant A, Qiao Q, Wu H, Ma C, Torgerson TR, Rosenzweig SD, Fleisher TA, Notarangelo LD, Hanson IC, Forbes LR, Chatila TA. Ruxolitinib reverses dysregulated T helper cell responses and controls autoimmunity caused by a novel signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation. J Allergy Clin Immunol 2017. PubMed
  • Tubman VN, Marshall R, Jallah W, Guo D, Ma C, Ohene-Frempong K, London WB, Heeney MM. Newborn Screening for Sickle Cell Disease in Liberia: A Pilot Study. Pediatr Blood Cancer 2016; 63:671-6. PubMed
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