Photo of Connie Lehman,  MD, PhD

Connie Lehman, MD, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 724-3483


clehman@mgh.harvard.edu

Connie Lehman, MD, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Radiology, Harvard Medical School
  • Chief of Breast Imaging, radiology, Massachusetts General Hospital
  • Co-director of AVON Breast Center, Radiology, Massachusetts General Hospital
  • Director, Breast Imaging Research Center, Radiology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

As a change agent, innovator, and pioneer in the domain of Artificial Intelligence implementation in clinical medical practice, my work applies artificial intelligence and advanced methods of deep learning to improve breast cancer detection, diagnosis and treatment. In collaboration with colleagues at MIT, my lab and clinical center is applying AI to deliver higher quality health outcomes at lower costs for the full diversity of patients at risk for and with cancer. This is a continuation of my career-long commitment to expand access for all patients globally to highest quality, patient-centered, affordable care.

Publications

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  • Kang J, Thompson RF, Aneja S, Lehman C, Trister A, Zou J, Obcemea C, El Naqa I. NCI Workshop on Artificial Intelligence in Radiation Oncology: Training the Next Generation. 2020. PubMed
  • Panigrahi B, Miles RC, Chou SS, Brackett DG, Sohn YJ, Lehman C. Rare case of invasive lobular carcinoma in a male. Radiol Case Rep 2020; 15:727-729. PubMed
  • Bahl M, Mercaldo S, Dang PA, McCarthy AM, Lowry KP, Lehman CD. Breast Cancer Screening with Digital Breast Tomosynthesis: Are Initial Benefits Sustained? Radiology 2020; 295:529-539. PubMed
  • Kuhl CK, Lehman C, Bedrosian I. Imaging in Locoregional Management of Breast Cancer. J Clin Oncol 2020. PubMed
  • Oseni TO, Smith BL, Lehman CD, Vijapura CA, Pinnamaneni N, Bahl M. Do Eligibility Criteria for Ductal Carcinoma In Situ (DCIS) Active Surveillance Trials Identify Patients at Low Risk for Upgrade to Invasive Carcinoma? Ann Surg Oncol 2020. PubMed
  • Isakoff SJ, Lehman CD, Shannon KM, Basnet KM. Case 7-2020: A 52-Year-Old Man with a Mass in the Left Breast. N Engl J Med 2020; 382:856-864. PubMed
  • Dontchos BN, Yala A, Barzilay R, Xiang J, Lehman CD. External Validation of a Deep Learning Model for Predicting Mammographic Breast Density in Routine Clinical Practice. Acad Radiol 2020. PubMed
  • Narayan AK, Lehman CD. Mammography Screening Guideline Controversies: Opportunities to Improve Patient Engagement in Screening. J Am Coll Radiol 2020. PubMed
  • Debruhl ND, Lee SJ, Mahoney MC, Hanna L, Tuite C, Gatsonis CA, Lehman C. MRI Evaluation of the Contralateral Breast in Women with Recently Diagnosed Breast Cancer: 2-Year Follow-up. J Breast Imaging 2020; 2:50-55. PubMed
  • Wang GX, Narayan AK, Park ER, Lehman CD, Gorenstein JT, Flores EJ. Screening Mammography Visits as Opportunities to Engage Smokers With Tobacco Cessation Services and Lung Cancer Screening. J Am Coll Radiol 2020. PubMed
  • Lopez D, Miles RC, Flores EJ, Lehman CD, Narayan AK. Breast Cancer Screening in Puerto Rico and Other US Territories: Findings from the 2016 Behavioral Risk Factor Surveillance System Survey. J Health Care Poor Underserved 2020; 31:340-352. PubMed
  • Miles RC, Choi P, Baird GL, Dibble EH, Lamb L, Garg M, Lehman C. Will the Effect of New Federal Breast Density Legislation Be Diminished by Currently Available Online Patient Educational Materials? Acad Radiol 2019. PubMed
  • Edmonds CE, Lamb LR, Mercaldo SF, Sippo DA, Burk KS, Lehman CD. Frequency and Cancer Yield of BI-RADS Category 3 Lesions Detected at High-Risk Screening Breast MRI. AJR Am J Roentgenol 2019. PubMed
  • Lamb LR, Lehman CD, Oseni TO, Bahl M. Ductal Carcinoma In Situ (DCIS) at Breast MRI: Predictors of Upgrade to Invasive Carcinoma. Acad Radiol 2019. PubMed
  • Yala A, Schuster T, Miles R, Barzilay R, Lehman C. A Deep Learning Model to Triage Screening Mammograms: A Simulation Study. Radiology 2019; 293:38-46. PubMed
  • Dontchos BN, Rahbar H, Partridge SC, Lehman CD, DeMartini WB. Influence of Menstrual Cycle Timing on Screening Breast MRI Background Parenchymal Enhancement and Diagnostic Performance in Premenopausal Women. J Breast Imaging 2019; 1:205-211. PubMed
  • Miles RC, Lehman CD, Mercaldo SF, Tamimi RM, Dontchos BN, Narayan AK. Obesity and breast cancer screening: Cross-sectional survey results from the behavioral risk factor surveillance system. Cancer 2019. PubMed
  • Sippo DA, Rutledge GM, Mercaldo SF, Burk KS, Edmonds CE, Dang PA, Lehman CD. Impact of Background Parenchymal Enhancement on Diagnostic Performance in Screening Breast MRI. Acad Radiol 2019. PubMed
  • Lam DL, Smith J, Partridge SC, Kim A, Javid SH, Hippe DS, Lehman CD, Lee JM, Rahbar H. The Impact of Preoperative Breast MRI on Surgical Management of Women with Newly Diagnosed Ductal Carcinoma In Situ. Acad Radiol 2019. PubMed
  • Flores EJ, López D, Miles RC, Glover M, Lehman CD, Harvey HB, Narayan AK. Impact of Primary Care Physician Interaction on Longitudinal Adherence to Screening Mammography Across Different Racial/Ethnic Groups. J Am Coll Radiol 2019; 16:908-914. PubMed
  • Yala A, Lehman C, Schuster T, Portnoi T, Barzilay R. A Deep Learning Mammography-based Model for Improved Breast Cancer Risk Prediction. Radiology 2019; 292:60-66. PubMed
  • Miles RC, Lehman C, Warner E, Tuttle A, Saksena M. Patient-Reported Breast Density Awareness and Knowledge after Breast Density Legislation Passage. Acad Radiol 2019; 26:726-731. PubMed
  • Dontchos BN, Narayan AK, Seidler M, Mercaldo SF, Miles RC, Ebert E, Lehman CD. Impact of a Same-Day Breast Biopsy Program on Disparities in Time to Biopsy. J Am Coll Radiol 2019. PubMed
  • Choudhery S, Chou SS, Chang K, Kalpathy-Cramer J, Lehman CD. Kinetic Analysis of Lesions Identified on a Rapid Abridged Multiphase (RAMP) Breast MRI Protocol. Acad Radiol 2019. PubMed
  • López D, Flores EJ, Miles RC, Wang G, Glover M, Shepard JA, Lehman CD, Narayan AK. Assessing Eligibility for Lung Cancer Screening Among Women Undergoing Screening Mammography: Cross-Sectional Survey Results From the National Health Interview Survey. J Am Coll Radiol 2019. PubMed
  • Lee JM, Arao RF, Sprague BL, Kerlikowske K, Lehman CD, Smith RA, Henderson LM, Rauscher GH, Miglioretti DL. Performance of Screening Ultrasonography as an Adjunct to Screening Mammography in Women Across the Spectrum of Breast Cancer Risk. JAMA Intern Med 2019; 179:658-667. PubMed
  • Bahl M, Lehman CD. Breast Cancer Screening Using Digital Breast Tomosynthesis: Not All Mammography Is Equal. JAMA Oncol 2019; 5:642-643. PubMed
  • Arasu VA, Miglioretti DL, Sprague BL, Alsheik NH, Buist DSM, Henderson LM, Herschorn SD, Lee JM, Onega T, Rauscher GH, Wernli KJ, Lehman CD, Kerlikowske K. Population-Based Assessment of the Association Between Magnetic Resonance Imaging Background Parenchymal Enhancement and Future Primary Breast Cancer Risk. J Clin Oncol 2019; 37:954-963. PubMed
  • Narayan AK, Lopez DB, Miles RC, Dontchos B, Flores EJ, Glover M, Lehman CD. Implementation of an Intimate Partner Violence Screening Assessment and Referral System in an Academic Women's Imaging Department. J Am Coll Radiol 2019; 16:631-634. PubMed
  • Portnoi T, Yala A, Schuster T, Barzilay R, Dontchos B, Lamb L, Lehman C. Deep Learning Model to Assess Cancer Risk on the Basis of a Breast MR Image Alone. AJR Am J Roentgenol 2019. PubMed
  • Sippo DA, Rutledge GM, Burk KS, Mercaldo SF, Dontchos BN, Edmonds CE, Lehman CD. Effect of Background Parenchymal Enhancement on Cancer Risk Across Different High-Risk Patient Populations Undergoing Screening Breast MRI. AJR Am J Roentgenol 2019. PubMed
  • Rahbar H, Zhang Z, Chenevert TL, Romanoff J, Kitsch AE, Hanna LG, Harvey SM, Moy L, DeMartini WB, Dogan B, Yang WT, Wang LC, Joe BN, Oh KY, Neal CH, McDonald ES, Schnall MD, Lehman CD, Comstock CE, Partridge SC. Utility of Diffusion-weighted Imaging to Decrease Unnecessary Biopsies Prompted by Breast MRI: A Trial of the ECOG-ACRIN Cancer Research Group (A6702). Clin Cancer Res 2019; 25:1756-1765. PubMed
  • Cui C, Chou SS, Brattain L, Lehman CD, Samir AE. Data Engineering for Machine Learning in Women's Imaging and Beyond. AJR Am J Roentgenol 2019. PubMed
  • Bahl M, Maunglay M, D'Alessandro HA, Lehman CD. Comparison of Upright Digital Breast Tomosynthesis-guided versus Prone Stereotactic Vacuum-assisted Breast Biopsy. Radiology 2019; 290:298-304. PubMed
  • Roark AA, Dang PA, Niell BL, Halpern EF, Lehman CD. Performance of Screening Breast MRI After Negative Full-Field Digital Mammography Versus After Negative Digital Breast Tomosynthesis in Women at Higher Than Average Risk for Breast Cancer. AJR Am J Roentgenol 2019; 212:271-279. PubMed
  • Lehman CD, Gatsonis C, Romanoff J, Khan SA, Carlos R, Solin LJ, Badve S, McCaskill-Stevens W, Corsetti RL, Rahbar H, Spell DW, Blankstein KB, Han LK, Sabol JL, Bumberry JR, Gareen I, Snyder BS, Wagner LI, Miller KD, Sparano JA, Comstock C. Association of Magnetic Resonance Imaging and a 12-Gene Expression Assay With Breast Ductal Carcinoma In Situ Treatment. JAMA Oncol 2019. PubMed
  • Lehman CD, Yala A, Schuster T, Dontchos B, Bahl M, Swanson K, Barzilay R. Mammographic Breast Density Assessment Using Deep Learning: Clinical Implementation. Radiology 2018; 290:52-58. PubMed
  • Miles RC, Narayan AK, Lopez DB, Lehman CD, Harvey HB, Mishra V, Glover M, Flores EJ. Chronic Medical Illness as a Risk Factor for Poor Mammography Screening Adherence. J Womens Health (Larchmt) 2018. PubMed
  • Narayan AK, Elkin EB, Lehman CD, Morris EA. Quantifying performance thresholds for recommending screening mammography: a revealed preference analysis of USPSTF guidelines. Breast Cancer Res Treat 2019; 172:463-468. PubMed
  • Punglia RS, Bifolck K, Golshan M, Lehman C, Collins L, Polyak K, Mittendorf E, Garber J, Hwang SE, Schnitt SJ, Partridge AH, King TA. Epidemiology, Biology, Treatment, and Prevention of Ductal Carcinoma In Situ (DCIS). JNCI Cancer Spectr 2019; 2:pky063. PubMed
  • Narayan AK, Flores EJ, Harvey HB, Lehman CD. Population-Based Health Engagement Opportunities Through Breast Imaging: A Population-Based Cross-Sectional Survey. J Am Coll Radiol 2019; 15:1401-1407. PubMed
  • Scheel JR, Kim E, Partridge SC, Lehman CD, Rosen MA, Bernreuter WK, Pisano ED, Marques HS, Morris EA, Weatherall PT, Polin SM, Newstead GM, Esserman LJ, Schnall MD, Hylton NM, . MRI, Clinical Examination, and Mammography for Preoperative Assessment of Residual Disease and Pathologic Complete Response After Neoadjuvant Chemotherapy for Breast Cancer: ACRIN 6657 Trial. AJR Am J Roentgenol 2019; 210:1376-1385. PubMed
  • Scheel JR, Molina Y, Anderson BO, Patrick DL, Nakigudde G, Gralow JR, Lehman CD, Thompson B. Breast Cancer Beliefs as Potential Targets for Breast Cancer Awareness Efforts to Decrease Late-Stage Presentation in Uganda. J Glob Oncol 2019; 4:1-9. PubMed
  • Lee JM, Abraham L, Lam DL, Buist DSM, Kerlikowske K, Miglioretti DL, Houssami N, Lehman CD, Henderson LM, Hubbard RA. Cumulative Risk Distribution for Interval Invasive Second Breast Cancers After Negative Surveillance Mammography. J Clin Oncol 2019; 36:2070-2077. PubMed
  • Scheel JR, Molina Y, Patrick DL, Anderson BO, Nakigudde G, Lehman CD, Thompson B. Breast Cancer Downstaging Practices and Breast Health Messaging Preferences Among a Community Sample of Urban and Rural Ugandan Women. J Glob Oncol 2018; 3:105-113. PubMed
  • Luo J, Johnston BS, Kitsch AE, Hippe DS, Korde LA, Javid S, Lee JM, Peacock S, Lehman CD, Partridge SC, Rahbar H. Ductal Carcinoma in Situ: Quantitative Preoperative Breast MR Imaging Features Associated with Recurrence after Treatment. Radiology 2018; 285:788-797. PubMed
  • Lee JM, Miglioretti DL, Burnside ES, Morris EA, Smith RA, Lehman CD. Mammography Performance Benchmarks in an Era of Value-based Care. Radiology 2019; 284:605-607. PubMed
  • Bolan PJ, Kim E, Herman BA, Newstead GM, Rosen MA, Schnall MD, Pisano ED, Weatherall PT, Morris EA, Lehman CD, Garwood M, Nelson MT, Yee D, Polin SM, Esserman LJ, Gatsonis CA, Metzger GJ, Newitt DC, Partridge SC, Hylton NM, . MR spectroscopy of breast cancer for assessing early treatment response: Results from the ACRIN 6657 MRS trial. J Magn Reson Imaging 2018; 46:290-302. PubMed
  • Scheel JR, Molina Y, Coronado G, Bishop S, Doty S, Jimenez R, Thompson B, Lehman CD, Beresford SA. Healthcare Factors for Obtaining a Mammogram in Latinas With a Variable Mammography History. Oncol Nurs Forum 2018; 44:66-76. PubMed
  • Sprague BL, Arao RF, Miglioretti DL, Henderson LM, Buist DS, Onega T, Rauscher GH, Lee JM, Tosteson AN, Kerlikowske K, Lehman CD, . National Performance Benchmarks for Modern Diagnostic Digital Mammography: Update from the Breast Cancer Surveillance Consortium. Radiology 2018; 283:59-69. PubMed
  • Lehman CD, Arao RF, Sprague BL, Lee JM, Buist DS, Kerlikowske K, Henderson LM, Onega T, Tosteson AN, Rauscher GH, Miglioretti DL. National Performance Benchmarks for Modern Screening Digital Mammography: Update from the Breast Cancer Surveillance Consortium. Radiology 2018; 283:49-58. PubMed
  • Lee JM, Ichikawa L, Valencia E, Miglioretti DL, Wernli K, Buist DSM, Kerlikowske K, Henderson LM, Sprague BL, Onega T, Rauscher GH, Lehman CD. Performance Benchmarks for Screening Breast MR Imaging in Community Practice. Radiology 2018; 285:44-52. PubMed
  • Lee JM, Partridge SC, Liao GJ, Hippe DS, Kim AE, Lee CI, Rahbar H, Scheel JR, Lehman CD. Double reading of automated breast ultrasound with digital mammography or digital breast tomosynthesis for breast cancer screening. Clin Imaging 2019; 55:119-125. PubMed
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