Photo of Daniel Faden, MD

Daniel Faden, MD

Massachusetts General Hospital

Massachusetts General Hospital


dfaden@partners.org

Photo of Daniel Faden, MD

Massachusetts General Hospital


dfaden@partners.org

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Daniel Faden, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Otology and Laryngology, Harvard Medical School
  • Assistant Professor, Otolaryngology- Head and Neck Surgery, Harvard Medical School
  • Assistant Professor, Otolaryngology- Head and Neck Surgery, Massachusetts Eye & Ear Infirmary
  • Assistant Professor, Otolaryngology- Head and Neck Surgery, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

I am a head and neck oncologic surgeon and translational head and neck cancer investigator. My clinical practice focuses on the care of patients with advanced head and neck cancer and cranial base neoplasms, with a particular emphasis on minimally invasive techniques including transoral robotic surgery and endoscopic cranial base surgery. My research focuses on translational head and neck cancer genomics and biomarker discovery for surgical and therapeutic interventions with the aim of improving precision head and neck oncology decision making. To do so, I study how different cellular alterations, and infection by human papilloma virus, effect the behavior of head and neck cancers.

Publications from Harvard Catalyst Profiles

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  • Rettig EM, Faden DL, Sandhu S, Wong K, Faquin WC, Warinner C, Stephens P, Kumar S, Kuperwasser C, Richmon JD, Uppaluri R, Varvares M, Sethi R, Hanna GJ, Sroussi H. Detection of circulating tumor human papillomavirus DNA before diagnosis of HPV-positive head and neck cancer. Int. J. Cancer 2022. PubMed
  • O'Boyle CJ, Siravegna G, Varmeh S, Queenan N, Michel A, Pang KCS, Stein J, Thierauf JC, Sadow PM, Faquin WC, Wang W, Deschler DG, Emerick KS, Varvares MA, Park JC, Clark JR, Chan AW, Busse PM, Corcoran RB, Wirth LJ, Lin DT, Iafrate AJ, Richmon JD, Faden DL. Cell-free human papillomavirus DNA kinetics after surgery for human papillomavirus-associated oropharyngeal cancer. Cancer 2022. PubMed
  • Siravegna G, O'Boyle CJ, Varmeh S, Queenan N, Michel A, Stein J, Thierauf J, Sadow PM, Faquin WC, Perry SK, Bard AZ, Wang W, Deschler DG, Emerick KS, Varvares MA, Park JC, Clark JR, Chan AW, Andreu Arasa VC, Sakai O, Lennerz J, Corcoran RB, Wirth LJ, Lin DT, Iafrate AJ, Richmon JD, Faden DL. Cell-Free HPV DNA Provides an Accurate and Rapid Diagnosis of HPV-Associated Head and Neck Cancer. Clin Cancer Res 2022; 28:719-727. PubMed
  • Vyas A, Harbison RA, Faden DL, Kubik M, Palmer D, Zhang Q, Osmanbeyoglu HU, Kiselyov K, Méndez E, Duvvuri U. Recurrent Human Papillomavirus-Related Head and Neck Cancer Undergoes Metabolic Reprogramming and Is Driven by Oxidative Phosphorylation. Clin Cancer Res 2021; 27:6250-6264. PubMed
  • Wang JJ, Rubin SJ, Devaiah AK, Faden DL, Salama AR, Edwards HA. Long-Term Opioid Use in Post-Surgical Management of Patients With Head and Neck Cancer. Ann. Otol. Rhinol. Laryngol. 2021. PubMed
  • Faden DL, Kuhs KAL, Lin M, Langenbucher A, Pinheiro M, Yeager M, Cullen M, Boland JF, Steinberg M, Bass S, Lewis JS, Lawrence MS, Ferris RL, Mirabello L. APOBEC Mutagenesis Is Concordant between Tumor and Viral Genomes in HPV-Positive Head and Neck Squamous Cell Carcinoma. Viruses 2021. PubMed
  • Faden DL. Liquid biopsy for the diagnosis of HPV-associated head and neck cancer. Cancer Cytopathol 2021. PubMed
  • Feng AL, Holcomb AJ, Abt NB, Mokhtari TE, Suresh K, McHugh CI, Parikh AS, Holman A, Kammer RE, Goldsmith TA, Faden DL, Deschler DG, Varvares MA, Lin DT, Richmon JD. Feeding Tube Placement Following Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma. 2021. PubMed
  • Holcomb AJ, Herberg M, Strohl M, Ochoa E, Feng AL, Abt NB, Mokhtari TE, Suresh K, McHugh CI, Parikh AS, Sadow P, Faquin W, Faden D, Deschler DG, Varvares MA, Lin DT, Fakhry C, Ryan WR, Richmon JD. Impact of surgical margins on local control in patients undergoing single-modality transoral robotic surgery for HPV-related oropharyngeal squamous cell carcinoma. Head Neck 2021. PubMed
  • Lewis JS, Mirabello L, Liu P, Wang X, Dupont WD, Plummer WD, Pinheiro M, Yeager M, Boland JF, Cullen M, Steinberg M, Bass S, Mehrad M, O'Boyle C, Lin M, Faden DL, Lang-Kuhs KA. Oropharyngeal Squamous Cell Carcinoma Morphology and Subtypes by Human Papillomavirus Type and by 16 Lineages and Sublineages. Head Neck Pathol 2021. PubMed
  • Faden DL, O'Boyle CJ, Lin DT, Deschler DG, Emerick KS, Varvares MA, Faquin WC, Sadow PM, Richmon JD. Prospective assessment of multiple HPV-positive oropharyngeal squamous cell carcinomas. Oral Oncol 2021. PubMed
  • Campbell BR, Chen Z, Faden DL, Agrawal N, Li RJ, Hanna GJ, Iyer NG, Boot A, Rozen SG, Vettore AL, Panda B, Krishnan NM, Pickering CR, Myers JN, Guo X, Lang Kuhs KA. The mutational landscape of early- and typical-onset oral tongue squamous cell carcinoma. Cancer 2021; 127:544-553. PubMed
  • Faden DL, Langenbucher A, Kuhs K, Lewis JS, Mirabello L, Yeager M, Boland JF, Bass S, Steinberg M, Cullen M, Lawrence MS, Ferris RL. HPV+ oropharyngeal squamous cell carcinomas from patients with two tumors display synchrony of viral genomes yet discordant mutational profiles and signatures. Carcinogenesis 2021; 42:14-20. PubMed
  • Park JJ, Qureshi MM, Lam CM, Faden DL, Truong MT. A national cancer database analysis on stereotactic body radiation therapy of head and neck cancers. Am J Otolaryngol 2021; 42:102913. PubMed
  • Chang Sing Pang KJW, Mur T, Collins L, Rao SR, Faden DL. Human Papillomavirus in Sinonasal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis. Cancers (Basel) 2020. PubMed
  • Abt NB, Holcomb AJ, Feng AL, Suresh K, Mokhtari TE, McHugh CI, Parikh AS, Faden DL, Deschler DG, Varvares MA, Lin DT, Richmon JD. Opioid Usage and Prescribing Predictors Following Transoral Robotic Surgery for Oropharyngeal Cancer. Laryngoscope 2020. PubMed
  • Hildrew DM, Pang KCS, Faden D. Otolaryngology in the time of COVID: An overview of common open-source telemedicine platforms. Laryngoscope Investig Otolaryngol 2020; 5:839-845. PubMed
  • Bollig CA, Lee DS, Mazul AL, Stepan K, Puram SV, Massa ST, Zenga J, Faden DL, Doering MM, Jackson RS, Pipkorn P. Systematic Review of Second Primary Oropharyngeal Cancers in Patients With p16+ Oropharyngeal Cancer. 2020. PubMed
  • Elgart K, Faden DL. Sinonasal Squamous Cell Carcinoma: Etiology, Pathogenesis, and the Role of Human Papilloma Virus. Curr Otorhinolaryngol Rep 2020; 8:111-119. PubMed
  • Kim KN, Dyer MA, Qureshi MM, Shah NK, Grillone GA, Faden DL, Jalisi SM, Truong MT. Hypofractionated radiotherapy and surgery compared to standard radiotherapy in early glottic cancer. Am J Otolaryngol 2020; 41:102544. PubMed
  • Park JC, Faquin WC, Durbeck J, Faden DL. Immune checkpoint inhibitors in sinonasal squamous cell carcinoma. Oral Oncol 2020. PubMed
  • Strober W, Shishido S, Wood B, Lewis JS, Kuhs K, Ferris RL, Faden DL. Two for the price of one: Prevalence, demographics and treatment implications of multiple HPV mediated Head and Neck Cancers. Oral Oncol 2019; 100:104475. PubMed
  • Faden DL, Ding F, Lin Y, Zhai S, Kuo F, Chan TA, Morris LG, Ferris RL. APOBEC mutagenesis is tightly linked to the immune landscape and immunotherapy biomarkers in head and neck squamous cell carcinoma. Oral Oncol 2019; 96:140-147. PubMed
  • Lavigne P, Faden D, Gardner PA, Fernandez-Miranda JC, Wang EW, Snyderman CH. Validation of training levels in endoscopic endonasal surgery of the skull base. Laryngoscope 2019. PubMed
  • Faden DL, Concha-Benavente F, Chakka AB, McMichael EL, Chandran U, Ferris RL. Immunogenomic correlates of response to cetuximab monotherapy in head and neck squamous cell carcinoma. Head Neck 2019. PubMed
  • Faden DL, Gomez-Casal R, Alvarado D, Duvvuri U. Genomic Correlates of Exceptional Response to ErbB3 Inhibition in Head and Neck Squamous Cell Carcinoma. JCO Precis Oncol 2019. PubMed
  • Lavigne P, Faden DL, Wang EW, Snyderman CH. Complications of Nasoseptal Flap Reconstruction: A Systematic Review. J Neurol Surg B Skull Base 2018; 79:S291-S299. PubMed
  • Faden DL, Hughes MA, Lavigne P, Jankowitz BT, Wang EW, Fernandez-Miranda JC, Gardner PA, Snyderman CH. Diagnosis and endoscopic endonasal management of nontraumatic pseudoaneurysms of the cranial base. Int Forum Allergy Rhinol 2018; 8:641-647. PubMed
  • Markey JD, Alemi AS, Naunheim ML, Faden DL, Heaton CM, Seth R. Spontaneous Iliopsoas Hematoma following Microvascular Free Tissue Transfer. Case Rep Otolaryngol 2017; 2017:7631673. PubMed
  • Faden DL, Asthana S, Tihan T, DeRisi J, Kliot M. Whole Exome Sequencing of Growing and Non-Growing Cutaneous Neurofibromas from a Single Patient with Neurofibromatosis Type 1. PLoS ONE 2017; 12:e0170348. PubMed
  • Faden DL, Thomas S, Cantalupo PG, Agrawal N, Myers J, DeRisi J. Multi-modality analysis supports APOBEC as a major source of mutations in head and neck squamous cell carcinoma. Oral Oncol 2017; 74:8-14. PubMed
  • Faden DL, Arron ST, Heaton CM, DeRisi J, South AP, Wang SJ. Targeted next-generation sequencing of TP53 in oral tongue carcinoma from non-smokers. 2016; 45:47. PubMed
  • Alemi AS, Faden DL. Otolaryngologic Manifestations of Levamisole-Induced Vasculitis. JAMA Otolaryngol Head Neck Surg 2016; 142:299-300. PubMed
  • Li R, Faden DL, Fakhry C, Langelier C, Jiao Y, Wang Y, Wilkerson MD, Pedamallu CS, Old M, Lang J, Loyo M, Ahn SM, Tan M, Gooi Z, Chan J, Richmon J, Wood LD, Hruban RH, Bishop J, Westra WH, Chung CH, Califano J, Gourin CG, Bettegowda C, Meyerson M, Papadopoulos N, Kinzler KW, Vogelstein B, DeRisi JL, Koch WM, Agrawal N. Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke. Head Neck 2015. PubMed
  • Patel KR, Lehmann AE, Jafari A, Faden DL. Prolapsed Nasal Polyp Causing Acute Airway Obstruction: An Exceptional Presentation. ; 83:203-205. PubMed
  • Fadel DL, Gomez R, Alvarado D, Duvvuri U.. Genomic Correlates of Exceptional Response to ErbB3 inhibition in head and neck squamous cell carcinoma. J Clin Oncol .
  • Faden DL, Algazi A. Durable treatment of ameloblastoma with single agent BRAFi J Natl Cancer Inst .
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DF/HCC members that share similar concepts* with Daniel Faden, MD but have yet to coauthor a publication with this researcher.

* Concepts are MeSH terms, automatically derived from member publications

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