Photo of David J. Einstein,  MD

David J. Einstein, MD

Beth Israel Deaconess Medical Center

Beth Israel Deaconess Medical Center

David J. Einstein, MD

Beth Israel Deaconess Medical Center

EDUCATIONAL TITLES

  • Instructor, Medicine, Harvard Medical School
  • Attending Physician, Medicine, Beth Israel Deaconess Medical Center

DF/HCC PROGRAM AFFILIATION

Research Abstract

I am an academic medical oncologist specializing in genitourinary cancers. I care for patients with prostate, bladder, and testicular cancer.

I am interested in clinical trial development and serve as overall PI and site PI of several DFHCC clinical trials that investigate immuno-oncology and targeted agents for GU cancers. I am a member of a team funded by a Challenge Award from the Prostate Cancer Foundation that is exploring immuno-oncology in prostate cancer. I am also interested in biomarkers for differentiating indolent from potentially aggressive "low-risk" prostate cancer, a project supported by a grant from the Department of Defense. I lead the GU Rapid Autopsy project at DFHCC, which offers patients the opportunity to leave a scientific legacy and offers scientists the opportunity to study tumor hetereogeneity and mechanisms of resistance to treatment.

I am also interested in improving physician communication about difficult topics ranging from clinical trial enrollment to advance-care planning. I have published studies of the integration of palliative care into oncologic care and end-of-life discussions between residents and cancer patients, and I have been an invited speaker at the Boston Prostate Cancer Support Group.

Publications

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  • Garnick MB, Einstein DJ. EDITORIAL COMMENT. Urology 2019; 131:182-183. PubMed
  • Einstein DJ, Arai S, Balk SP. Targeting the androgen receptor and overcoming resistance in prostate cancer. Curr Opin Oncol 2019. PubMed
  • Einstein DJ, Patil D, Chipman J, Regan MM, Davis K, Crociani CM, Wagner AA, Sanda M, Chang P. Expanded Prostate Cancer Index Composite-26 (EPIC-26) Online: Validation of an Internet-Based Instrument for Assessment of Health-Related Quality of Life after Treatment for Localized Prostate Cancer. Urology 2019. PubMed
  • Einstein DJ, Sonpavde G. Treatment Approaches for Cisplatin-Ineligible Patients with Invasive Bladder Cancer. Curr Treat Options Oncol 2019; 20:12. PubMed
  • Hennigan ST, Trostel SY, Terrigino NT, Voznesensky OS, Schaefer RJ, Whitlock NC, Wilkinson S, Carrabba NV, Atway R, Shema S, Lake R, Sweet AR, Einstein DJ, Karzai F, Gulley JL, Chang P, Bubley GJ, Balk SP, Ye H, Sowalsky AG. Low Abundance of Circulating Tumor DNA in Localized Prostate Cancer. JCO Precis Oncol 2019. PubMed
  • Einstein DJ. Compassion and Compassionate Use. J Clin Oncol 2018; 36:2969-2971. PubMed
  • Russo JW, Liu X, Ye H, Calagua C, Chen S, Voznesensky O, Condulis J, Ma F, Taplin ME, Einstein DJ, Balk SP, Chen S. Phosphorylation of androgen receptor serine 81 is associated with its reactivation in castration-resistant prostate cancer. Cancer Lett 2018; 438:97-104. PubMed
  • Einstein DJ, McDermott DF. Combined blockade of vascular endothelial growth factor and programmed death 1 pathways in advanced kidney cancer. Clin Adv Hematol Oncol 2017; 15:478-488. PubMed
  • Einstein DJ, DeSanto-Madeya S, Gregas M, Lynch J, McDermott DF, Buss MK. Improving End-of-Life Care: Palliative Care Embedded in an Oncology Clinic Specializing in Targeted and Immune-Based Therapies. J Oncol Pract 2017. PubMed
  • Mathew P, Einstein DJ, Ladin K. Against "Healthy Paternalism" at the End of Life-Reply. JAMA Oncol 2017; 2:833. PubMed
  • Einstein DJ, Ladin K, Mathew P. The Ethical Imperative of Healthy Paternalism in Advance Directive Discussions at the End of Life. JAMA Oncol 2016; 2:429-30. PubMed
  • Einstein DJ, Trowbridge RL, Rencic J. A Problematic Palsy: An Exercise in Clinical Reasoning. J Gen Intern Med 2016; 30:1029-33. PubMed
  • Einstein DJ, Einstein KL, Mathew P. Dying for Advice: Code Status Discussions between Resident Physicians and Patients with Advanced Cancer--A National Survey. J Palliat Med 2015; 18:535-41. PubMed
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