The Marto Lab uses mass spectrometry to interrogate the functional proteome. Our goal is to understand how genomic alterations, environmental insults, or the action of small molecule chemical probes impact individual proteins, their post-translational modifications, biochemical complexes, signaling pathways, or how these perturbations manifest en masse as phenotypic or disease signatures. Our studies are guided by specific hypotheses of biological function or through quantitative, proteome-scale screens which yield data-driven entry points for further investigation.
The interdisciplinary theme of Dr. Marto's research program carries over into the classroom at Harvard Medical School, through the Biological and Biomedical Sciences graduate curriculum. In addition Dr. Marto frequently serves as an ad hoc mentor to junior scientists in our neighboring labs as a result of numerous collaborations through the Blais Proteomics Center at the Dana-Farber.