Research Abstract
Dr. Guerriero's research interests are harnessing the anti-tumor potential of tumor-associated macrophages for cancer immunotherapy in breast cancer. Her group studies the role of tumor associated macrophages both in promoting tumorigenesis as well as how to harness macrophages for cancer therapy. Further mechanistic understanding of how macrophages regulate their phenotype and how they may contribute to resistance to T cell-mediated immunotherapy will have great therapeutic benefit. The major goals of Dr. Guerriero’s work are to elucidate the molecular and functional regulation of tumor macrophage phenotype and subsets, identify how tumor macrophages inhibit T cell function and limit the effectiveness of immunotherapy and identify novel strategies to target macrophages therapeutically.
