Photo of Jennifer Yeh,  PhD

Jennifer Yeh, PhD

Boston Children's Hospital

Boston Children's Hospital
Phone: (857) 218-5577
Fax: (617) 730-0957


jennifer.yeh@childrens.harvard.edu

Jennifer Yeh, PhD

Boston Children's Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Pediatrics, Harvard Medical School
  • Associate Scientific Researcher, Division of General Pediatrics, Boston Children's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

I am a decision scientist whose research focuses on improving cancer outcomes at the population level. I have extensive experience applying decision-analytic modeling and cost-effectiveness analysis methods to evaluate clinical guidelines and health policy. My research spans across the cancer continuum, ranging from gastric cancer prevention to childhood cancer survivorship.

I have developed and applied methods of decision analysis, simulation modeling and economic evaluation to identify opportunities to enhance cancer screening and surveillance programs. In particular, I have developed novel approaches that incorporate the effects of early life exposures on long-term health outcomes. My work on childhood cancers focuses on how treatment-related risks for secondary cancers, cardiac events and other late effects impact long-term survivor health and quality of life. I was recently awarded a grant from the American Cancer Society to evaluate secondary cancer screening guidelines for childhood cancer survivors.

Publications

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  • Atun R, Bhakta N, Denburg A, Frazier AL, Friedrich P, Gupta S, Lam CG, Ward ZJ, Yeh JM, Allemani C, Coleman MP, Di Carlo V, Loucaides E, Fitchett E, Girardi F, Horton SE, Bray F, Steliarova-Foucher E, Sullivan R, Aitken JF, Banavali S, Binagwaho A, Alcasabas P, Antillon F, Arora RS, Barr RD, Bouffet E, Challinor J, Fuentes-Alabi S, Gross T, Hagander L, Hoffman RI, Herrera C, Kutluk T, Marcus KJ, Moreira C, Pritchard-Jones K, Ramirez O, Renner L, Robison LL, Shalkow J, Sung L, Yeoh A, Rodriguez-Galindo C. Sustainable care for children with cancer: a Lancet Oncology Commission. Lancet Oncol. 2020; 21:e185-e224. PubMed
  • Chow EJ, Ness KK, Armstrong GT, Bhakta N, Yeh JM, Bhatia S, Landier W, Constine LS, Hudson MM, Nathan PC. Current and coming challenges in the management of the survivorship population. Semin Oncol 2020. PubMed
  • Yeh JM, Ward ZJ, Chaudhry A, Liu Q, Yasui Y, Armstrong GT, Gibson TM, Howell R, Hudson MM, Krull KR, Leisenring WM, Oeffinger KC, Diller L. Life Expectancy of Adult Survivors of Childhood Cancer Over 3 Decades. JAMA Oncol 2020. PubMed
  • Alagoz O, Hajjar A, Chootipongchaivat S, van Ravesteyn NT, Yeh JM, Ergun MA, de Koning HJ, Chicoine B, Martin B. Benefits and Harms of Mammography Screening for Women With Down Syndrome: a Collaborative Modeling Study. J Gen Intern Med 2019. PubMed
  • Ward ZJ, Yeh JM, Bhakta N, Frazier AL, Girardi F, Atun R. Global childhood cancer survival estimates and priority-setting: a simulation-based analysis. Lancet Oncol. 2019; 20:972-983. PubMed
  • Ward ZJ, Yeh JM, Bhakta N, Frazier AL, Atun R. Estimating the total incidence of global childhood cancer: a simulation-based analysis. Lancet Oncol. 2019; 20:483-493. PubMed
  • Chow EJ, Antal Z, Constine LS, Gardner R, Wallace WH, Weil BR, Yeh JM, Fox E. New Agents, Emerging Late Effects, and the Development of Precision Survivorship. J Clin Oncol 2018. PubMed
  • Yeh JM, Hanmer J, Ward ZJ, Leisenring WM, Armstrong GT, Hudson MM, Stovall M, Robison LL, Oeffinger KC, Diller L. Chronic Conditions and Utility-Based Health-Related Quality of Life in Adult Childhood Cancer Survivors. Journal of the National Cancer Institute 2016. PubMed
  • Yeh JM, Hur C, Ward Z, Schrag D, Goldie SJ. Gastric adenocarcinoma screening and prevention in the era of new biomarker and endoscopic technologies: a cost-effectiveness analysis. Gut 2015. PubMed
  • Yeh JM, Nohria A, Diller L. Routine echocardiography screening for asymptomatic left ventricular dysfunction in childhood cancer survivors: a model-based estimation of the clinical and economic effects. Ann Intern Med 2014; 160:661-71. PubMed
  • Yeh JM, Hur C, Schrag D, Kuntz KM, Ezzati M, Stout N, Ward Z, Goldie SJ. Contribution of H. pylori and smoking trends to US incidence of intestinal-type noncardia gastric adenocarcinoma: a microsimulation model. PLoS Med. 2013; 10:e1001451. PubMed
  • Yeh JM, Diller L. Pediatric Hodgkin lymphoma: trade-offs between short- and long-term mortality risks. Blood 2012; 120:2195-202. PubMed
  • Yeh JM, Hur C, Kuntz KM, Ezzati M, Goldie SJ. Cost-effectiveness of treatment and endoscopic surveillance of precancerous lesions to prevent gastric cancer. Cancer 2010; 116:2941-53. PubMed
  • Yeh JM, Nekhlyudov L, Goldie SJ, Mertens AC, Diller L. A model-based estimate of cumulative excess mortality in survivors of childhood cancer. Ann Intern Med 2010; 152:409-17, W131-8. PubMed
  • Yeh JM, Goldie SJ, Kuntz KM, Ezzati M. Effects of Helicobacter pylori infection and smoking on gastric cancer incidence in China: a population-level analysis of trends and projections. Cancer Causes Control 2009. PubMed
  • Yeh JM,Kuntz KM,Ezzati M,Goldie SJ. Exploring the cost-effectiveness of Helicobacter pylori screening to prevent gastric cancer in China in anticipation of clinical trial results. Int J Cancer 2008; 124:157-66. PubMed
  • Yeh JM,Kuntz KM,Ezzati M,Hur C,Kong CY,Goldie SJ. Development of an empirically calibrated model of gastric cancer in two high-risk countries. Cancer Epidemiol Biomarkers Prev 2008; 17:1179-87. PubMed
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