Photo of Joseph Grossman,  MD

Joseph Grossman, MD

Beth Israel Deaconess Medical Center

Beth Israel Deaconess Medical Center
Phone: (617) 667-2100

Joseph Grossman, MD

Beth Israel Deaconess Medical Center

EDUCATIONAL TITLES

  • Instructor, Medicine, Harvard Medical School
  • Physician, Hematology Oncology, Beth Israel Deaconess Medical Center

DF/HCC PROGRAM AFFILIATION

Research Abstract

I treat patients with gastrointestinal cancers at BIDMC. My research efforts meld with my clinical activities as I seek to expand and improve treatments for my patients through my work with the Muthuswamy Hidalgo lab. I have designed a protocol (HOPE Trial: Harnessing Organoids for Personalized thErapy) that is currently enrolling patients with pancreatic cancer to tailor treatment based on a phenotypic organoid based drug sensitivity assay. Organoids (3D cell culture) also serve as a platform for drug discovery (eventually including immuno-oncology drugs) and as a model to better understand drug resistance. Other research interests include peri-operative immunomodulatory interventions to reduce the risk of cancer recurrence, and clinical research in GI oncology. In addition to my clinical and research roles, I enjoy teaching fellows, residents and medical students in clinic and through HMS courses.

Publications

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  • Kozlova N, Grossman JE, Iwanicki MP, Muranen T. The Interplay of the Extracellular Matrix and Stromal Cells as a Drug Target in Stroma-Rich Cancers. Trends Pharmacol Sci 2020; 41:183-198. PubMed
  • Joseph E Grossman M.D., Yubo Wu M.D., Huihui Ye M.D., Rupal S Bhatt M.D., Ph.D. . Case of Basal Cell Carcinoma of the Prostate Successfully Treated Before and After a BRCA2 Reversion Mutation 2018.