Immune cell modulation is an attractive strategy for the treatment of inflammatory conditions. Inflammation is critical to protecting us from dangers within (e.g. cancer) and without (e.g. microbes). But inflammation also drives much human pathology and disease, including cancers, autoimmune diseases and, potentially, neurodevelopmental disorders.
Towards improved treatments for a range of conditions, we are interested in uncovering novel mechanisms controlling the function and development of pathogenic immune cells. Specifically, we aim to identify host- and bacteria-derived small molecules that control inflammation in mammalian guts. Finally, we are studying the mechanisms by which inflammation dictates neural development.