Photo of Leo L Tsai,  MD, PhD, MSc

Leo L Tsai, MD, PhD, MSc

Beth Israel Deaconess Medical Center

Beth Israel Deaconess Medical Center
Phone: (617) 667-0278
Fax: (617) 667-7917


ltsai1@bidmc.harvard.edu

Leo L Tsai, MD, PhD, MSc

Beth Israel Deaconess Medical Center

EDUCATIONAL TITLES

  • Assistant Professor, Radiology, Harvard Medical School
  • Clinical Director of MRI, Radiology, Beth Israel Deaconess Medical Center

DF/HCC PROGRAM AFFILIATION

Research Abstract

Cancer grading and molecular profiling have become indispensable in the age of personalized therapeutics. Such evaluation requires tissue sampling, which is not always easy to perform, and often impractical for tracking therapeutic response and resistance. Imaging provides a non-invasive way to assess for treatment response, but typically relies on basic metrics such as size or volume, which is often an inaccurate. Our group aims to bridge this diagnostic gap between radiology and pathology through investigation of novel non-invasive MRI-based markers that can highlight loco-regional changes in metabolism, perfusion, and tumor marker expression. Our goal is to provide MRI-based radiogenomic profiles that more accurately reflects tumor treatment sensitivity or therapeutic resistance, translating to increased management precision.

Publications

Powered by Harvard Catalyst
  • Tsai LL, Bhatt RS, Strob MF, Jegede OA, Sun MRM, Alsop DC, Catalano P, McDermott D, Robson PM, Atkins MB, Pedrosa I. Arterial Spin Labeled Perfusion MRI for the Evaluation of Response to Tyrosine Kinase Inhibition Therapy in Metastatic Renal Cell Carcinoma. Radiology 2020. PubMed
  • Xu HS, Balcacer P, Zhang Z, Zhang L, Yee EU, Sun MR, Tsai LL. Characterizing T2 iso- and hypo-intense renal masses on MRI: Can templated algorithms improve accuracy? Clin Imaging 2020; 72:47-54. PubMed
  • Granoff MD, Johnson AR, Shillue K, Fleishman A, Tsai L, Carroll B, Donohoe K, Lee BT, Singhal D. A Single Institution Multi-Disciplinary Approach to Power-Assisted Liposuction for the Management of Lymphedema. Ann Surg 2020. PubMed
  • Moosavi B, Shenoy-Bhangle AS, Tsai LL, Reuf R, Mortele KJ. MRI characterization of focal liver lesions in non-cirrhotic patients: assessment of added value of gadoxetic acid-enhanced hepatobiliary phase imaging. Insights Imaging 2020; 11:101. PubMed
  • Shenoy-Bhangle AS, Putta N, Adondakis M, Rawson J, Tsai LL. Prospective Analysis of Radiology Resource Utilization and Outcomes for Participation in Oncology Multidisciplinary Conferences. Acad Radiol 2020. PubMed
  • Kim G, Smith MP, Donohoe KJ, Johnson AR, Singhal D, Tsai LL. MRI staging of upper extremity secondary lymphedema: correlation with clinical measurements. Eur Radiol 2020. PubMed
  • Johnson AR, Fleishman A, Tran BNN, Shillue K, Carroll B, Tsai LL, Donohoe KJ, James TA, Lee BT, Singhal D. Developing a Lymphatic Surgery Program: A First-Year Review. Plast Reconstr Surg 2019; 144:975e-985e. PubMed
  • Johnson AR, Bravo MG, Granoff MD, Kang CO, Critchlow JF, Tsai LL, Lee BT, Singhal D. Flow-through Omental Flap for Vascularized Lymph Node Transfer: A Novel Surgical Approach for Delayed Lymphatic Reconstruction. Plast Reconstr Surg Glob Open 2019; 7:e2436. PubMed
  • Taso M, Papadopoulou F, Smith MP, Tsai LL, Mortele KJ, Alsop DC. Pancreatic perfusion modulation following glucose stimulation assessed by noninvasive arterial spin labeling (ASL) MRI. J Magn Reson Imaging 2019. PubMed
  • Johnson AR, Tsai LL, Tran BNN, Lin SJ, Singhal D. Reply to the Letter: "Technological advances in Lymphatic Surgery: The Emerging role of Ultrasound". Plast Reconstr Surg 2019. PubMed
  • Beker K, Lee KS, Tsai LL, Hegazi T, Garces-Descovich A, Brook A, Mortele KJ. Differentiation of pancreatic head ductal adenocarcinoma from inflammatory pancreatic pseudomass by MR cholangio-pancreatography: utility of the duct-interrupted, corona, and attraction signs. Abdom Radiol (NY) 2019. PubMed
  • Johnson MT, Smith KC, Tsai LL. Vaginal spindle cell epithelioma: A first complete MRI and histopathologic description. Clin Imaging 2018; 50:181-184. PubMed
  • Tsai LL, Grant AK, Mortele KJ, Kung JW, Smith MP. A Practical Guide to MR Imaging Safety: What Radiologists Need to Know. Radiographics 2015; 35:1722-37. PubMed
  • Berkowitz SJ, Kung JW, Eisenberg RL, Donohoe K, Tsai LL, Slanetz PJ. Resident iPad use: has it really changed the game? J Am Coll Radiol 2014; 11:180-4. PubMed
  • Tsai LL, Donohoe KJ, Stokes MK, Hauser TH, Kolodny GM, Hill TC, Parker JA. Sources of apical defects on a high-sensitivity cardiac camera: experiences from a practice performance assessment. J Nucl Med Technol 2013; 41:197-202. PubMed
  • Tsai LL, Drubach L, Fahey F, Irons M, Voss S, Ullrich NJ. [18F]-Fluorodeoxyglucose positron emission tomography in children with neurofibromatosis type 1 and plexiform neurofibromas: correlation with malignant transformation. J. Neurooncol. 2012; 108:469-75. PubMed
  • Tsai LL, Mair RW, Rosen MS, Patz S, Walsworth RL. An open-access, very-low-field MRI system for posture-dependent 3He human lung imaging. J Magn Reson 2008; 193:274-85. PubMed
  • Tsai LL, Mair RW, Li CH, Rosen MS, Patz S, Walsworth RL. Posture-dependent human 3He lung imaging in an open-access MRI system: initial results. Acad Radiol 2008; 15:728-39. PubMed
  • Klein M, Tsai LL, Rosen MS, Pavlin T, Candela D, Walsworth RL. Interstitial gas and density segregation of vertically vibrated granular media. Phys Rev E Stat Nonlin Soft Matter Phys 2006; 74:010301. PubMed
  • Mair RW, Hrovat MI, Patz S, Rosen MS, Ruset IC, Topulos GP, Tsai LL, Butler JP, Hersman FW, Walsworth RL. 3He lung imaging in an open access, very-low-field human magnetic resonance imaging system. Magn Reson Med 2005; 53:745-9. PubMed
  • Tsai LL, Kaliannan K, Mortele KJ. Gallbladder splenosis: a hereto unreported mimicker of a gallbladder neoplasm. Clin Imaging 2015; 39:318-20. PubMed
  • Tsai LL, Lee KS. Dynamic pancreatography with secretin-MRCP 2015; 44:34-38.
Hide