Photo of Li Lan,  PhD

Li Lan, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-3281


llan1@mgh.harvard.edu

Li Lan, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Radiation Oncology, Harvard Medical School
  • Assistant professor, Radiation Oncology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Oxidative DNA damage is a major source of genomic instability during tumorigenesis and aging. The main research interests of the Lan Laboratory are centered on the mechanisms by which human cells maintain genomic stability against oxidative stress. With a strong appreciation for how human health conditions, especially cancer and neurological maladies, are connected to the loss of genome integrity, ranging from intrinsic genetic predispositions to environmental factors that inflict DNA damage. My lab has developed the first single-cell assay to interrogate the molecular mechanisms of oxidative DNA damage response at specific loci in the genome. By combining this innovative assay with state-of-the-art imaging techniques, we have opened new avenues to understanding the oxidative DNA damage response in different chromosomal environments.

Publications

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  • Zhang JM, Yadav T, Ouyang J, Lan L, Zou L. Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways. Cell Rep 2019; 26:955-968.e3. PubMed
  • Liang Z, Liang F, Teng Y, Chen X, Liu J, Longerich S, Rao T, Green AM, Collins NB, Xiong Y, Lan L, Sung P, Kupfer GM. Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination. Cell Rep 2019; 26:564-572.e5. PubMed
  • Moquin DM, Genois MM, Zhang JM, Ouyang J, Yadav T, Buisson R, Yazinski SA, Tan J, Boukhali M, Gagné JP, Poirier GG, Lan L, Haas W, Zou L. Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination. Genes Dev 2019; 33:75-89. PubMed
  • Teng Y, Yadav T, Duan M, Tan J, Xiang Y, Gao B, Xu J, Liang Z, Liu Y, Nakajima S, Shi Y, Levine AS, Zou L, Lan L. ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB. Nat Commun 2018; 9:4115. PubMed
  • Yaqun Teng, Tribhuwan Yadav, Meihan Duan, Jun Tan, Yufei Xiang, Boya Gao, Jianquan Xu, Zhuobin Liang, Yang Liu, Satoshi Nakajima, Yi Shi, Arthur S. Levine, Lee Zou & Li Lan. ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB 2018.