Photo of Liron Bar-Peled,  PhD

Liron Bar-Peled, PhD

Massachusetts General Hospital

Massachusetts General Hospital


lbar-peled@mgh.harvard.edu

Liron Bar-Peled, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Medicine, Harvard Medical School
  • Investigator, Center for Cancer Research, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Cancer cells display remarkable plasticity allowing them to adapt to ever changing environments. A key feature of this plasticity is their ability to rewire core metabolic networks to provide a steady source of energy and building blocks needed for rapid growth. This demand for energy produces byproducts including reactive oxygen species (ROS) that alter the function of proteins, DNA and lipids, and if left unchecked, results in oxidative stress and impairs cancer cell viability. We now appreciate that ROS and other reactive metabolites are not just static entities within a cell, but represent dynamic signaling molecules that alter cellular and organismal physiology. Despite decades of research, we know surprisingly little about about ROS sensing and signaling and how this class of molecules regulates protein function within the cell. Our long term goals are to understand how cells respond to altered metabolic states and to pharmacologically modulate these pathways in diseases where they are deregulated.

Publications

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  • Rasheed N, Lima TB, Mercaldi GF, Nascimento AFZ, Silva ALS, Righetto GL, Bar-Peled L, Shen K, Sabatini DM, Gozzo FC, Aparicio R, Smetana JHC. C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly. FEBS Open Bio 2019; 9:1589-1602. PubMed
  • Chen AL, Lum KM, Lara-Gonzalez P, Ogasawara D, Cognetta AB, To A, Parsons WH, Simon GM, Desai A, Petrascheck M, Bar-Peled L, Cravatt BF. Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan. Nat Chem Biol 2019; 15:453-462. PubMed
  • Lamming DW, Bar-Peled L. Lysosome: The metabolic signaling hub. Traffic 2018; 20:27-38. PubMed
  • Bar-Peled L, Kemper EK, Suciu RM, Vinogradova EV, Backus KM, Horning BD, Paul TA, Ichu TA, Svensson RU, Olucha J, Chang MW, Kok BP, Zhu Z, Ihle NT, Dix MM, Jiang P, Hayward MM, Saez E, Shaw RJ, Cravatt BF. Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer. Cell 2018; 171:696-709.e23. PubMed
  • Tsun ZY, Bar-Peled L, Chantranupong L, Zoncu R, Wang T, Kim C, Spooner E, Sabatini DM. The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell 2018; 52:495-505. PubMed
  • Bar-Peled L, Chantranupong L, Cherniack AD, Chen WW, Ottina KA, Grabiner BC, Spear ED, Carter SL, Meyerson M, Sabatini DM. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science 2013; 340:1100-6. PubMed