My work seeks to understand the role of the tumor microenvironment in the formation and progression of brain tumors, with emphasis on the tumor extracellular matrix (ECM). We specifically investigate how tumor cells introduce changes in the brain ECM and how these changes trigger mechanisms that facilitate brain tumor dispersion and resistance to conventional therapies. Understanding these mechanisms has allowed us to develop targeted biological agents that may disrupt tumor growth and invasion, which are currently under pre-clinical investigation. Since my first independent appointment in 2006, my laboratory has trained and continues to train undergraduates, graduate and medical students, and postdoctoral researchers in the field of brain cancer biology, thanks to support from NIH, NSF, the American Brain Tumor Association, the National Brain Tumor Society, and the International Brain Research Organization, among others. I have directed multiple neuroscience courses and developed graduate-level courses specifically focused on tumor microenvironment. I continue to be actively engaged in teaching and mentoring activities together with my research in brain tumor biology.