Photo of Martha B. Pitman,  MD

Martha B. Pitman, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-3185
Fax: (617) 724-6564


mpitman@partners.org

Martha B. Pitman, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Pathology, Harvard Medical School
  • Director of Cytopathology, Pathologist, Pathology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My clinical practice focuses on the early diagnosis of cancer using the cytological method of diagnosis. My clinical research has centered on pre-operative diagnosis of pancreatic cancer, especially early cancer arising in pancreatic cysts. I have demonstrated the value of cyst fluid analysis using a multimodal approach which incorporates cytological analysis of the cells in the cyst fluid, biochemical and molecular testing with clinical and imaging characteristics of the pancreatic cyst, for accurate diagnosis. This research was the first to correlate cytological and histological features of IPMN, to demonstrate the superior accuracy of cytology over imaging in the early detection of malignant cysts, and to demonstrate the value of integrating all ancillary testing of cyst fluid into a comprehensive pathological diagnosis. I have defined the cytological features of high-grade cellular atypia in pancreatic mucinous cysts and led a multidisciplinary team that developed an international standardized terminology system for cytological diagnosis of pancreaticobiliary cytology. I have over 25 years experience as a diagnostic cytopathologist and am a recognized international expert in the field, especially with regard to the interpretation of pancreatic cytology.

Publications

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  • Saieg M, Pitman MB. Experience and future perspectives on the use of the Papanicolaou Society of Cytopathology Terminology System for reporting pancreaticobiliary cytology. Diagn Cytopathol 2020; 48:494-498. PubMed
  • Chen AL, Janko E, Pitman MB, Chebib I. Clinical, cytologic, and immunohistochemical features of sarcomas involving body cavity fluids. Cancer Cytopathol 2019; 127:778-784. PubMed
  • Das KK, Geng X, Brown JW, Morales-Oyarvide V, Huynh T, Pergolini I, Pitman MB, Ferrone C, Al Efishat M, Haviland D, Thompson E, Wolfgang C, Lennon AM, Allen P, Lillemoe KD, Fields RC, Hawkins WG, Liu J, Castillo CF, Das KM, Mino-Kenudson M. Cross Validation of the Monoclonal Antibody Das-1 in Identification of High-risk Mucinous Pancreatic Cystic Lesions. Gastroenterology 2019. PubMed
  • Kuvendjiska J, Bronsert P, Martini V, Lang S, Pitman MB, Hoeppner J, Kulemann B. Non-Metastatic Esophageal Adenocarcinoma: Circulating Tumor Cells in the Course of Multimodal Tumor Treatment. Cancers (Basel) 2019. PubMed
  • Fitzpatrick MJ, Hernandez-Barco YG, Krishnan K, Brugge W, Casey B, Pitman MB. Diagnostic yield of the SharkCore EUS-guided fine-needle biopsy. J Am Soc Cytopathol 2019. PubMed
  • Finer EB, Villalba JA, Pitman MB. Granular cell tumor of the lung. Diagn Cytopathol 2018. PubMed
  • Hoda RS, Lu R, Arpin RN, Rosenbaum MW, Pitman MB. Risk of malignancy in pancreatic cysts with cytology of high-grade epithelial atypia. Cancer Cytopathol 2018. PubMed
  • Hoda RS, Pitman MB. Pancreatic Cytology. 2018; 11:563-588. PubMed
  • Misdraji J, Centeno BA, Pitman MB. Ancillary tests in the diagnosis of liver and pancreatic neoplasms. Cancer Cytopathol 2018; 126 Suppl 8:672-690. PubMed
  • Zhang ML, Arpin RN, Brugge WR, Forcione DG, Basar O, Pitman MB. Moray micro forceps biopsy improves the diagnosis of specific pancreatic cysts. Cancer Cytopathol 2018; 126:414-420. PubMed
  • Basar O, Yuksel O, Yang D, Samarasena J, Forcione D, DiMaio CJ, Wagh MS, Chang K, Casey B, Fernandez-Del Castillo C, Pitman MB, Brugge WR. Feasibility and safety of micro-forceps biopsy in the diagnosis of pancreatic cysts. Gastrointest Endosc 2018. PubMed
  • Chebib I, Albanese E, Scourtas A, Pitman MB. Inspissated cyst fluid in endoscopic ultrasound-guided fine needle aspiration of pancreatic cysts. Diagn Cytopathol 2018. PubMed
  • Kulemann B, Rösch S, Seifert S, Timme S, Bronsert P, Seifert G, Martini V, Kuvendjiska J, Glatz T, Hussung S, Fritsch R, Becker H, Pitman MB, Hoeppner J. Pancreatic cancer: Circulating Tumor Cells and Primary Tumors show Heterogeneous KRAS Mutations. Sci Rep 2017; 7:4510. PubMed
  • Pitman MB, Black-Schaffer WS. Post-fine-needle aspiration biopsy communication and the integrated and standardized cytopathology report. Cancer 2017; 125:486-493. PubMed
  • Chen AL, Misdraji J, Brugge WR, Ferrone CR, Pitman MB. Acinar cell cystadenoma: A challenging cytology diagnosis, facilitated by moray(®) micro-forceps biopsy. Diagn Cytopathol 2017. PubMed
  • Rosenbaum MW, Jones M, Dudley JC, Le LP, Iafrate AJ, Pitman MB. Next-generation sequencing adds value to the preoperative diagnosis of pancreatic cysts. Cancer 2016; 125:41-47. PubMed
  • Scourtas A, Dudley JC, Brugge WR, Kadayifci A, Mino-Kenudson M, Pitman MB. Preoperative characteristics and cytological features of 136 histologically confirmed pancreatic mucinous cystic neoplasms. Cancer 2016. PubMed
  • Ly A, Ono JC, Hughes KS, Pitman MB, Balassanian R. Fine-Needle Aspiration Biopsy of Palpable Breast Masses: Patterns of Clinical Use and Patient Experience. J Natl Compr Canc Netw 2016; 14:527-36. PubMed
  • Dudley JC, Zheng Z, McDonald T, Le LP, Dias-Santagata D, Borger D, Batten J, Vernovsky K, Sweeney B, Arpin RN, Brugge WR, Forcione DG, Pitman MB, Iafrate AJ. Next-Generation Sequencing and Fluorescence in Situ Hybridization Have Comparable Performance Characteristics in the Analysis of Pancreaticobiliary Brushings for Malignancy. J Mol Diagn 2015. PubMed
  • Jones M, Zheng Z, Wang J, Dudley J, Albanese E, Kadayifci A, Dias-Santagata D, Le L, Brugge WR, Castillo CF, Mino-Kenudson M, Iafrate AJ, Pitman MB. Impact of next-generation sequencing on the clinical diagnosis of pancreatic cysts. Gastrointest Endosc 2015. PubMed
  • Pitman MB, Centeno BA, Ali SZ, Genevay M, Stelow E, Mino-Kenudson M, Fernandez-del Castillo C, Max Schmidt C, Brugge W, Layfield L, . Standardized terminology and nomenclature for pancreatobiliary cytology: the Papanicolaou Society of Cytopathology guidelines. Diagn Cytopathol 2014; 42:338-50. PubMed
  • Pitman MB, Centeno BA, Ali SZ, Genevay M, Stelow E, Mino-Kenudson M, Castillo CF, Schmidt CM, Brugge WR, Layfield LJ. Standardized terminology and nomenclature for pancreatobiliary cytology: The Papanicolaou Society of Cytopathology Guidelines. Cytojournal 2014; 11:3. PubMed
  • Hoda RS, Finer EB, Arpin RN, Rosenbaum M, Pitman MB. Risk of malignancy in the categories of the Papanicolaou Society of Cytopathology system for reporting pancreaticobiliary cytology. J Am Soc Cytopathol 2019; 8:120-127. PubMed
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