Martin E. Dorf, PhD

Harvard Medical School

Harvard Medical School
Phone: (617) 432-1978
Fax: (617) 432-2789

dorf@hms.harvard.edu

Harvard Medical School
Phone: (617) 432-1978
Fax: (617) 432-2789

dorf@hms.harvard.edu

RAKESH K. JAIN, PHD
Massachusetts General Hospital

ANGIOGENESIS, INVASION AND METASTASIS, BREAST CANCER, NEURO-ONCOLOGY
ANTHONY G. LETAI, MD, PHD
Dana-Farber Cancer Institute

CANCER CELL BIOLOGY, LEUKEMIA, LYMPHOMA AND MYELOMA

Martin E. Dorf, PhD

Harvard Medical School

EDUCATIONAL TITLES

Professor, Microbiology and Immunobiology, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Cancer Cell Biology, Member
Cancer Immunology, Member

Research Abstract

Our lab works in the broad fields of cell signaling, ubiquitination and gene regulation with special emphasis on applying these systems to investigate cell growth and innate immunity. Research in my lab uses a combination of cellular and molecular methodologies for analysis of host responses. Our lab has made extensive use of genetic and proteomic-based tools to identify novel cellular interaction partners for the NF-kB and IRF signaling systems. In many cases we identified critical roles for E3 ubiquitin ligases in these pathways.

Zhao M, Song K, Hao W, Wang L, Patil G, Li Q, Xu L, Hua F, Fu B, Schwamborn JC, Dorf ME, Li S. Non-proteolytic ubiquitination of OTULIN regulates NF-κB signaling pathway. 2019. PubMed
Swamydas M, Luo Y, Dorf ME, Lionakis MS. Isolation of Mouse Neutrophils. Curr Protoc Immunol 2015; 110:3.20.1-3.20.15. PubMed
Li S, Wang L, Fu B, Berman MA, Diallo A, Dorf ME. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. Proc Natl Acad Sci U S A 2014. PubMed
Fu B, Li S, Wang L, Berman MA, Dorf ME. The ubiquitin conjugating enzyme UBE2L3 regulates TNFÎ±-induced linear ubiquitination. Cell Res 2014; 24:510. PubMed
Fu B, Li S, Wang L, Berman MA, Dorf ME. The ubiquitin conjugating enzyme UBE2L3 regulates TNFα-induced linear ubiquitination. Cell Res 2014; 24:376-9. PubMed
Wang L, Li S, Dorf ME. NEMO binds ubiquitinated TANK-binding kinase 1 (TBK1) to regulate innate immune responses to RNA viruses. PLoS ONE 2012; 7:e43756. PubMed
Li S, Wang L, Berman M, Kong YY, Dorf ME. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity 2011; 35:426-40. PubMed
Abromson-Leeman S, Bronson RT, Dorf ME. Encephalitogenic T cells that stably express both T-bet and ROR gamma t consistently produce IFNgamma but have a spectrum of IL-17 profiles. J Neuroimmunol 2009; 215:10-24. PubMed
Li S,Wang L,Dorf ME. PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination. Mol Cell 2009; 33:30-42. PubMed
Di Y, Li S, Wang L, Zhang Y, Dorf ME. Homeostatic interactions between MEKK3 and TAK1 involved in NF-kappaB signaling. Cell Signal 2008; 20:705-13. PubMed
Sidorov A, Dorf M, Zorin V, Bokhanov A, Izotov I, Razin S, Skalyga V, Rossbach J, Spadtke P, Balabaev A. Multiaperture ion beam extraction from gas-dynamic electron cyclotron resonance source of multicharged ions. Rev Sci Instrum 2008; 79:02A317. PubMed

Abromson-Leeman S, Ladell DS, Bronson RT, Dorf ME. Heterogeneity of EAE mediated by multiple distinct T-effector subsets. J Neuroimmunol 2007; 192:3-12. PubMed
Li S, Wang L, Berman MA, Zhang Y, Dorf ME. RNAi screen in mouse astrocytes identifies phosphatases that regulate NF-kappaB signaling. Mol Cell 2006; 24:497-509. PubMed

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Martin E. Dorf, PhD

Harvard Medical School

Similar Members

Similar Members

Martin E. Dorf, PhD

Harvard Medical School

EDUCATIONAL TITLES

DF/HCC PROGRAM AFFILIATION

Research Abstract

Publications from Harvard Catalyst Profiles

Similar Members

Similar Members