Research Abstract
My laboratory has created models of diseases, including models of progressive neurological degenerations and cancer, in Drosophila. We are now exploiting genetic analysis in Drosophila with confirmatory studies in a variety of model organisms and in patients to investigate the role of various cellular pathways, including control of cell cycle, in these disorders. My clinical research has also focused on the control of cell cycle with studies of the proliferative potential of human astrocytes in the adult and pediatric brain.