Photo of Michael R. Hamblin,  PhD

Michael R. Hamblin, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-6182
Fax: (617) 726-8566

Michael R. Hamblin, PhD

Massachusetts General Hospital


  • Associate Professor, Dermatology, Harvard Medical School
  • Associate Chemist, Dermatology, Massachusetts General Hospital


Research Abstract

Photodynamic therapy is a relatively new and exciting approach for treating cancers and other diseases. Many new photosensitizers have been developed in recent years, but it is still not clear what is the basic mechanism of the tumor localizing effect, and hence the optimum structure and formulation of the photosensitizer for any particular application is uncertain.

My particular area of interest is in the preparation and investigation of macromolecular conjugates of photosensitizers. Large molecules have very different biodistribution and pharmacokinetics compared to the small molecules which are generally used as photosensitizers. In addition it may be possible to use conjugates of photosensitizers with specifically targeted macromolecules to cancer cells and other defined cells and organs. I am also interested in the use of PDT to generate long-term specific anti-tumor immunity in immunocompetent mouse tumor models, and its relation to specific PDT parameters.

Examples of the above approaches are,

(a) the use of monoclonal antibody photosensitizer conjugates directed towards tumor associated antigens to target metastatic ovarian and colorectal cancer.

(b) the use of conjugates with polyamino acids which can vary in size, charge and hydrophobicity and can therefore produce different pharmacokinetics, biodistributions and enhanced phototoxicities.

(c) targeting pathogenic bacteria which may produce wound infections or other diseases with polycationic photosensitizer conjugates

(d) the use of conjugates with serum proteins such as albumin and lipoproteins which could have improved tumor targeting properties and specificity for macrophage type cells.

(e) the use of macromolecular conjugates to direct photosensitizers to subcellular locations such as lysosomes, mitochondria and membranes, where they could either increase the cytotoxic effect, or conversely not kill the cell but induce it to express cytokines or growth factors which could be advantageous in such areas as wound healing.


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  • Ghaffari M, Dehghan G, Baradaran B, Zarebkohan A, Mansoori B, Soleymani J, Ezzati Nazhad Dolatabadi J, Hamblin MR. Co-delivery of curcumin and Bcl-2 siRNA by PAMAM dendrimers for enhancement of the therapeutic efficacy in HeLa cancer cells. 2020; 188:110762. PubMed
  • Oroojalian F, Charbgoo F, Hashemi M, Amani A, Yazdian-Robati R, Mokhtarzadeh A, Ramezani M, Hamblin MR. Recent advances in nanotechnology-based drug delivery systems for the kidney. J Control Release 2020; 321:442-462. PubMed
  • Amiri A, Pourhanifeh MH, Mirzaei HR, Nahand JS, Moghoofei M, Sahebnasagh R, Mirzaei H, Hamblin MR. Exosomes and Lung cancer: Roles in pathophysiology, diagnosis and therapeutic applications. Curr Med Chem 2020. PubMed
  • Mansoori B, Mohammadi A, Abedi-Gaballu F, Abbaspour S, Ghasabi M, Yekta R, Shirjang S, Dehghan G, Hamblin MR, Baradaran B. Hyaluronic acid-decorated liposomal nanoparticles for targeted delivery of 5-fluorouracil into HT-29 colorectal cancer cells. J Cell Physiol 2020. PubMed
  • Kheiriabad S, Ghaffari M, Dolatabadi JEN, Hamblin MR. PAMAM Dendrimers as a Delivery System for Small Interfering RNA. Methods Mol Biol 2020; 2115:91-106. PubMed
  • Naeli P, Pourhanifeh MH, Karimzadeh MR, Shabaninejad Z, Movahedpour A, Tarrahimofrad H, Mirzaei HR, Bafrani HH, Savardashtaki A, Mirzaei H, Hamblin MR. Circular RNAs and gastrointestinal cancers: Epigenetic regulators with a prognostic and therapeutic role. Crit Rev Oncol Hematol 2019; 145:102854. PubMed
  • Jahanafrooz Z, Baradaran B, Mosafer J, Hashemzaei M, Rezaei T, Mokhtarzadeh A, Hamblin MR. Comparison of DNA and mRNA vaccines against cancer. Drug Discov Today 2019. PubMed
  • Hamblin MR. Photodynamic Therapy for Cancer: What's Past is Prologue. Photochem Photobiol 2019. PubMed
  • Doustvandi MA, Mohammadnejad F, Mansoori B, Tajalli H, Mohammadi A, Mokhtarzadeh A, Baghbani E, Khaze V, Hajiasgharzadeh K, Moghaddam MM, Hamblin MR, Baradaran B. Photodynamic therapy using zinc phthalocyanine with low dose of diode laser combined with doxorubicin is a synergistic combination therapy for human SK-MEL-3 melanoma cells. Photodiagnosis Photodyn Ther 2019; 28:88-97. PubMed
  • Savardashtaki A, Shabaninejad Z, Movahedpour A, Sahebnasagh R, Mirzaei H, Hamblin MR. miRNAs derived from cancer-associated fibroblasts in colorectal cancer. Epigenomics 2019; 11:1627-1645. PubMed
  • Sadri Nahand J, Moghoofei M, Salmaninejad A, Bahmanpour Z, Karimzadeh M, Nasiri M, Mirzaei HR, Pourhanifeh MH, Bokharaei-Salim F, Mirzaei H, Hamblin MR. Pathogenic role of exosomes and microRNAs in HPV-mediated inflammation and cervical cancer: A review. Int. J. Cancer 2019. PubMed
  • Negri LB, Martins TJ, da Silva RS, Hamblin MR. Photobiomodulation combined with photodynamic therapy using ruthenium phthalocyanine complexes in A375 melanoma cells: Effects of nitric oxide generation and ATP production. J. Photochem. Photobiol. B, Biol. 2019; 198:111564. PubMed
  • Feng X, Muzikansky A, Ross AH, Hamblin MR, Jermain PR, Yaroslavsky AN. Multimodal quantitative imaging of brain cancer in cultured cells. Biomed Opt Express 2019; 10:4237-4248. PubMed
  • Hajebi S, Rabiee N, Bagherzadeh M, Ahmadi S, Rabiee M, Roghani-Mamaqani H, Tahriri M, Tayebi L, Hamblin MR. Stimulus-responsive polymeric nanogels as smart drug delivery systems. Acta Biomater 2019; 92:1-18. PubMed
  • Jafari Najaf Abadi MH, Shafabakhsh R, Asemi Z, Mirzaei HR, Sahebnasagh R, Mirzaei H, Hamblin MR. CFIm25 and alternative polyadenylation: Conflicting roles in cancer. Cancer Lett 2019; 459:112-121. PubMed
  • Mansoori B, Mohammadi A, Amin Doustvandi M, Mohammadnejad F, Kamari F, Gjerstorff MF, Baradaran B, Hamblin MR. Photodynamic therapy for cancer: Role of natural products. Photodiagnosis Photodyn Ther 2019; 26:395-404. PubMed
  • Sedighi M, Zahedi Bialvaei A, Hamblin MR, Ohadi E, Asadi A, Halajzadeh M, Lohrasbi V, Mohammadzadeh N, Amiriani T, Krutova M, Amini A, Kouhsari E. Therapeutic bacteria to combat cancer; current advances, challenges, and opportunities. Cancer Med 2019. PubMed
  • Wen X, Li Y, Hamblin MR. A Microneedling Fractional Radiofrequency Device for the Treatment of Nevus Comedonicus. Dermatol Surg 2019. PubMed
  • Yaroslavsky AN, Feng X, Muzikansky A, Hamblin MR. Fluorescence Polarization of Methylene Blue as a Quantitative Marker of Breast Cancer at the Cellular Level. Sci Rep 2019; 9:940. PubMed
  • Abedi-Gaballu F, Dehghan G, Ghaffari M, Yekta R, Abbaspour-Ravasjani S, Baradaran B, Dolatabadi JEN, Hamblin MR. PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy. Appl Mater Today 2018; 12:177-190. PubMed
  • Ramos LCB, Rodrigues FP, Biazzotto JC, de Paula Machado S, Slep LD, Hamblin MR, da Silva RS. Targeting the mitochondrial VDAC in hepatocellular carcinoma using a polyclonal antibody-conjugated to a nitrosyl ruthenium complex. J. Biol. Inorg. Chem. 2018. PubMed
  • Odinokov D, Hamblin MR. Aging of lymphoid organs: Can photobiomodulation reverse age-associated thymic involution via stimulation of extrapineal melatonin synthesis and bone marrow stem cells? J Biophotonics 2017. PubMed
  • Wen X, Li Y, Hamblin MR. Photodynamic therapy in dermatology beyond non-melanoma cancer: an update. Photodiagnosis Photodyn Ther 2017. PubMed
  • Barolet D, Christiaens F, Hamblin MR. Infrared and skin: Friend or foe. J. Photochem. Photobiol. B, Biol. 2016; 155:78-85. PubMed
  • Yu C, Avci P, Canteenwala T, Chiang LY, Chen BJ, Hamblin MR. Photodynamic Therapy with Hexa(sulfo-n-butyl)[60]Fullerene Against Sarcoma In Vitro and In Vivo. J Nanosci Nanotechnol 2016; 16:171-81. PubMed
  • Broekgaarden M, Weijer R, van Gulik TM, Hamblin MR, Heger M. Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies. Cancer Metastasis Rev 2015; 34:643-90. PubMed
  • Anzengruber F, Avci P, de Freitas LF, Hamblin MR. T-cell mediated anti-tumor immunity after photodynamic therapy: why does it not always work and how can we improve it? Photochem Photobiol Sci 2015. PubMed
  • Santos Z, Avci P, Hamblin MR. Drug discovery for alopecia: gone today, hair tomorrow. Expert Opin Drug Discov 2015; 10:269-92. PubMed
  • Garg AD, Galluzzi L, Apetoh L, Baert T, Birge RB, Bravo-San Pedro JM, Breckpot K, Brough D, Chaurio R, Cirone M, Coosemans A, Coulie PG, De Ruysscher D, Dini L, de Witte P, Dudek-Peric AM, Faggioni A, Fucikova J, Gaipl US, Golab J, Gougeon ML, Hamblin MR, Hemminki A, Herrmann M, Hodge JW, Kepp O, Kroemer G, Krysko DV, Land WG, Madeo F, Manfredi AA, Mattarollo SR, Maueroder C, Merendino N, Multhoff G, Pabst T, Ricci JE, Riganti C, Romano E, Rufo N, Smyth MJ, Sonnemann J, Spisek R, Stagg J, Vacchelli E, Vandenabeele P, Vandenberk L, Van den Eynde BJ, Van Gool S, Velotti F, Zitvogel L, Agostinis P. Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death. 2015; 6:588. PubMed
  • Xia Y, Gupta GK, Castano AP, Mroz P, Avci P, Hamblin MR. CpG oligodeoxynucleotide as immune adjuvant enhances photodynamic therapy response in murine metastatic breast cancer. J Biophotonics 2014. PubMed
  • Arany PR, Cho A, Hunt TD, Sidhu G, Shin K, Hahm E, Huang GX, Weaver J, Chen AC, Padwa BL, Hamblin MR, Barcellos-Hoff MH, Kulkarni AB, J Mooney D. Photoactivation of endogenous latent transforming growth factor-β1 directs dental stem cell differentiation for regeneration. Sci Transl Med 2014; 6:238ra69. PubMed
  • Wachowska M, Gabrysiak M, Muchowicz A, Bednarek W, Barankiewicz J, Rygiel T, Boon L, Mroz P, Hamblin MR, Golab J. 5-Aza-2'-deoxycytidine potentiates antitumour immune response induced by photodynamic therapy. Eur J Cancer 2014; 50:1370-81. PubMed
  • Vecchio D, Bhayana B, Huang L, Carrasco E, Evans CL, Hamblin MR. Structure-function relationships of Nile blue (EtNBS) derivatives as antimicrobial photosensitizers. Eur J Med Chem 2014; 75:479-91. PubMed
  • Gupta A, Dai T, Hamblin MR. Effect of red and near-infrared wavelengths on low-level laser (light) therapy-induced healing of partial-thickness dermal abrasion in mice. Lasers Med Sci 2014. PubMed
  • Dai T, Gupta A, Huang YY, Sherwood ME, Murray CK, Vrahas MS, Kielian T, Hamblin MR. Blue light eliminates community-acquired methicillin-resistant Staphylococcus aureus in infected mouse skin abrasions. 2013. PubMed
  • Mroz P, Vatansever F, Muchowicz A, Hamblin MR. Photodynamic therapy of murine mastocytoma induces specific immune responses against the cancer/testis antigen P1A. Cancer Res 2013; 73:6462-70. PubMed
  • Huang YY, Nagata K, Tedford CE, McCarthy T, Hamblin MR. Low-level laser therapy (LLLT) reduces oxidative stress in primary cortical neurons in vitro. J Biophotonics 2013. PubMed
  • Sperandio FF, Giudice FS, Corrêa L, Pinto DS, Hamblin MR, de Sousa SC. Low-level laser therapy can produce increased aggressiveness of dysplastic and oral cancer cell lines by modulation of Akt/mTOR signaling pathway. J Biophotonics 2013. PubMed
  • Aquino AE, Sene-Fiorese M, Paolillo FR, Duarte FO, Oishi JC, Pena AA, Duarte AC, Hamblin MR, Bagnato VS, Parizotto NA. Low-level laser therapy (LLLT) combined with swimming training improved the lipid profile in rats fed with high-fat diet. Lasers Med Sci 2013. PubMed
  • Vecchio D, Dai T, Huang L, Fantetti L, Roncucci G, Hamblin MR. Antimicrobial photodynamic therapy with RLP068 kills methicillin-resistant Staphylococcus aureus and improves wound healing in a mouse model of infected skin abrasion PDT with RLP068/Cl in infected mouse skin abrasion. J Biophotonics 2013. PubMed
  • Sperandio FF, Huang YY, Hamblin MR. Antimicrobial photodynamic therapy to kill Gram-negative bacteria. Recent Pat Antiinfect Drug Discov 2013. PubMed
  • G N, Tan A, Farhatnia Y, Rajadas J, Hamblin MR, Khaw PT, Seifalian AM. Channelrhodopsins: visual regeneration and neural activation by a light switch. 2013. PubMed
  • St Denis TG, Hamblin MR. Synthesis, bioanalysis and biodistribution of photosensitizer conjugates for photodynamic therapy. Bioanalysis 2013; 5:1099-114. PubMed
  • Tanaka M, Mroz P, Dai T, Huang L, Morimoto Y, Kinoshita M, Yoshihara Y, Shinomiya N, Seki S, Nemoto K, Hamblin MR. Linezolid and vancomycin decrease the therapeutic effect of methylene blue-photodynamic therapy in a mouse model of MRSA bacterial arthritis. Photochem Photobiol 2013; 89:679-82. PubMed
  • Sperandio FF, Sharma SK, Wang M, Jeon S, Huang YY, Dai T, Nayka S, de Sousa SC, Chiang LY, Hamblin MR. Photoinduced electron-transfer mechanisms for radical-enhanced photodynamic therapy mediated by water-soluble decacationic C₇₀ and C₈₄O₂ Fullerene Derivatives. 2013. PubMed
  • Wang M, Maragani S, Huang L, Jeon S, Canteenwala T, Hamblin MR, Chiang LY. Synthesis of decacationic [60]fullerene decaiodides giving photoinduced production of superoxide radicals and effective PDT-mediation on antimicrobial photoinactivation. Eur J Med Chem 2013; 63C:170-84. PubMed
  • Kokel D, Cheung CY, Mills R, Coutinho-Budd J, Huang L, Setola V, Sprague J, Jin S, Jin YN, Huang XP, Bruni G, Woolf CJ, Roth BL, Hamblin MR, Zylka MJ, Milan DJ, Peterson RT. Photochemical activation of TRPA1 channels in neurons and animals. Nat Chem Biol 2013; 9:257-63. PubMed
  • Dai T, Gupta A, Huang YY, Yin R, Murray CK, Vrahas MS, Sherwood ME, Tegos GP, Hamblin MR. Blue light rescues mice from potentially fatal Pseudomonas aeruginosa burn infection: efficacy, safety, and mechanism of action. Antimicrob Agents Chemother 2013; 57:1238-45. PubMed
  • Avci P, Sadasivam M, Gupta A, De Melo WC, Huang YY, Yin R, Chandran R, Kumar R, Otufowora A, Nyame T, Hamblin MR. Animal models of skin disease for drug discovery. Expert Opin Drug Discov 2013; 8:331-55. PubMed
  • Huang YY, Vecchio D, Avci P, Yin R, Garcia-Diaz M, Hamblin MR. Melanoma resistance to photodynamic therapy: new insights. Biol Chem 2013. PubMed
  • Sharma SK, Krayer M, Sperandio FF, Huang L, Huang YY, Holten D, Lindsey JS, Hamblin MR. Synthesis and evaluation of cationic bacteriochlorin amphiphiles with effective in vitro photodynamic activity against cancer cells at low nanomolar concentration. J Porphyr Phthalocyanines 2013; 17:73-85. PubMed
  • Kato IT, Prates RA, Sabino CP, Fuchs BB, Tegos GP, Mylonakis E, Hamblin MR, Ribeiro MS. Antimicrobial photodynamic inactivation inhibits Candida albicans virulence factors and reduces in vivo pathogenicity. Antimicrob Agents Chemother 2012. PubMed
  • Xuan W, Vatansever F, Huang L, Wu Q, Xuan Y, Dai T, Ando T, Xu T, Huang YY, Hamblin MR. Transcranial low-level laser therapy improves neurological performance in traumatic brain injury in mice: effect of treatment repetition regimen. PLoS ONE 2013; 8:e53454. PubMed
  • Kourtesi C, Ball AR, Huang YY, Jachak SM, Vera DM, Khondkar P, Gibbons S, Hamblin MR, Tegos GP. Microbial efflux systems and inhibitors: approaches to drug discovery and the challenge of clinical implementation. Open Microbiol J 2013; 7:34-52. PubMed
  • Prates RA, Fuchs BB, Mizuno K, Naqvi Q, Kato IT, Ribeiro MS, Mylonakis E, Tegos GP, Hamblin MR. Effect of virulence factors on the photodynamic inactivation of Cryptococcus neoformans. PLoS ONE 2013; 8:e54387. PubMed
  • Chibebe Junior J, Fuchs BB, Sabino CP, Junqueira JC, Jorge AO, Ribeiro MS, Gilmore MS, Rice LB, Tegos GP, Hamblin MR, Mylonakis E. Photodynamic and antibiotic therapy impair the pathogenesis of Enterococcus faecium in a whole animal insect model. PLoS ONE 2013; 8:e55926. PubMed
  • Huang YY, Balasubramanian T, Yang E, Luo D, Diers JR, Bocian DF, Lindsey JS, Holten D, Hamblin MR. Stable synthetic bacteriochlorins for photodynamic therapy: role of dicyano peripheral groups, central metal substitution (2H, Zn, Pd), and Cremophor EL delivery. ChemMedChem 2012. PubMed
  • Huang L, St Denis TG, Xuan Y, Huang YY, Tanaka M, Zadlo A, Sarna T, Hamblin MR. Paradoxical potentiation of methylene blue-mediated antimicrobial photodynamic inactivation by sodium azide: role of ambient oxygen and azide radicals. Free Radic Biol Med 2012; 53:2062-71. PubMed
  • Yang E, Diers JR, Huang YY, Hamblin MR, Lindsey JS, Bocian DF, Holten D. Molecular electronic tuning of photosensitizers to enhance photodynamic therapy: synthetic dicyanobacteriochlorins as a case study. Photochem Photobiol 2013. PubMed
  • Assis L, Moretti AI, Abrahão TB, Cury V, Souza HP, Hamblin MR, Parizotto NA. Low-level laser therapy (808 nm) reduces inflammatory response and oxidative stress in rat tibialis anterior muscle after cryolesion. Lasers Surg Med 2012; 44:726-35. PubMed
  • Ferraresi C, Hamblin MR, Parizotto NA. Low-level laser (light) therapy (LLLT) on muscle tissue: performance, fatigue and repair benefited by the power of light. Photonics Lasers Med 2013; 1:267-286. PubMed
  • Vatansever F, Hamblin MR. Far infrared radiation (FIR): its biological effects and medical applications. Photonics Lasers Med 2013; 4:255-266. PubMed
  • Vatansever F, Chandran R, Sadasivam M, Chiang LY, Hamblin MR. Multi-Functionality in Theranostic Nanoparticles: is more Always Better? 2013. PubMed
  • St Denis TG, Dai T, Hamblin MR. Killing bacterial spores with blue light: when innate resistance meets the power of light. Photochem Photobiol 2013. PubMed
  • Sharma SK, Mroz P, Dai T, Huang YY, St Denis TG, Hamblin MR. Photodynamic Therapy for Cancer and for Infections: What Is the Difference? Isr. J. Chem. 2012; 52:691-705. PubMed
  • Gupta A, Avci P, Sadasivam M, Chandran R, Parizotto N, Vecchio D, de Melo WC, Dai T, Chiang LY, Hamblin MR. Shining light on nanotechnology to help repair and regeneration. Biotechnol Adv 2013. PubMed
  • Kawakubo M, Eguchi K, Arai T, Kobayashi K, Hamblin MR. Surface layer-preserving photodynamic therapy (SPPDT) in a subcutaneous mouse model of lung cancer. Lasers Surg Med 2012; 44:500-7. PubMed
  • Mroz P, Hamblin MR. The immunosuppressive side of PDT. Photochem Photobiol Sci 2011. PubMed
  • Mroz P, Huang YY, Szokalska A, Zhiyentayev T, Janjua S, Nifli AP, Sherwood ME, Ruzié C, Borbas KE, Fan D, Krayer M, Balasubramanian T, Yang E, Kee HL, Kirmaier C, Diers JR, Bocian DF, Holten D, Lindsey JS, Hamblin MR. Stable synthetic bacteriochlorins overcome the resistance of melanoma to photodynamic therapy. FASEB J 2010; 24:3160-70. PubMed
  • Hamblin MR. Introduction to experimental and clinical studies using low-level laser (light) therapy (LLLT). Lasers Surg Med 2010; 42:447-9. PubMed
  • Chen Z, Zhou S, Chen J, Deng Y, Luo Z, Chen H, Hamblin MR, Huang M. Pentalysine beta-carbonylphthalocyanine zinc: an effective tumor-targeting photosensitizer for photodynamic therapy. ChemMedChem 2010; 5:890-8. PubMed
  • Huang YY, Mroz P, Zhiyentayev T, Sharma SK, Balasubramanian T, Ruzié C, Krayer M, Fan D, Borbas KE, Yang E, Kee HL, Kirmaier C, Diers JR, Bocian DF, Holten D, Lindsey JS, Hamblin MR. In vitro photodynamic therapy and quantitative structure-activity relationship studies with stable synthetic near-infrared-absorbing bacteriochlorin photosensitizers. J Med Chem 2010; 53:4018-27. PubMed
  • Mroz P, Szokalska A, Wu MX, Hamblin MR. Photodynamic therapy of tumors can lead to development of systemic antigen-specific immune response. PLoS ONE 2010; 5:e15194. PubMed
  • Mroz P,Bhaumik J,Dogutan DK,Aly Z,Kamal Z,Khalid L,Kee HL,Bocian DF,Holten D,Lindsey JS,Hamblin MR. Imidazole metalloporphyrins as photosensitizers for photodynamic therapy: Role of molecular charge, central metal and hydroxyl radical production. Cancer Lett 2009; 282:63-76. PubMed
  • Castano AP, Mroz P, Wu MX, Hamblin MR. Photodynamic therapy plus low-dose cyclophosphamide generates antitumor immunity in a mouse model. Proc Natl Acad Sci U S A 2008; 105:5495-500. PubMed
  • Garcez AS, Nuñez SC, Hamblin MR, Ribeiro MS. Antimicrobial effects of photodynamic therapy on patients with necrotic pulps and periapical lesion. J Endod 2008; 34:138-42. PubMed
  • Tawakol A, Castano AP, Gad F, Zahra T, Bashian G, Migrino RQ, Ahmadi A, Stern J, Anatelli F, Chirico S, Shirazi A, Syed S, Fischman AJ, Muller JE, Hamblin MR. Intravascular detection of inflamed atherosclerotic plaques using a fluorescent photosensitizer targeted to the scavenger receptor. Photochem Photobiol Sci 2008; 7:33-9. PubMed
  • Mroz P, Tegos GP, Gali H, Wharton T, Sarna T, Hamblin MR. Photodynamic therapy with fullerenes. Photochem Photobiol Sci 2007; 6:1139-49. PubMed
  • Demidova-Rice TN, Salomatina EV, Yaroslavsky AN, Herman IM, Hamblin MR. Low-level light stimulates excisional wound healing in mice. Lasers Surg Med 2007; 39:706-15. PubMed
  • Mroz P, Pawlak A, Satti M, Lee H, Wharton T, Gali H, Sarna T, Hamblin MR. Functionalized fullerenes mediate photodynamic killing of cancer cells: Type I versus Type II photochemical mechanism. Free Radic Biol Med 2007; 43:711-9. PubMed
  • Fuchs BB, Tegos GP, Hamblin MR, Mylonakis E. Susceptibility of Cryptococcus neoformans to photodynamic inactivation is associated with cell wall integrity. Antimicrob Agents Chemother 2007; 51:2929-36. PubMed
  • Castano AP, Dai T, Yaroslavsky I, Cohen R, Apruzzese WA, Smotrich MH, Hamblin MR. Low-level laser therapy for zymosan-induced arthritis in rats: Importance of illumination time. Lasers Surg Med 2007; 39:543-50. PubMed
  • Møller-Kristensen M, Hamblin MR, Thiel S, Jensenius JC, Takahashi K. Burn injury reveals altered phenotype in mannan-binding lectin-deficient mice. J Invest Dermatol 2007; 127:1524-31. PubMed
  • Tang HM, Hamblin MR, Yow CM. A comparative in vitro photoinactivation study of clinical isolates of multidrug-resistant pathogens. J Infect Chemother 2007; 13:87-91. PubMed
  • Garcez AS, Nunez SC, Lage-Marques JL, Hamblin MR, Ribeiro MS. Photonic real-time monitoring of bacterial reduction in root canals by genetically engineered bacteria after chemomechanical endodontic therapy. Braz Dent J 2008; 18:202-7. PubMed
  • Garcez AS, Ribeiro MS, Tegos GP, Núñez SC, Jorge AO, Hamblin MR. Antimicrobial photodynamic therapy combined with conventional endodontic treatment to eliminate root canal biofilm infection. Lasers Surg Med 2006; 39:59-66. PubMed
  • Apidianakis Y, Mindrinos MN, Xiao W, Tegos GP, Papisov MI, Hamblin MR, Davis RW, Tompkins RG, Rahme LG. Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following trauma. PLoS ONE 2007; 2:e1356. PubMed
  • Anatelli F, Mroz P, Liu Q, Yang C, Castano AP, Swietlik E, Hamblin MR. Macrophage-targeted photosensitizer conjugate delivered by intratumoral injection. Mol Pharm 2006; 3:654-64. PubMed
  • Foley JW, Song X, Demidova TN, Jalil F, Jilal F, Hamblin MR. Synthesis and properties of benzo[a]phenoxazinium chalcogen analogues as novel broad-spectrum antimicrobial photosensitizers. J Med Chem 2006; 49:5291-9. PubMed
  • Castano AP, Mroz P, Hamblin MR. Photodynamic therapy and anti-tumour immunity. Nat Rev Cancer 2006; 6:535-45. PubMed
  • Borbas KE, Mroz P, Hamblin MR, Lindsey JS. Bioconjugatable porphyrins bearing a compact swallowtail motif for water solubility. Bioconjug Chem 2006; 17:638-53. PubMed
  • Park J, Mroz P, Hamblin MR, Yaroslavsky AN. Dye-enhanced multimodal confocal microscopy for noninvasive detection of skin cancers in mouse models. J Biomed Opt 2010; 15:026023. PubMed