Photo of Motaz Qadan,  MD, PhD

Motaz Qadan, MD, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 643-5153


mqadan@mgh.harvard.edu

Motaz Qadan, MD, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Surgery, Harvard Medical School
  • Assistant Professor, Surgery, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My research focuses on the tumor microenvironment in the treatment of pancreas cancer. Pancreas cancer is a highly resilient tumor and by influencing the environment and character of the tumor, early data suggests that the disease may be rendered more susceptible to treatments including chemotherapy, radiation, and immunotherapy. I am currently involved in setting up clinical trials related to novel agents in this field.

In addition, I am interested in clinical outcomes research that focuses on methods to collect, analyze, and improve outcomes related to cancer surgery at the National level. I conducts my outcomes research at the Codman Center for Clinical Effectiveness in Surgery. Some of my current interests include optimization of patients who are due to undergo oncologic surgery by improving their nutritional, physical, and psychological well-being prior to operation, as well as a specific focus on surgical intervention in the palliative setting.

Publications

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  • Gromisch C, Qadan M, Albuquerque Machado M, Liu K, Colson Y, Grinstaff MW. Pancreatic Adenocarcinoma: Unconventional Approaches for an Unconventional Disease. Cancer Res 2020. PubMed
  • Rodrigues C, Hank T, Qadan M, Ciprani D, Mino-Kenudson M, Weekes CD, Ryan DP, Clark JW, Allen JN, Hong TS, Wo JY, Ferrone CR, Warshaw AL, Lillemoe KD, Fernandez-Del Castillo C. Impact of adjuvant therapy in patients with invasive intraductal papillary mucinous neoplasms of the pancreas. Pancreatology 2020. PubMed
  • Chawla A, Wo J, Castillo CF, Ferrone CR, Ryan DP, Hong TS, Blaszkowsky LS, Lillemoe KD, Qadan M. Clinical staging in pancreatic adenocarcinoma underestimates extent of disease. Pancreatology 2020. PubMed
  • Molina G, Kasumova GG, Qadan M, Boland GM. Use of immunotherapy and surgery for stage IV melanoma. Cancer 2020. PubMed
  • Qadan M, Kothary N, Sangro B, Palta M. The Treatment of Hepatocellular Carcinoma With Portal Vein Tumor Thrombosis. Am Soc Clin Oncol Educ Book 2020; 40:1-8. PubMed
  • Sell NM, Shafique N, Lee H, Lee GC, Tanabe KK, Ferrone CR, Blaszkowsky LS, Hong TS, Wo J, Qadan M. Socioeconomic determinants of the surgical treatment of colorectal liver metastases. Am J Surg 2020. PubMed
  • Neyaz A, Tabb E, Shih A, Zhao G, Shroff S, Taylor M, Rickelt S, Wo J, Fernandez C, Qadan M, Hong T, Lillemoe KD, Ting D, Ferrone C, Deshpande V. Pancreatic ductal adenocarcinoma: tumor regression grading following neoadjuvant FOLFIRINOX and Radiation. Histopathology 2020. PubMed
  • Zhang ML, Kem M, Rodrigues C, Sandini M, Ciprani D, Hank T, Kunitoki K, Qadan M, Ferrone C, Lillemoe K, Fernández-Del Castillo C, Mino-Kenudson M. Microscopic Size Measurements Predict Outcomes in Post-Neoadjuvant Resections of Pancreatic Ductal Adenocarcinoma (PDAC). Histopathology 2020. PubMed
  • Bitterman DS, Edgington SK, Kilcoyne A, Kim DW, Eyler CE, Qadan M, Ferrone CR, Tanabe KK, Goyal L, Zhu AX, Wo JY, Hong TS. Palliative External Beam Radiation Therapy for Hepatocellular Carcinoma With Right Atrial Tumor Thrombus. 2020. PubMed
  • Smart AC, Goyal L, Horick N, Petkovska N, Zhu AX, Ferrone CR, Tanabe KK, Allen JN, Drapek LC, Qadan M, Murphy JE, Eyler CE, Ryan DP, Hong TS, Wo JY. Hypofractionated Radiation Therapy for Unresectable/Locally Recurrent Intrahepatic Cholangiocarcinoma. Ann Surg Oncol 2019. PubMed
  • Lee GC, Bordeianou LG, Francone TD, Blaszkowsky LS, Goldstone RN, Ricciardi R, Kunitake H, Qadan M. Superior pathologic and clinical outcomes after minimally invasive rectal cancer resection, compared to open resection. Surg Endosc 2019. PubMed
  • Ferrone C, Goyal L, Qadan M, Gervais D, Sahani DV, Zhu AX, Hong TS, Blaszkowsky LS, Tanabe KK, Vangel M, Amorim BJ, Wo JY, Mahmood U, Pandharipande PV, Catana C, Duenas VP, Collazo YQ, Canamaque LG, Domachevsky L, Bernstine HH, Groshar D, Shih TT, Li Y, Herrmann K, Umutlu L, Rosen BR, Catalano OA. Management implications of fluorodeoxyglucose positron emission tomography/magnetic resonance in untreated intrahepatic cholangiocarcinoma. Eur J Nucl Med Mol Imaging 2019. PubMed
  • Pulvirenti A, Margonis GA, Morales-Oyarvide V, McIntyre CA, Lawrence SA, Goldman DA, Gonen M, Weiss MJ, Ferrone CR, He J, Brennan MF, Cameron JL, Lillemoe KD, Kingham TP, Balachandran V, Qadan M, D'Angelica MI, Jarnagin WR, Wolfgang CL, Castillo CF, Allen PJ. Intraductal Papillary Mucinous Neoplasms: Have IAP Consensus Guidelines Changed our Approach?: Results from a Multi-institutional Study. Ann Surg 2019. PubMed
  • Zhang B, Lee GC, Qadan M, Fong ZV, Mino-Kenudson M, Desphande V, Malleo G, Maggino L, Marchegiani G, Salvia R, Scarpa A, Luchini C, De Gregorio L, Ferrone CR, Warshaw AL, Lillemoe KD, Bassi C, Castillo CF. Revision of Pancreatic Neck Margins Based on Intraoperative Frozen Section Analysis Is Associated With Improved Survival in Patients Undergoing Pancreatectomy for Ductal Adenocarcinoma. Ann Surg 2019. PubMed
  • Harrison JM, Wo JY, Ferrone CR, Horick NK, Keane FK, Qadan M, Lillemoe KD, Hong TS, Clark JW, Blaszkowsky LS, Allen JN, Castillo CF. Intraoperative Radiation Therapy (IORT) for Borderline Resectable and Locally Advanced Pancreatic Ductal Adenocarcinoma (BR/LA PDAC) in the Era of Modern Neoadjuvant Treatment: Short-Term and Long-Term Outcomes. Ann Surg Oncol 2019. PubMed
  • Sandini M, Negreros-Osuna AA, Qadan M, Hank T, Patino M, Ferrone CR, Warshaw AL, Lillemoe KD, Sahani D, Castillo CF. Main Pancreatic Duct to Parenchymal Thickness Ratio at Preoperative Imaging is Associated with Overall Survival in Upfront Resected Pancreatic Cancer. Ann Surg Oncol 2019. PubMed
  • Cauley CE, El-Jawahri AR, Jacobsen JC, Udelsman BV, Jackson VA, Temel JS, Qadan M. DNR, DNI, and DNO? J Palliat Med 2019. PubMed
  • Qadan M, Fernandez-Del Castillo C. Can Prognosis Be Modified in Pancreatic Cancer? Ann Surg Oncol 2019. PubMed
  • Hank T, Sandini M, Qadan M, Weniger M, Ciprani D, Li A, Ferrone CR, Warshaw AL, Lillemoe KD, Fernández-Del Castillo C. Diabetes mellitus is associated with unfavorable pathologic features, increased postoperative mortality, and worse long-term survival in resected pancreatic cancer. Pancreatology 2019. PubMed
  • Amorim BJ, Hong TS, Blaszkowsky LS, Ferrone CR, Berger DL, Bordeianou LG, Ricciardi R, Clark JW, Ryan DP, Wo JY, Qadan M, Vangel M, Umutlu L, Groshar D, Cañamaques LG, Gervais DA, Mahmood U, Rosen BR, Catalano OA. Clinical impact of PET/MR in treated colorectal cancer patients. Eur J Nucl Med Mol Imaging 2019; 46:2260-2269. PubMed
  • Udelsman BV, Lilley EJ, Qadan M, Chang DC, Lillemoe KD, Lindvall C, Cooper Z. Deficits in the Palliative Care Process Measures in Patients with Advanced Pancreatic Cancer Undergoing Operative and Invasive Nonoperative Palliative Procedures. Ann Surg Oncol 2019. PubMed
  • Fong ZV, Hashimoto DA, Jin G, Haynes AB, Perez N, Qadan M, Ferrone CR, Fernandez-Del Castillo C, Warshaw AL, Lillemoe KD, Traeger LN, Chang DC. Simulated Volume-Based Regionalization of Complex Procedures: Impact on Spatial Access to Care. Ann Surg 2019. PubMed
  • Hank T, Sandini M, Ferrone CR, Rodrigues C, Weniger M, Qadan M, Warshaw AL, Lillemoe KD, Fernández-Del Castillo C. Association Between Pancreatic Fistula and Long-term Survival in the Era of Neoadjuvant Chemotherapy. JAMA Surg 2019. PubMed
  • Lee GC, Gamblin TC, Fong ZV, Ferrone CR, Goyal L, Lillemoe KD, Blaszkowsky LS, Tanabe KK, Qadan M. Facility Type is Associated with Margin Status and Overall Survival of Patients with Resected Intrahepatic Cholangiocarcinoma. Ann Surg Oncol 2019. PubMed
  • Udelsman B, Lee K, Qadan M, Lillemoe KD, Chang D, Lindvall C, Cooper Z. Management of Pneumoperitoneum: Role and Limits of Nonoperative Treatment. Ann Surg 2019. PubMed
  • Bitterman DS, Sanford NN, Niemierko A, Mahal BA, Qadan M, Ganguli S, Blaszkowsky LS, Zhu AX, Hong TS, Devlin PM, Goyal L, Wo JY. Patterns of Care and Outcomes of Definitive External Beam Radiotherapy and Radioembolization for Localized Hepatocellular Carcinoma: A Propensity Score-adjusted Analysis. Am J Clin Oncol 2019; 42:564-572. PubMed
  • Murphy JE, Wo JY, Ryan DP, Clark JW, Jiang W, Yeap BY, Drapek LC, Ly L, Baglini CV, Blaszkowsky LS, Ferrone CR, Parikh AR, Weekes CD, Nipp RD, Kwak EL, Allen JN, Corcoran RB, Ting DT, Faris JE, Zhu AX, Goyal L, Berger DL, Qadan M, Lillemoe KD, Talele N, Jain RK, DeLaney TF, Duda DG, Boucher Y, Fernández-Del Castillo C, Hong TS. Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer: A Phase 2 Clinical Trial. JAMA Oncol 2019. PubMed
  • Goyal L, Qadan M, Zhu AX. Another Treatment Option for Advanced Hepatocellular Carcinoma With Portal Vein Thrombosis in China. JAMA Oncol 2019. PubMed
  • Lee GC, Ferrone CR, Tanabe KK, Lillemoe KD, Blaszkowsky LS, Zhu AX, Hong TS, Qadan M. Predictors of adjuvant treatment and survival in patients with intrahepatic cholangiocarcinoma who undergo resection. Am J Surg 2019. PubMed
  • Ven Fong Z, Chang DC, Lillemoe KD, Nipp RD, Tanabe KK, Qadan M. Contemporary Opportunity for Prehabilitation as Part of an Enhanced Recovery after Surgery Pathway in Colorectal Surgery. Clin Colon Rectal Surg 2019; 32:95-101. PubMed
  • Sanford NN, Pursley J, Noe B, Yeap BY, Goyal L, Clark JW, Allen JN, Blaszkowsky LS, Ryan DP, Ferrone CR, Tanabe KK, Qadan M, Crane CH, Koay EJ, Eyler C, DeLaney TF, Zhu AX, Wo JY, Grassberger C, Hong TS. Protons versus Photons for Unresectable Hepatocellular Carcinoma: Liver Decompensation and Overall Survival. Int J Radiat Oncol Biol Phys 2019. PubMed
  • Honselmann KC, Pergolini I, Castillo CF, Deshpande V, Ting D, Taylor MS, Bolm L, Qadan M, Wellner U, Sandini M, Bausch D, Warshaw AL, Lillemoe KD, Keck T, Ferrone CR. Timing But Not Patterns of Recurrence Is Different Between Node-negative and Node-positive Resected Pancreatic Cancer. Ann Surg 2019. PubMed
  • Lee GC, Ferrone CR, Vagefi PA, Uppot RN, Tanabe KK, Lillemoe KD, Blaszkowsky LS, Qadan M. Surgical resection versus ablation for early-stage hepatocellular carcinoma: A retrospective cohort analysis. Am J Surg 2019. PubMed
  • Sandini M, Ruscic KJ, Ferrone CR, Warshaw AL, Qadan M, Eikermann M, Lillemoe KD, Fernández-Del Castillo C. Intraoperative Dexamethasone Decreases Infectious Complications After Pancreaticoduodenectomy and is Associated with Long-Term Survival in Pancreatic Cancer. Ann Surg Oncol 2018. PubMed
  • Michelakos T, Xourafas D, Qadan M, Pieretti-Vanmarcke R, Cai L, Patel MS, Adler JT, Fontan F, Basit U, Vagefi PA, Elias N, Tanabe KK, Berger D, Yeh H, Markmann JF, Chang DC, Ferrone CR. Hepatocellular Carcinoma in Transplantable Child-Pugh A Cirrhotics: Should Cost Affect Resection vs Transplantation? J Gastrointest Surg 2018. PubMed
  • Sell NM, Fong ZV, Del Castillo CF, Qadan M, Warshaw AL, Chang D, Lillemoe KD, Ferrone CR. Staging Laparoscopy Not Only Saves Patients an Incision, But May Also Help Them Live Longer. Ann Surg Oncol 2018; 25:1009-1016. PubMed
  • Wu J, Goyal L, Nipp R, Wo J, Qadan M, Uppot RN. The Tipping Point: Key Oncologic Imaging Findings Resulting in Critical Changes in the Management of Malignant Tumors of the Gastrointestinal Tract. 2018. PubMed
  • Michelakos T, Pergolini I, Castillo CF, Honselmann KC, Cai L, Deshpande V, Wo JY, Ryan DP, Allen JN, Blaszkowsky LS, Clark JW, Murphy JE, Nipp RD, Parikh A, Qadan M, Warshaw AL, Hong TS, Lillemoe KD, Ferrone CR. Predictors of Resectability and Survival in Patients with Borderline and Locally Advanced Pancreatic Cancer who Underwent Neoadjuvant Treatment with FOLFIRINOX. Ann Surg 2017. PubMed
  • Miller CL, Taylor MS, Qadan M, Deshpande V, Worthington S, Smalley R, Collura C, Ryan DP, Allen JN, Blaszkowsky LS, Clark JW, Murphy JE, Parikh AR, Berger D, Tanabe KK, Lillemoe KD, Ferrone CR. Prognostic Significance of Surgical Margin Size After Neoadjuvant FOLFOX and/or FOLFIRI for Colorectal Liver Metastases. J Gastrointest Surg 2017. PubMed
  • Qadan M, Davies AR, Polk HC, Allum WH, Brennan MF. Cancer care in the developed world: A comparison of surgical oncology training programs. Am J Surg 2017. PubMed
  • Qadan M, D'Angelica MI. Extending the Limits of Resection for Colorectal Liver Metastases: Positive Resection Margin and Outcome After Resection of Colorectal Cancer Liver Metastases. J Gastrointest Surg 2016; 21:196-198. PubMed
  • Qadan M, Kingham TP. Technical Aspects of Gallbladder Cancer Surgery. Surg Clin North Am 2016; 96:229-45. PubMed
  • Qadan M, Garden OJ, Corvera CU, Visser BC. Management of Postoperative Hepatic Failure. J Am Coll Surg 2016; 222:195-208. PubMed
  • Qadan M, D'Angelica MI. Complex Surgical Strategies to Improve Resectability in Borderline-Resectable Disease. 2017; 11:369-377. PubMed
  • McAuliffe JC, Qadan M, D'Angelica MI. Hepatic resection, hepatic arterial infusion pump therapy, and genetic biomarkers in the management of hepatic metastases from colorectal cancer. J Gastrointest Oncol 2015; 6:699-708. PubMed
  • Tran TB, Qadan M, Dua MM, Norton JA, Poultsides GA, Visser BC. Prognostic relevance of lymph node ratio and total lymph node count for small bowel adenocarcinoma. Surgery 2015; 158:486-93. PubMed
  • Qadan M, Dua M, Worhunsky D, Triadafilopoulos G, Visser B. More with less: pancreas-preserving total duodenectomy. Dig Dis Sci 2015; 60:1565-8. PubMed
  • Dua MM, Qadan M, Lutchman GA, Park WG, Triadafilopoulos G, Visser BC. Non-MalIg(G4)nant Biliary Obstruction: When the Pill Is Mightier than the Knife. Dig Dis Sci 2015; 60:1178-82. PubMed
  • Worhunsky DJ, Qadan M, Dua MM, Park WG, Poultsides GA, Norton JA, Visser BC. Laparoscopic transgastric necrosectomy for the management of pancreatic necrosis. J Am Coll Surg 2014; 219:735-43. PubMed
  • Qadan M, Ma Y, Visser BC, Kunz PL, Fisher GA, Norton JA, Poultsides GA. Reassessment of the current American Joint Committee on Cancer staging system for pancreatic neuroendocrine tumors. J Am Coll Surg 2014; 218:188-95. PubMed
  • Qadan M, Curet MJ, Wren SM. The evolving application of single-port robotic surgery in general surgery. J Hepatobiliary Pancreat Sci 2013; 21:26-33. PubMed
  • Qadan M, Akca O. Reassessing the role of supplemental oxygen in the prevention of surgical site infection. Ann Surg 2012; 256:902-3. PubMed
  • Billeter AT, Qadan M, Druen D, Gardner SA, The T, Polk HC. Does clinically relevant temperature change miRNA and cytokine expression in whole blood? J. Interferon Cytokine Res. 2012; 32:485-94. PubMed
  • Qadan M, Clarke S, Morrow E, Triadafilopoulos G, Visser B. Sump syndrome as a complication of choledochoduodenostomy. Dig Dis Sci 2012; 57:2011-5. PubMed
  • Qadan M, Visser B, Kim J, Pai R, Triadafilopoulos G. Abdominal mass, anemia, diabetes mellitus, and necrolytic migratory erythema. Dig Dis Sci 2012; 57:1465-8. PubMed
  • Billeter AT, Polk HC, Hohmann SF, Qadan M, Fry DE, Jorden JR, McCafferty MH, Galandiuk S. Mortality after elective colon resection: the search for outcomes that define quality in surgical practice. J Am Coll Surg 2012; 214:436-43; discussion 443-4. PubMed
  • Lamb AD, Qadan M, Roberts S, Timlin H, Vowler SL, Campbell FM, Grigor K, Bartlett JM, McNeill SA. CD4+ and CD8+ T-lymphocyte scores cannot reliably predict progression in patients with benign prostatic hyperplasia. BJU Int 2011; 108:E43-50. PubMed
  • Qadan M, Kastenberg Z, Carvalho B, Sultan P. Crossing the pond: applying to train in the USA. Br J Hosp Med (Lond) 2011; 72:M50-2. PubMed
  • Kirkpatrick AW, Papia G, McCloskey SA, Polk HC, Akca O, Qadan M, . CAGS and ACS evidence based reviews in surgery. 36. Effect of high perioperative oxygen fraction on surgical site infection. Can J Surg 2011; 54:67-9. PubMed
  • Qadan M, Polk HC, Hohmann SF, Fry DE. A reassessment of needs and practice patterns in pharmacologic prophylaxis of venous thromboembolism following elective major surgery. Ann Surg 2011; 253:215-20. PubMed
  • Dickinson A, Qadan M, Weller C, Gardner S, Polk HC. In vitro study of variables relevant to perioperative care of the surgical patient: glucose, osmolarity, and rewarming. J Am Coll Surg 2011; 212:180-6. PubMed
  • Lenz AM, Qadan M, Gardner SA, Cheadle WG. Impact of microbial tolerance in persistent secondary Klebsiella pneumoniae peritonitis. Cytokine 2010; 53:84-93. PubMed
  • Brown RE, Qadan M, Martin RC, Polk HC. The evolving importance of readmission data to the practicing surgeon. J Am Coll Surg 2010; 211:558-60. PubMed
  • Qadan M, Battista C, Gardner SA, Anderson G, Akca O, Polk HC. Oxygen and surgical site infection: a study of underlying immunologic mechanisms. Anesthesiology 2010; 113:369-77. PubMed
  • Watkins JM, Qadan M, Battista C, Polk HC. A closer look at surgical quality measures across different surgical specialties. Am J Surg 2010; 200:90-6. PubMed
  • Cronen P, Qadan M, Hicks NZ, Polk HC. Standards of surgery beyond metropolitan centers: a fresh look at perioperative quality measures in small-town America. Am J Surg 2010; 200:97-104. PubMed
  • Kanaan Z, Qadan M, Eichenberger MR, Galandiuk S. The actin-cytoskeleton pathway and its potential role in inflammatory bowel disease-associated human colorectal cancer. Genet Test Mol Biomarkers 2010; 14:347-53. PubMed
  • Qadan M, Weller EB, Gardner SA, Maldonado C, Fry DE, Polk HC. Glucose and surgical sepsis: a study of underlying immunologic mechanisms. J Am Coll Surg 2010; 210:966-74. PubMed
  • Dickinson A, Qadan M, Polk HC. Optimizing surgical care: a contemporary assessment of temperature, oxygen, and glucose. Am Surg 2010; 76:571-7. PubMed
  • Qadan M, Cheadle WG. Controversies in host defense against surgical site infection. Expert Rev Anti Infect Ther 2009; 7:1043-7. PubMed
  • Polk HC, Vitale DS, Qadan M. The very busy urban surgeon: another face of the evermore obvious shortage of general surgeons. J Am Coll Surg 2009; 209:144-7. PubMed
  • Qadan M, Gardner SA, Vitale DS, Lominadze D, Joshua IG, Polk HC. Hypothermia and surgery: immunologic mechanisms for current practice. Ann Surg 2009; 250:134-40. PubMed
  • Qadan M, Akça O, Mahid SS, Hornung CA, Polk HC. Perioperative supplemental oxygen therapy and surgical site infection: a meta-analysis of randomized controlled trials. Arch Surg 2009; 144:359-66; discussion 366-7. PubMed
  • Qadan M, Cheadle WG. Common microbial pathogens in surgical practice. Surg Clin North Am 2009; 89:295-310, vii. PubMed
  • Qadan M, Tyson M, McCafferty MH, Hohmann SF, Polk HC. Venous thromboembolism in elective operations: balancing the choices. Surgery 2008; 144:654-60, discussion 660-1. PubMed
  • Lamb AD, Qadan M, Gray AJ. Detection of occult pneumothoraces in the significantly injured adult with blunt trauma. Eur J Emerg Med 2007; 14:65-7. PubMed
  • Chia S, Qadan M, Newton R, Ludlam CA, Fox KA, Newby DE. Intra-arterial tumor necrosis factor-alpha impairs endothelium-dependent vasodilatation and stimulates local tissue plasminogen activator release in humans. Arterioscler Thromb Vasc Biol 2003; 23:695-701. PubMed
  • Ahdoot M, Qadan M, Santa-Maria M, Kennedy WA, Ilano A. Indirect inguinal hernia with uterine tissue in a male: A case of persistent Mullerian duct syndrome and literature review. Can Urol Assoc J 2013; 7:E121-4. PubMed
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