Photo of Naoko Sasamoto,  MD, PhD

Naoko Sasamoto, MD, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 732-7066


nsasamoto@bwh.harvard.edu

Naoko Sasamoto, MD, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Instructor, Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School
  • Instructor, Department of Obstetrics and Gynecology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

I am a gynecologist and clinical oncologist with research focus on improving ovarian cancer outcomes by applying molecular epidemiology to elucidate ovarian cancer etiology and improve clinical management through personalized clinical care. My epidemiologic research training focused on evaluating blood and tissue-based biomarkers in population-based studies. Thus far, I have conducted research on improving CA125 as ovarian cancer screening biomarker using predictive modeling as well as identifying novel modifiable risk factors to prevent ovarian cancer. Building on my clinical expertise and research training in epidemiology, I am committed to a career in ovarian cancer research by utilizing multi-omics data in translational and population-health science research to further our understanding of disease etiology and identify novel personalized strategies for prevention, early detection, and treatment that will improve ovarian cancer survival.

Publications from Harvard Catalyst Profiles

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  • Kang EY, Millstein J, Popovic G, Meagher NS, Bolithon A, Talhouk A, Chiu DS, Anglesio MS, Leung B, Tang K, Lambie N, Pavanello M, Da-Anoy A, Lambrechts D, Loverix L, Olbrecht S, Bisinotto C, Garcia-Donas J, Ruiz-Llorente S, Yagüe-Fernandez M, Edwards RP, Elishaev E, Olawaiye A, Taylor S, Ataseven B, du Bois A, Harter P, Lester J, Høgdall CK, Armasu SM, Huang Y, Vierkant RA, Wang C, Winham SJ, Heublein S, Kommoss FKF, Cramer DW, Sasamoto N, van-Wagensveld L, Lycke M, Mateoiu C, Joseph J, Pike MC, Odunsi K, Tseng CC, Pearce CL, Bilic S, Conrads TP, Hartmann A, Hein A, Jones ME, Leung Y, Beckmann MW, Ruebner M, Schoemaker MJ, Terry KL, El-Bahrawy MA, Coulson P, Etter JL, LaVigne-Mager K, Andress J, Grube M, Fischer A, Neudeck N, Robertson G, Farrell R, Barlow E, Quinn C, Hettiaratchi A, Casablanca Y, Erber R, Stewart CJR, Tan A, Yu Y, Boros J, Brand AH, Harnett PR, Kennedy CJ, Nevins N, Morgan T, Fasching PA, Vergote I, Swerdlow AJ, Candido Dos Reis FJ, Maxwell GL, Neuhausen SL, Barquin-Garcia A, Modugno F, Moysich KB, Crowe PJ, Hirasawa A, Heitz F, Karlan BY, Goode EL, Sinn P, Horlings HM, Høgdall E, Sundfeldt K, Kommoss S, Staebler A, Wu AH, Cohen PA, DeFazio A, Lee CH, Steed H, Le ND, Gayther SA, Lawrenson K, Pharoah PDP, Konecny G, Cook LS, Ramus SJ, Kelemen LE, Köbel M. MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma. Virchows Arch 2021. PubMed
  • Sasamoto N, Babic A, Vitonis AF, Titus L, Cramer DW, Trabert B, Tworoger SS, Terry KL. Common Analgesic Use for Menstrual Pain and Ovarian Cancer Risk. Cancer Prev Res (Phila Pa) 2021; 14:795-802. PubMed
  • Sasamoto N, Wang T, Townsend MK, Hecht JL, Eliassen AH, Song M, Terry KL, Tworoger SS, Harris HR. Prospective Analyses of Lifestyle Factors Related to Energy Balance and Ovarian Cancer Risk by Infiltration of Tumor-Associated Macrophages. Cancer Epidemiol Biomarkers Prev 2021; 30:920-926. PubMed
  • Sasamoto N, Vitonis AF, Fichorova RN, Yamamoto HS, Terry KL, Cramer DW. Racial/ethnic differences in average CA125 and CA15.3 values and its correlates among postmenopausal women in the USA. Cancer Causes Control 2021; 32:299-309. PubMed
  • Yang J, Sasamoto N, Babic A, Vitonis AF, Townsend MK, Titus L, Cramer DW, Tworoger SS, Terry KL. Intrauterine device use and risk of ovarian cancer: results from the New England Case-Control study and Nurses' Health Studies. Int. J. Cancer 2021. PubMed
  • Biswas S, Mandal G, Payne KK, Anadon CM, Gatenbee CD, Chaurio RA, Costich TL, Moran C, Harro CM, Rigolizzo KE, Mine JA, Trillo-Tinoco J, Sasamoto N, Terry KL, Marchion D, Buras A, Wenham RM, Yu X, Townsend MK, Tworoger SS, Rodriguez PC, Anderson AR, Conejo-Garcia JR. IgA transcytosis and antigen recognition govern ovarian cancer immunity. Nature 2021. PubMed
  • Cramer DW, Vitonis AF, Sasamoto N, Yamamoto H, Fichorova RN. Epidemiologic and biologic correlates of serum HE4 and CA125 in women from the National Health and Nutritional Survey (NHANES). Gynecol Oncol 2021. PubMed
  • Sasamoto N, Farland LV, Vitonis AF, Harris HR, DiVasta AD, Laufer MR, Terry KL, Missmer SA. In utero and early life exposures in relation to endometriosis in adolescents and young adults. Eur J Obstet Gynecol Reprod Biol 2020; 252:393-398. PubMed
  • Sasamoto N, Yland J, Vitonis AF, Cramer DW, Titus LJ, De Vivo I, Missmer SA, Terry KL. Peripheral Blood Leukocyte Telomere Length and Endometriosis. Reprod Sci 2020. PubMed
  • Babic A, Sasamoto N, Rosner BA, Tworoger SS, Jordan SJ, Risch HA, Harris HR, Rossing MA, Doherty JA, Fortner RT, Chang-Claude J, Goodman MT, Thompson PJ, Moysich KB, Ness RB, Kjaer SK, Jensen A, Schildkraut JM, Titus LJ, Cramer DW, Bandera EV, Qin B, Sieh W, McGuire V, Sutphen R, Pearce CL, Wu AH, Pike M, Webb PM, Modugno F, Terry KL. Association Between Breastfeeding and Ovarian Cancer Risk. JAMA Oncol 2020. PubMed
  • Sasamoto N, DePari M, Vitonis AF, Laufer MR, Missmer SA, Shafrir AL, Terry KL. Evaluation of CA125 in relation to pain symptoms among adolescents and young adult women with and without surgically-confirmed endometriosis. PLoS ONE 2020; 15:e0238043. PubMed
  • Sasamoto N, Babic A, Rosner BA, Fortner RT, Vitonis AF, Yamamoto H, Fichorova RN, Titus LJ, Tjønneland A, Hansen L, Kvaskoff M, Fournier A, Mancini FR, Boeing H, Trichopoulou A, Peppa E, Karakatsani A, Palli D, Grioni S, Mattiello A, Tumino R, Fiano V, Onland-Moret NC, Weiderpass E, Gram IT, Quirós JR, Lujan-Barroso L, Sánchez MJ, Colorado-Yohar S, Barricarte A, Amiano P, Idahl A, Lundin E, Sartor H, Khaw KT, Key TJ, Muller D, Riboli E, Gunter M, Dossus L, Trabert B, Wentzensen N, Kaaks R, Cramer DW, Tworoger SS, Terry KL. Development and validation of circulating CA125 prediction models in postmenopausal women. 2019; 12:116. PubMed
  • Sasamoto Y, Sasamoto N, Tran J, Mishra A, Ksander BR, Frank MH, Frank NY. Investigation of factors associated with ABCB5-positive limbal stem cell isolation yields from human donors. Ocul Surf 2019. PubMed
  • Farland LV, Prescott J, Sasamoto N, Tobias DK, Gaskins AJ, Stuart JJ, Carusi DA, Chavarro JE, Horne AW, Rich-Edwards JW, Missmer SA. Endometriosis and Risk of Adverse Pregnancy Outcomes. Obstet Gynecol 2019; 134:527-536. PubMed
  • Sasamoto N, Babic A, Rosner BA, Fortner RT, Vitonis AF, Yamamoto HS, Fichorova RN, Tjonneland A, Hansen L, Overvad K, Kvaskoff M, Fournier A, Romana Mancini F, Boeing H, Trichopoulou A, Peppa E, Karakatsani A, Palli D, Pala V, Mattiello A, Tumino R, Grasso CC, Onland-Moret NC, Weiderpass E, Quirós JR, Lujan-Barroso L, Rodríguez-Barranco M, Colorado-Yohar S, Barricarte A, Dorronsoro M, Idahl A, Lundin EA, Sartor H, Khaw KT, Key TJ, Muller DC, Riboli E, Gunter MJ, Dossus L, Kaaks R, Cramer DW, Tworoger SS, Terry KL. Predicting circulating CA125 levels among healthy premenopausal women. Cancer Epidemiol Biomarkers Prev 2019. PubMed
  • Tucker DW, Getchell CR, McCarthy ET, Ohman AW, Sasamoto N, Xu S, Ko JY, Gupta M, Shafrir AL, Medina JE, Lee JJ, Macdonald LA, Malik A, Hasselblatt KT, Li W, Zhang H, Kaplan SJ, Murphy G, Hirsch MS, Liu J, Matulonis UA, Terry KL, Lian CG, Dinulescu DM. Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer. Clin Cancer Res 2017. PubMed
  • Adachi K, Takahashi K, Nakamura K, Otake A, Sasamoto N, Miyoshi Y, Shioji M, Yamamoto Y, Fujitani M, Wakimoto A, Tokuhira A, Kobayashi E, Yoshimura A, Sawada K, Kimura T. Postoperative administration of dienogest for suppressing recurrence of disease and relieving pain in subjects with ovarian endometriomas. Gynecol. Endocrinol. 2016; 32:646-649. PubMed
  • Otake A, Sasase A, Suzuki A, Takahashi K, Sasamoto N, Miyoshi Y, Shioji M, Yamamoto Y, Adachi K. Assessment of age-specific safety of laparoscopic surgery in elderly patients with ovarian tumors. J Obstet Gynaecol Res 2016; 42:297-301. PubMed
  • Sasamoto N, Tomimatsu T, Nagamine K, Oshida M, Kashiwagi H, Koyama S, Kanagawa T, Arahori H, Tomiyama Y, Kimura T. Fetal and neonatal anemia associated with anti-Jr(a) : a case report showing a poorly hemolytic mechanism. J Obstet Gynaecol Res 2011; 37:1132-6. PubMed
  • Amemiya K, Adachi K, Sasamoto N, Yamamoto Y. Transumbilical extraction of 151-300-g myomas without morcellator versus conventional laparoscopic myomectomy with power morcellator. Gynecol Minim Invasive Ther ; 6:162-166. PubMed
  • Sasamoto N, Ueda Y, Amemiya K, Enomoto T, Morii E, Adachi K. Endometrial adenocarcinoma arising in a Turner's syndrome patient with spontaneous menstruation: a case report. J Reprod Med ; 59:177-80. PubMed
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