Dr. Paul Nguyen is an internationally-recognized expert in prostate cancer clinical care and research. He has published over 350 original research articles and has national leadership as the vice-chair of the ARS/ACR Appropriateness Criteria Committee for Prostate Cancer and Chair of the Program Committee for the 2019 ASTRO/SUO/ASCO Genitourinary Cancers Symposium. He is the Principal Investigator of the multi-center randomized FORMULA-509 trial and co-chair of the international randomized ENZARAD trial. He serves as the DF/BWCC Genitourinary Clinical Center Director for Radiation Oncology, Vice-Chair for Clinical Research in the Department of Radiation Oncology, and Professor at Harvard Medical School. He received his AB from Harvard College, MD from Harvard Medical School, and completed his residency at the Harvard Radiation Oncology Program where he served as chief resident.
My clinical and research focus is personalizing treatment for men with prostate cancer and optimizing their outcomes. The major areas of focus include:
1) Using genomics and clinical factors to optimize the use of androgen deprivation therapy (ADT) with radiation: This work includes understanding which patients are most likely vs. least likely to benefit from ADT, understanding the mechanisms by which ADT may be causing harm, and developing ways to minimize those harms.
2) Translational/Genetic Research: Using archived prostate tissue at the DFCI/BWH and colleagues at the Harvard School of Public Health, we are identifying biomarkers for prostate cancer recurrence and molecular pathways that can potentially be targeted to minimize the risk of recurrence.
3) Technical Innovations in the Delivery of Radiation: Working with collaborators in physics, radiology, and outside collaborators in engineering, we seek to reduce the side-effects of prostate brachytherapy by using additional imaging and novel devices to decrease the dose delivered to the urethra and rectum.
4) Health services research in prostate cancer